Inverse Association between Pulmonary Function and C-Reactive Protein in Apparently Healthy Subjects

Aronson, Doron; Roterman, Inon; Yigla, Mordechay; Kerner, Arthur; Avizohar, Ophir; Sella, Ron; Bartha, Peter; Levy, Yishai; Markiewicz, Walter

doi:10.1164/rccm.200602-243oc

Cited by 113 publications

(101 citation statements)

References 40 publications

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“…Cross-sectional associations between poor lung function and CRP have previously been shown in chronic obstructive pulmonary disease patients [22][23][24] and in healthy subjects [2,[13][14][15]25]. Longitudinal studies have also demonstrated that the decline in lung function predicts CRP levels at followup [14,15].…”

Section: Discussionmentioning

confidence: 88%

High-sensitive C-reactive protein is associated with reduced lung function in young adults

Rasmussen¹,

Mikkelsen²,

Hancox³

et al. 2008

European Respiratory Journal

100

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Systemic inflammation has been associated with reduced lung function. However, data on the interrelationships between lung function and inflammation are sparse, and it is not clear if low-grade inflammation leads to reduced lung function.Associations between high-sensitive C-reactive protein (CRP) and spirometric lung function were assessed in a population-based cohort of ,1,000 Danes aged 20 yrs.In males, the average decline in forced expiratory volume in one second (FEV1) in the highest CRP quintile was 23 mL?yr -1 versus 1.6 mL?yr -1 in the lowest quintile. In females, the average decline was 6.2 mL?yr -1 in the highest CRP quintile versus an increase of 1.8 mL?yr -1 in the lowest CRP quintile. In a multiple regression analysis adjusted for sex, body mass index, cardiorespiratory fitness, smoking, asthma, airway hyperresponsiveness and serum eosinophil cationic protein, higher levels of CRP at age 20 yrs were associated with a greater reduction in both FEV1 and forced vital capacity between ages 20 and 29 yrs. The findings show that higher levels of C-reactive protein in young adults are associated with subsequent decline in lung function, suggesting that low-grade systemic inflammation in young adulthood may lead to impaired lung function independently of the effects of smoking, obesity, cardiorespiratory fitness, asthma and eosinophilic inflammation.

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Section: Discussionmentioning

confidence: 88%

High-sensitive C-reactive protein is associated with reduced lung function in young adults

Rasmussen¹,

Mikkelsen²,

Hancox³

et al. 2008

European Respiratory Journal

100

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“…Systemic inflammation is associated with both OLD and CVD, which suggests that an inflammatory environment contributes to the progression of both these diseases. However, a recent study showed that the inverse relationship between systemic inflammation (CRP) and pulmonary function also occurs in apparently healthy subjects, without pulmonary disease and with no smoking history (Aronson et al, 2006). As low lung function is accompanied by lowgrade inflammation even in the preclinical stage of OLD, the prolonged period of lung function decline that occurs with aging means that individuals have long-term exposure to pro-inflammatory mediators, which is likely to contribute to CVD development.…”

Section: Dietary Fat Inflammation and Lung Functionmentioning

confidence: 99%

“…However, lung function also declines in the absence of these exposures, suggesting that other risk factors are important (Buist et al, 2007). Lung function is inversely associated with systemic inflammatory mediators, such as interleukin (IL)-6 (Donaldson et al, 2005) and C-reactive protein (CRP) (Aronson et al, 2006). Thus, systemic inflammation may be an important mechanism contributing to the loss of lung function, and the development of OLD and other chronic diseases, such as cardiovascular disease (CVD).…”

Section: Introductionmentioning

confidence: 99%

Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function

et al. 2010

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Background/objectives: Preservation of lung health with aging is an important health issue in the general population, as loss of lung function with aging can lead to the development of obstructive lung disease and is a predictor of all-cause and cardiovascular mortality. Inflammation is increasingly linked to loss of lung function and evidence suggests that consumption of dietary fat exacerbates inflammation. We aimed to determine the association between dietary fat intake and lung function in older people. Subjects/methods: Participants from the Hunter community study, a population-based cohort, were recruited during 2004 and 2005. Participants received a clinical assessment, including spirometry, and provided a blood sample. Diets were analyzed using food-frequency questionnaires. Plasma interleukin (IL)-6 and C-reactive protein was measured by Enzyme-Linked immunosorbent assay. Results: Using backward stepwise linear regression, %energy from dietary fat, age and plasma IL-6 were considered as negative predictors of forced expiratory volume in one second (FEV 1 ) in men. Also in men, %energy intake from dietary fat, age, body mass index and IL-6 were negative predictors of %predicted forced vital capacity (FVC). Smoking and age were negative predictors of FEV 1 /FVC. In women, plasma IL-6 and age were negative predictors of %FVC, whereas obesity was positively associated with FEV 1 /FVC. Conclusions: An increased proportion of fat in the diet is associated with the reduced lung function in older men. Dietary-fat induced innate immune activation and IL-6 release may contribute to this effect. Dietary interventions involving fat restriction should be further investigated as means of preserving lung function with aging.

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“…While recent studies have shown negative associations for dietary TAC with C-reactive protein (Brighenti et al, 2005;Aronson et al, 2006), gastric cancer (Serafini et al, 2002) and total mortality (Agudo et al, 2007), no study has apparently considered the TAC of the diet in relation to lung function.…”

Section: Introductionmentioning

confidence: 99%

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

et al. 2011

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Background/Objectives: Antioxidant-rich foods may favorably influence lung function. We examined possible associations between the total dietary antioxidant capacity (TAC) and pulmonary function in a healthy Italian population. Subjects/Methods: Until May 2009, 22 300 persons were randomly recruited from the general population in the Moli-sani project. A sample only including healthy women (5824) and men (5848) was analyzed. TAC was measured in foods by three different assays and the ferric reducing-antioxidant power (FRAP) assay was selected as the better indicator of dietary TAC. The European Investigation into Cancer and Nutrition Food Frequency Questionnaire was used for dietary assessment. The association between quintiles of dietary FRAP and pulmonary indexes was assessed using analysis of variance separately for men and women. Results: After adjustment for confounders, women in the highest quintile of FRAP intake had þ 39 ml forced expiratory volume in the first second (FEV 1 ) and þ 54 ml forced vital capacity, compared with those in the lowest quintile (P for trend p0.006). Stratified analysis showed that this relationship only occurred in women who were premenopausal/never smokers. In this subgroup, the observed effect of higher FRAP intake on FEV 1 was equivalent to an improvement in pulmonary age of 3.3 years. In men, all significant associations between pulmonary function and TAC were lost after adjustment for confounding. Conclusions: Dietary TAC may have a favorable role in respiratory health, particularly in premenopausal/never smoker women.

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Inverse Association between Pulmonary Function and C-Reactive Protein in Apparently Healthy Subjects

Abstract: An inverse linear relationship exists between CRP concentrations and measures of pulmonary function in subjects without pulmonary disease and in never-smokers. These results indicate that systemic inflammation may be linked to early perturbations of pulmonary function.

Cited by 113 publications

References 40 publications

High-sensitive C-reactive protein is associated with reduced lung function in young adults

High-sensitive C-reactive protein is associated with reduced lung function in young adults

Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function

Total dietary antioxidant capacity and lung function in an Italian population: a favorable role in premenopausal/never smoker women

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