Inverse Association Between Persistence With Antidepressant Medication and Onset of Chronic Pain in Patients With Depression

Higa, Shingo; Nakamura, Toshio; Ohwaki, Kazuhiro

doi:10.1097/jcp.0000000000001544

Cited by 1 publication

(3 citation statements)

References 47 publications

(91 reference statements)

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Section: Discussionmentioning

confidence: 99%

“…A threshold of 80% is commonly used to ensure good adherence to medication (Karve et al, 2009;Baumgartner et al, 2018;Hartman et al, 2019). As prescriptions are not reusable for a refill in Japan, the MPR can be substituted as an indicator of the prescription continuation rate in real-world clinical Frontiers in Physiology frontiersin.org practice (Kuwabara et al, 2015;Burge et al, 2016;Higa et al, 2022;Komatsu et al, 2022). By using the threshold of MPR 80%, there was a significant difference in the median prescription days of PBs between the MPR<80% and MPR ≥80% groups (655 and 1,309 days, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, we sought to assess the effects of long-term, chronic treatment with a PB on S-K control by dividing patients into two groups based on the medication possession ratio (MPR), using a threshold of 80% as an indicator of long-term and chronic use ( Karve et al, 2009 ; Kuwabara et al, 2015 ; Burge et al, 2016 ; Baumgartner et al, 2018 ; Hartman et al, 2019 ; Higa et al, 2022 ; Komatsu et al, 2022 ). We also assessed the clinical outcomes in patients with HK to understand optimal management in real-world clinical practice.…”

Section: Introductionmentioning

confidence: 99%

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Impact of chronic potassium binder treatment on the clinical outcomes in patients with hyperkalemia: Results of a nationwide hospital-based cohort study

Kanda

Morita²,

Yajima³

2023

Front. Physiol.

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Introduction: Hyperkalemia (HK) is a common disorder in patients with heart failure or chronic kidney disease, and potassium binders (PBs) are recommended to control serum potassium (S-K) levels. Although HK is often a chronic condition, short-term and intermittent PBs treatment has been largely applied to control S-K levels, and little is known about the impact of long-term and chronic PBs treatment on clinical outcomes.Method: This retrospective cohort study was conducted using a Japanese claims database (April 2008–September 2018). HK was defined as at least two S-K ≥5.1 mmol/L within a 12-month(M) interval. The index date was defined as the initial PB prescription date, and the S-K values were examined at 3M, 6M, and 12M after the index. The medication possession ratio (MPR) was used to evaluate the length of the prescribed period of PB, as prescription refill was not allowed in Japan. Clinical outcomes were analyzed by comparing MPR <80% to MPR ≥80% using Cox proportional hazards regression.Results: We found 4,321 patients with HK and were on initial PB treatments, and 993 and 3,328 patients were categorized in the MPR <80% and MPR ≥80% groups, respectively. The mean prescription days ±SD in the MPR <80% and MPR ≥80% groups were 114.7 ± 9.1 and 1151.2 ± 22.5, respectively. S-K value with adjustment by covariates in MPR <80% and MPR ≥80% groups were 5.62 (95% CI: 5.57–5.68) and 5.72 (95% CI: 5.68–5.76) at index followed by 4.65 (95% CI: 4.58–4.71) and 4.57 (95% CI: 4.51–4.62) at 3M, respectively. The hazard ratios of incidence rates in hospitalization was 1.41 (p < 0.001), introduction of renal replacement therapy was 1.25 (p < 0.003), recurrent HK was 1.67 (p < 0.001), and decreased eGFR was 1.41 (p < 0.001), respectively.Conclusion: These results indicate a higher risk of adverse outcomes when PBs were not prescribed chronically, whereas S-K levels were similarly controlled. Chronic control with continued PBs rather than temporary treatment may be associated with the reduction of adverse clinical outcomes in patients with HK.

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