Inverse association between isoflavones and prediabetes risk: evidence from NHANES 2007–2010 and 2017–2018

Background The lipid accumulation product (LAP) and the visceral adiposity index (VAI) are suggested as dependable measures for assessing visceral fat levels. Prediabetes is recognized as a condition that precedes the potential onset of diabetes. The objective of this research is to investigate how VAI and LAP are related to prediabetes among the adult population in the United States. Methods Information from the 2007–2020 National Health and Nutrition Examination Survey (NHANES) was scrutinized in a cross-sectional study. To evaluate the connection between VAI or LAP and the presence of prediabetes, both univariate analysis and multivariate logistic regression were utilized. Threshold effect analysis and fitted smoothing curves were used to delve into the non-linear association between VAI or LAP and prediabetes. Additional analyses were performed on specific subgroups, along with tests to explore potential interactions. Results In general, 12,564 American adults were included. After full adjustment, prediabetes with VAI (OR: 1.128, 95% CI: 1.073–1.185) or LAP (OR: 1.006, 95% CI: 1.004–1.008) showed a positive correlation. Individuals in the 4th VAI quartile group faced a significant 61.9% elevated risk for prediabetes (OR: 1.619, 95% CI: 1.354–1.937) when contrasted to those in the 1st VAI quartile. Participants in the 4th LAP quartile group had a significant 116.4% elevated risk for prediabetes (OR: 2.164, 95% CI: 1.747–2.681) when contrasted to individuals of the 1st LAP quartile. Smooth curve fitting analysis revealed a nonlinear correlation of VAI or LAP and prediabetes, and threshold effect analysis was used to determine an inflection point of 4.090 for VAI and 68.168 for LAP. Conclusions The values of VAI and LAP are positively associated with the prevalence of prediabetes. The VAI and LAP indices may be used as predictors of prediabetes.

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Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

Guo,

Liu,

Liu

et al. 2024

Preprint

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Background Oxidative stress may be relevant in the progression and cardiovascular complications of prediabetes. The oxidative balance score (OBS) is an emerging metric for assessing dietary and lifestyle oxidative stress exposure. The objective of this prospective cohort study from NHANES 1999–2018 was to explore the association of OBS with all-cause and cardiovascular disease (CVD) mortality in people with prediabetes. Methods OBS was composed of 16 dietary components and 4 lifestyle components based on previous research. Prediabetes was diagnosed based on self-reported history or laboratory criteria. Multivariate Cox proportional hazards regression analyses were used to explore these associations and calculate hazard ratios [HR] and 95% confidence intervals [CI]. Results A total of 8256 adult participants with prediabetes were included. Kaplan-Meier survival analysis showed significantly higher all-cause and CVD-related survival in people with prediabetes at higher OBS. After adjusting for all confounders, OBS, dietary OBS, and lifestyle OBS were all inversely associated with all-cause mortality in people with prediabetes (HR and 95% CI 0.959 (0.946,0.973), 0.965 (0.950,0.980), and 0.847 (0.798,0.899), respectively; all p < 0.0001). Higher OBS was associated with significantly lower all-cause mortality (p for trend all < 0.0001). Similar results were observed for CVD mortality. Most associations were linear, whereas the associations of OBS and dietary OBS with CVD mortality were nonlinear. Mediation analyses suggested that several oxidative stress and systemic inflammatory markers mediated these associations. Stratified and sensitivity analyses demonstrated the stability of the findings. Conclusions Adherence to antioxidant dietary and lifestyle patterns assessed by OBS may help prevent excess mortality in population with prediabetes. These effects may be achieved indirectly by influencing oxidative stress and systemic inflammatory markers.

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Inverse association between isoflavones and prediabetes risk: evidence from NHANES 2007–2010 and 2017–2018

Cited by 4 publications

References 48 publications

Perspective: Observational Studies Involving Low-Soy Intake Populations Have Limited Ability for Providing Insight into the Health Effects of Soybean Isoflavones

Perspective: Observational Studies Involving Low-Soy Intake Populations Have Limited Ability for Providing Insight into the Health Effects of Soybean Isoflavones

Association of visceral adiposity index and lipid accumulation products with prediabetes in US adults from NHANES 2007–2020: A cross-sectional study

Association of oxidative balance scores with all-cause and cardiovascular mortality in individuals with prediabetes and the mediating role of oxidative stress and systemic inflammation: Evidence from NHANES 1999-2018

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