Inverse association between 1,5-anhydroglucitol and neonatal diabetic complications

Yefet, Enav; Twafra, Shams; Shwartz, Neta; Hissin, Noura; Hasanein, Jamal; Colodner, Raul; Mirsky, Neetsa; Nachum, Zohar

doi:10.1007/s12020-019-02058-w

Cited by 5 publications

(6 citation statements)

References 28 publications

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“…The study found that the level of 1,5-AG was significantly negatively correlated with diabetic pregnancy complications, especially in large-for-gestational-age (LGA) and neonatal hypoglycemia cases. There is a strong positive correlation between 1,5-AG and preeclampsia at 1 week of gestation, which was also supported by E Yefet ( 95 ). CL Meek et al.…”

Section: Progress Of Clinical Research On 15-ag For Diabetes Complica...supporting

confidence: 65%

The progress of clinical research on the detection of 1,5-anhydroglucitol in diabetes and its complications

Xu,

Pan,

Chen

2024

Front. Endocrinol.

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1,5-Anhydroglucitol (1,5-AG) is sensitive to short-term glucose fluctuations and postprandial hyperglycemia, which has great potential in the clinical application of diabetes as a nontraditional blood glucose monitoring indicator. A large number of studies have found that 1,5-AG can be used to screen for diabetes, manage diabetes, and predict the perils of diabetes complications (diabetic nephropathy, diabetic cardiovascular disease, diabetic retinopathy, diabetic pregnancy complications, diabetic peripheral neuropathy, etc.). Additionally, 1,5-AG and β cells are also associated with each other. As a noninvasive blood glucose monitoring indicator, salivary 1,5-AG has much more benefit for clinical application; however, it cannot be ignored that its detection methods are not perfect. Thus, a considerable stack of research is still needed to establish an accurate and simple enzyme assay for the detection of salivary 1,5-AG. More clinical studies will also be required in the future to confirm the normal reference range of 1,5-AG and its role in diabetes complications to further enhance the blood glucose monitoring system for diabetes.

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Section: Progress Of Clinical Research On 15-ag For Diabetes Complica...supporting

confidence: 65%

The progress of clinical research on the detection of 1,5-anhydroglucitol in diabetes and its complications

Xu,

Pan,

Chen

2024

Front. Endocrinol.

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“…Blood glucose levels are lower in infants of diabetic mothers, and this may be the reason for the high 1,5-anhydrohexitol levels in the CN group of our study, although their glucose levels are not significantly low ( 39 ). 1,5-Anhydrohexitol has been previously reported to have a negative correlation with neonatal complications arising from diabetic mothers ( 40 ). 1,5-Anhydrohexitol is reported to block proinflammatory cytokines like IL-6 and MCP-1 in LPS-induced murine macrophages ( 41 ).…”

Section: Discussionmentioning

confidence: 99%

“…This is because 1,5-anhydro-D-sorbitol, a 1-deoxy form of glucose, is known to be competitively inhibited by glucose in renal reabsorption ( 41 ). Uptake of 1,5-Anhydro-D-sorbitol has been previously reported to revert neonatal complications arising from diabetic mothers ( 42 ). 1,5-Anhydro-D-sorbitol is reported to block the production of pro-inflammatory cytokines like interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) in murine macrophages treated with lipopolysaccharide (LPS) ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

A six molecule nenonatal serum metabolite biosignature has high neonatal sepsis predictability and resolves upon treatment completion

Ahmed,

Behera,

Sarangi

et al. 2024

Preprint

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Sepsis, a life-threatening multi-organ dysfunction by a dysregulated host response, is one of the leading causes of mortality in neonates. Current microbiology-based sepsis diagnosis is time-consuming, and identifying serum metabolite markers may help develop early screening tools and host-directed therapeutics. A set of 131 neonates (age 41.2% female) were classified as culture-positive or negative sepsis cases (CP, CN) and controls (no sepsis: NS and healthy) based on microbial culture and mass spectrometry results. Most of the sepsis cases were due to Acinetobacter baumannii, and serum samples were collected at the time of presentation and at follow-up time points responding to the treatment. Serum samples were grouped as discovery (n=71) and validation (n=60) sets and analyzed using gas chromatography and mass spectrometry (GC-MS). A set of 882 metabolic features was identified, and molecules with a fold change>1.5, VIP score> 1.0, and t-test p-value<0.05 were identified as important molecules. Signatures of myo-inositol with phenylalanine and myo-inositol with 1,5-anhydrohexitol showed a predictive accuracy of 0.84 and 0.79, respectively, to differentiate CP and CN from HC. Interestingly, the longitudinally followed-up CP and CN sepsis patients completing therapeutic intervention showed a comparable abundance of myo-inositol and phenylalanine to the healthy control levels. These deregulated metabolites contributed by the perturbed metabolic pathways in the immune cells or affected multiple organs of sepsis patients. They could be further explored for their potential as diagnostic and therapeutic targets.

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“…During pregnancies affected by diabetes, the mean maternal serum values of 1,5-AG were negatively associated with neonatal birth weight and tended to be lower in infants with hypoglycemia; the magnitude of the difference between hypoglycemic and normoglycemic was greater for gestational diabetes (83). According to another study, maternal serum level of 1,5-AG at birth was significantly and inversely associated with neonatal complications (such as respiratory distress, hypoglycemia, polycythemia, hyperbilirubinemia, and "large for gestational age" condition), resulting useful in the prediction of complications (84).…”

Section: Monosaccharides and Oligosaccharidesmentioning

confidence: 97%

“…According to another study, maternal serum level of 1,5-AG at birth was significantly and inversely associated with neonatal complications (such as respiratory distress, hypoglycemia, polycythemia, hyperbilirubinemia, and “large for gestational age” condition), resulting useful in the prediction of complications ( 84 ).…”

Section: Monosaccharides and Oligosaccharidesmentioning

confidence: 99%

The Human Breast Milk Metabolome in Overweight and Obese Mothers

et al. 2020

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Pre-pregnancy body mass index (BMI) is a major relevance factor, since maternal overweight and obesity can impair the pregnancy outcome and represent risk factors for several neonatal, childhood, and adult conditions, including excessive weight gain, cardiovascular disease, diabetes mellitus, and even behavioral disorders. Currently, breast milk (BM) composition in such category of mothers was not completely defined. In this field, metabolomics represents the ideal technology, able to detect the whole profile of low molecular weight molecules in BM. Limited information is available on human BM metabolites differences in overweight or obese compared to lean mothers. Analyzing all the metabolomics studies published on Medline in English language, this review evaluated the effects that 8 specific types of metabolites found altered by maternal overweight and obesity (nucleotide derivatives, 5-methylthioadenosine, sugar-alcohols, acylcarnitine and amino acids, polyamines, mono-and oligosaccharides, lipids) can exert on the risk of offspring obesity development and other potentially associated health outcomes and complications. However, metabolites variations in samples collected from overweight and obese mothers and the potentially correlated effects highlighted below still need further investigations and should be confirmed in future metabolomics studies on larger samples. Finally, the positive or negative influence of maternal overweight and obesity on the offspring, potentially exerted by breastfeeding, should be analyzed in close correlation with maternal age, genetic and environmental factors, including diet, and taking into account the interactions occurring between BM metabolites and lactobiome. The evaluation of all the factors affecting BM metabolites in overweight and obese mothers can lead to the comprehensive description of such biofluid and the related effects on breastfed subjects, potentially highlighting personalized needs of BM supplementation or short-and long-term prevention strategies to optimize offspring health.

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Inverse association between 1,5-anhydroglucitol and neonatal diabetic complications

Cited by 5 publications

References 28 publications

The progress of clinical research on the detection of 1,5-anhydroglucitol in diabetes and its complications

The progress of clinical research on the detection of 1,5-anhydroglucitol in diabetes and its complications

A six molecule nenonatal serum metabolite biosignature has high neonatal sepsis predictability and resolves upon treatment completion

The Human Breast Milk Metabolome in Overweight and Obese Mothers

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