Inverse amygdala and medial prefrontal cortex responses to surprised faces

Kim, Hackjin; Somerville, Leah H.; Johnstone, Tom; Alexander, Andrew L.; Whalen, Paul J.

doi:10.1097/00001756-200312190-00006

Cited by 327 publications

(338 citation statements)

References 22 publications

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“…Healthy controls, both at rest and in response to a serotonergic probe, show positive correlations between OFC (BA 11,12) and right ventral amygdala, as was predicted from the model of the ventral amygdala as the component of human amygdala most closely associated with frontal lobe emotion modulation (Kim et al, 2003;Somerville et al, 2004;Whalen et al, 1998). This correlational approach is based on the assumption that significant correlations may reveal an important functional relationship between the structures as discussed by Katz et al (1996).…”

Section: Implications Of Group Differences In Fronto-amygdala Correlamentioning

confidence: 88%

“…Significant negative correlations were also identified between the response of the left amygdala and those of the right OFC as well as the anterior cingulate (Hariri et al, 2003). An fMRI study of surprised faces show increased activation of the right ventral amygdala when the subject interpreted the face negatively, whereas a positive interpretation of the face yielded activation of OFC (Kim et al, 2003). A subsequent study by the same group showed activation of lateral OFC in response to negative vs positive sentences, whereas medial OFC was activated in response to positive vs negative sentences , suggesting that subregions of OFC may play different roles in relation to amygdala function.…”

Section: Introduction the Prefrontal-amygdala Circuitmentioning

confidence: 87%

“…Further, they note that whereas expressions of fear appear to activate the BLC and CN (ie ventral and dorsal amygdala), anger may involve the CN to a lesser degree (than the BLC) because less additional information concerning the stimulus is required (Whalen et al, 2001). Furthermore, fMRI studies by this group have shown that specifically the ventral amygdala is in response to emotional stimuli (Kim et al, 2003. The ventral amygdala (basolateral amygdala in rats)-OFC circuit role in associative encoding and aversive odor was also supported in rat studies of amygdala activity in OFC (Saddoris et al, 2005;Schoenbaum et al, 2003).…”

Section: Subregions Of the Amygdala In Emotionmentioning

confidence: 99%

“…This procedure may have omitted the very anterior end of the amygdaloid complex, but it had the advantage of excluding other extraneous structures from our analysis. Following the suggestion of Kim et al (2003) we divided the amygdala into a top and bottom half, based on the vertical distance on the mid-coronal slice and …”

Section: Regions Of Interest Approachmentioning

confidence: 99%

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Amygdala–Prefrontal Disconnection in Borderline Personality Disorder

New

Hazlett

Buchsbaum

et al. 2007

Neuropsychopharmacol

258

160

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Abnormal fronto-amygdala circuitry has been implicated in impulsive aggression, a core symptom of borderline personality disorder (BPD). We examined relative glucose metabolic rate (rGMR) at rest and after m-CPP (meta-chloropiperazine) with 18 fluorodeoxyglucose (FDG) with positron emission tomography (PET) in 26 impulsive aggressive (IED)-BPD patients and 24 controls. Brain edges/amygdala were visually traced on MRI scans co-registered to PET scans; rGMR was obtained for ventral and dorsal regions of the amygdala and Brodmann areas within the prefrontal cortex (PFC). Correlation coefficients were calculated between rGMR for dorsal/ventral amygdala regions and PFC. Additionally, amygdala volumes and rGMR were examined in BPD and controls. Correlations PFC/amygdala Placebo: Controls showed significant positive correlations between right orbitofrontal (OFC) and ventral, but not dorsal, amygdala. Patients showed only weak correlations between amygdala and the anterior PFC, with no distinction between dorsal and ventral amygdala. Correlations PFC/amygdala: m-CPP response: Controls showed positive correlations between OFC and amygdala regions, whereas patients showed positive correlations between dorsolateral PFC and amygdala. Group differences between interregional correlational matrices were highly significant. Amygdala volume/metabolism: No group differences were found for amygdala volume, or metabolism in the placebo condition or in response to meta-chloropiperazine (m-CPP). We demonstrated a tight coupling of metabolic activity between right OFC and ventral amygdala in healthy subjects with dorsoventral differences in amygdala circuitry, not present in IED-BPD. We demonstrated no significant differences in amygdala volumes or metabolism between BPD patients and controls.

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Section: Implications Of Group Differences In Fronto-amygdala Correlamentioning

confidence: 88%

Section: Introduction the Prefrontal-amygdala Circuitmentioning

confidence: 87%

Section: Subregions Of the Amygdala In Emotionmentioning

confidence: 99%

Section: Regions Of Interest Approachmentioning

confidence: 99%

See 2 more Smart Citations

Amygdala–Prefrontal Disconnection in Borderline Personality Disorder

New

Hazlett

Buchsbaum

et al. 2007

Neuropsychopharmacol

258

160

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“…An inverse relationship between mPFC and amygdala activity has often been noted in humans (Kim et al, 2003;Urry et al, 2006). The amygdala plays a prominent role in human anxiety disorders (e.g., Rauch et al, (2006), and heightened amygdala activity in posttraumatic stress disorder (PTSD) during symptomatic states and the processing of traumarelated stimuli has often been reported (e.g., Bremner et al, (1999).…”

Section: Discussionmentioning

confidence: 99%

Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear

et al. 2007

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Fear conditioning and fear extinction play key roles in the development and treatment of anxietyrelated disorders, yet there is little information concerning experiential variables that modulate these processes. Here we examined the impact of exposure to a stressor in a different environment on subsequent fear conditioning and extinction, and whether the degree of behavioral control that the subject has over the stressor is of importance. Rats received a session of either escapable (controllable) tailshock (ES), yoked inescapable (uncontrollable) tailshock (IS), or control treatment (HC) 7 days before fear conditioning in which a tone and footshock were paired. Conditioning was measured 24 h later. In a second experiment rats received ES, IS or HC 24 h after contextual fear conditioning. Extinction then occurred every day beginning 7 days later until a criterion was reached. Spontaneous recovery of fear was assessed 14 days after extinction. IS potentiated fear conditioning when given before fear conditioning, and potentiated fear responding during extinction when given after conditioning. Importantly, ES potently interfered with later fear conditioning, decreased fear responding during fear extinction, and prevented spontaneous recovery of fear. Additionally, we examined if the activation of the ventral medial prefrontal cortex (mPFCv) by ES is critical for the protective effects of ES on later fear conditioning. Inactivation of the mPFCv with muscimol at the time of the initial experience with control prevented ES-induced reductions in later contextual and auditory fear conditioning.Finally, we explored if the protective effects of ES extended to an unconditioned fear stimulus, ferret odor. Unlike conditioned fear, prior ES increased the fear response to ferret odor to the same degree as did IS.Keywords stressor controllability; medial prefrontal cortex; fear conditioning; fear extinction; spontaneous recovery; PTSD The phenomena of Pavlovian fear conditioning and fear extinction have come to be viewed as key processes involved in the development (Mineka and Zinbarg, 2006) and treatment (Rothbaum and Davis, 2003) of anxiety disorders, respectively. In addition to the obvious procedural similarity between fear conditioning/extinction and the conditions that foster Address correspondence to Michael V. Baratta,

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The Affective Neuroscience of Emotion: Automatic Activation, Interoception, and Emotion Regulation

Olsson

Öhman

2009

Handbook of Neuroscience for the Behavioral Sciences

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Inverse amygdala and medial prefrontal cortex responses to surprised faces

Cited by 327 publications

References 22 publications

Amygdala–Prefrontal Disconnection in Borderline Personality Disorder

Amygdala–Prefrontal Disconnection in Borderline Personality Disorder

Controllable versus uncontrollable stressors bi-directionally modulate conditioned but not innate fear

The Affective Neuroscience of Emotion: Automatic Activation, Interoception, and Emotion Regulation

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