Inventory of molecular markers affecting biological characteristics of avian influenza A viruses

Suttie, Annika; Deng, Yi‐Mo; Greenhill, Andrew R.; Dussart, Philippe; Horwood, Paul F.; Karlsson, Erik A.

doi:10.1007/s11262-019-01700-z

Cited by 121 publications

(165 citation statements)

References 324 publications

(226 reference statements)

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“…In recent H9N2 outbreaks in chickens, virus replication was shown in various organs, including trachea, lung, spleen, and kidney, and especially nephrotropism was associated with increased mortality in chickens (Baron et al 2013). Molecular markers of IAV host switching from the natural reservoir-aquatic birds-to poultry are poorly defined (Naguib et al 2015;Mosaad et al 2018;Suttie et al 2019). Most efforts are aimed at understanding interspecies transmission of IAVs from birds to mammals but not among different bird species (Imai et al 2012).…”

Section: Clinical Signs Pathology and Interspecies Transmissionmentioning

confidence: 99%

See 1 more Smart Citation

H9 Influenza Viruses: An Emerging Challenge

Carnaccini

Pérez

2019

Cold Spring Harb Perspect Med

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Influenza A viruses (IAVs) of the H9 subtype are enzootic in Asia, the Middle East, and parts of North and Central Africa, where they cause significant economic losses to the poultry industry. Of note, some strains of H9N2 viruses have been linked to zoonotic episodes of mild respiratory diseases. Because of the threat posed by H9N2 viruses to poultry and human health, these viruses are considered of pandemic concern by the World Health Organization (WHO). H9N2 IAVs continue to diversify into multiple antigenically and phylogenetically distinct lineages that can further promote the emergence of strains with pandemic potential. Somewhat neglected compared with the H5 and H7 subtypes, there are numerous indicators that H9N2 viruses could be involved directly or indirectly in the emergence of the next influenza pandemic. The goal of this work is to discuss the state of knowledge on H9N2 IAVs and to provide an update on the contemporary global situation.

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Section: Clinical Signs Pathology and Interspecies Transmissionmentioning

confidence: 99%

“…(Tse et al 2014). Also, a single amino acid substitution N148D (158, H3 numbering) is important for the attenuation of H9N2 virus disease in mice and chickens (Jin et al 2019;Suttie et al 2019).…”

Section: Salient Features Of the H9 Hamentioning

confidence: 99%

H9 Influenza Viruses: An Emerging Challenge

Carnaccini

Pérez

2019

Cold Spring Harb Perspect Med

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“…Next, we compared the amino acid substitutions found in these newly isolated viruses against molecular markers known to alter viral phenotypes such as virulence, drug resistance and human host adaptation (Table S1) [43][44][45][46][47].…”

Section: Residue and Molecular Analyses Show Limited Presence Of Knowmentioning

confidence: 99%

Genetic and antigenic characterization of influenza A/H5N1 viruses isolated from patients in Indonesia, 2008–2015

et al. 2020

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Since the initial detection in 2003, Indonesia has reported 200 human cases of highly pathogenic avian influenza H5N1 (HPAI H5N1), associated with an exceptionally high case fatality rate (84%) compared to other geographical regions affected by other genetic clades of the virus. However, there is limited information on the genetic diversity of HPAI H5N1 viruses, especially those isolated from humans in Indonesia. In this study, the genetic and antigenic characteristics of 35 HPAI H5N1 viruses isolated from humans were analyzed. Full genome sequences were analyzed for the presence of substitutions in the receptor binding site, and polymerase complex, as markers for virulence or human adaptation, as well as antiviral drug resistance substitutions. Only a few substitutions associated with human adaptation were observed, a remarkably low prevalence of the human adaptive substitution PB2-E627K, which is common during human infection with other H5N1 clades and a known virulence marker for avian influenza viruses during human infections. In addition, the antigenic profile of these Indonesian HPAI H5N1 viruses was determined using serological analysis and antigenic cartography. Antigenic characterization showed two distinct antigenic clusters, as observed previously for avian isolates. These two antigenic clusters were not clearly associated with time of virus isolation. This study provides better insight in genetic diversity of H5N1 viruses during human infection and the presence of human adaptive markers. These findings highlight the importance of evaluating virus genetics for HPAI H5N1 viruses to estimate the risk to human health and the need for increased efforts to monitor the evolution of H5N1 viruses across Indonesia.

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“…during virus replication in humans, and additionally, some human H7N9 virus isolates possess other mammalian-adapting amino acid changes, such as PB2 D701N (Table S1) Czudai-Matwich, Otte, Matrosovich, Gabriel, & Klenk, 2014;Gao et al, 2013;Kageyama et al, 2013;Suttie et al, 2019;Taft et al, 2015;Yamayoshi et al, 2015). Since these mutations have been shown to facilitate avian virus replication in mammalian cells (Suttie et al, 2019;Taft et al, 2015;Zhang et al, 2014), they likely contribute to the lethality of HE29-52 in mice and to the potential of HPAI H7N9 viruses to evolve in mammals and pose a threat to public health.…”

Section: Replicative Properties Of Three H7n9 Avian Influenza Virusmentioning

confidence: 99%

Characterization of H7N9 avian influenza viruses isolated from duck meat products

Mitake

Kiso

et al. 2019

Transbound Emerg Dis

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Avian influenza H7N9 viruses have caused five epidemic waves of human infections since the first human cases were reported in 2013. In 2016, the initial low pathogenic avian influenza (LPAI) H7N9 viruses became highly pathogenic, acquiring multi‐basic amino acids at the haemagglutinin cleavage site. These highly pathogenic avian influenza (HPAI) H7N9 viruses have been detected in poultry and humans in China, causing concerns of a serious threat to global public health. In Japan, both HPAI and LPAI H7N9 viruses were isolated from duck meat products carried illegally and relinquished voluntarily at the border by passengers on flights from China to Japan between 2016 and 2017. Some of the LPAI and HPAI H7N9 viruses detected at the border in Japan were characterized previously in chickens and ducks; however, their pathogenicity and replicative ability in mammals remain unknown. In this study, we assessed the biological features of two HPAI H7N9 virus isolates [A/duck/Japan/AQ‐HE29‐22/2017 (HE29‐22) and A/duck/Japan/AQ‐HE29‐52/2017 (HE29‐52); both of these viruses were isolated from duck meat at the border)] and an LPAI H7N9 virus isolate [A/duck/Japan/AQ‐HE28‐3/2016 (HE28‐3)] in mice and ferrets. In mice, HE29‐52 was more pathogenic than HE29‐22 and HE28‐3. In ferrets, the two HPAI virus isolates replicated more efficiently in the lower respiratory tract of the animals than did the LPAI virus isolate. Our results indicate that HPAI H7N9 viruses with the potential to cause severe diseases in mammals have been illegally introduced to Japan.

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Inventory of molecular markers affecting biological characteristics of avian influenza A viruses

Cited by 121 publications

References 324 publications

H9 Influenza Viruses: An Emerging Challenge

H9 Influenza Viruses: An Emerging Challenge

Genetic and antigenic characterization of influenza A/H5N1 viruses isolated from patients in Indonesia, 2008–2015

Characterization of H7N9 avian influenza viruses isolated from duck meat products

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