Invastigation of persica mouth wash versus doxepin 0.5% oral rinse for chemo-radiotherapy-induced mucositis pain in the treatment of head and neck cancers, a randomized double blind clinical trial

Abstract

<jats:title>Abstract</jats:title> <jats:p>Background: One of the common side effects of radiotherapy and chemotherapy in patients with head and neck cancer is oral mucositis. This painful complication restricts the ability to eat and drink and increases the risk of oral infections. The aim of this study was to investigate the effect of doxepin oral rinse 0.5% in comparison with persica mouthwash on reducing the pain of oral mucositis in patients with head and neck cancer after radiotherapy and chemotherapy. Methods: This clinical trial was performed on 56 patients admitted in the oncology ward of Shahid Sadoughi Hospital and Shahid Ramezanzadeh radiotherapy center in Yazd, who received more than 45 gray of radiation and had mucositis and their pain score was more than 4 on the basis of the Visual Analogue Scale (VAS). Patients were randomly divided into two groups of persica and doxepin 0.5%. The data collection tool was a questionnaire including visual analogue scale for pain, taste satisfaction and possible complications. Data were analyzed by using SPSS19 software and Chi-square test. Results: There was no significant difference between the mean score of pain in doxepin and persica groups 5,15,30, 120,240 minutes and 24 hours after taking the mouthwash; just in the doxepin group, the mean of pain reduction 60 minute after taking the mouthwash was higher than persica group (P&gt; 0.05). There was no significant difference between the mean score of burning sensation in doxepin and persica groups30,60,120,240 minutes and 24 hours after taking the mouthwash; just in the pesica group, the mean of burning sensation reduction 5,15minutes after taking the mouthwash was lower than doxepin group The level of taste satisfaction and drowsiness in the doxepin group was significantly higher than persica group. (P &gt;0.05) Conclusion: Persica mouthwash, like doxepin mouthwash, was effective in reducing the mucositis pain in patients and just in the doxepin group reduction in pain after 60 minutes was higher than perisca group</jats:p>

Evaluation of analgesic effects of doxepin cream in patients with knee osteoarthritis

“…It is very important to use drugs other than painkillers and anti-in ammatory steroids with similar and even better effects with fewer side effects. Many studies have been conducted to investigate the effect of oral doxepin on pain, which has shown the reduction of pain with the use of this drug in various diseases [30][31][32]. It has been suggested in studies that TCA drugs such as doxepin, when used topically, can show analgesic effects with different mechanisms, including local anesthetic effects and central effects [23].…”

Increasing oral hygiene behavior through correct habits of miswak on students of secondary school

“…Until now, the most effective mechanical way to clean plaque is tooth brushing 7 . One alternative in brushing teeth is using miswak 18 .…”

“…One alternative in brushing teeth that is usually used by Muslims is miswak. Miswak is a plant from the Salvadoraceae family 7 . Several previous studies have reported the presence of antibacterial substances in miswak against cariogenic bacteria and periodontal pathogens, especially Bacterioides species [8,9].…”