Invasiveness of Pituitary Adenomas

Sautner, Doris; Saeger, Wolfgang

doi:10.1016/s0344-0338(11)80161-5

Cited by 48 publications

(21 citation statements)

References 6 publications

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“…In contrast, adenoma cells were never seen beyond the last row of enlarged cell-cords of the transition zone. These data show that adenomatous and normal cells intermingle over a wide area only on the adenomatous side of the Our results are at variance with other observations reporting that, even when a boundary could be seen between the two tissues, there could be gross interchange of cells on both sides of the boundary (Wrightson 1978(Wrightson , 1980Sautner and Saeger 1991). The well-established efficiency of conservative resection of pituitary adenomas can be explained on the basis of our morphological data which imply that, provided that the transition zone is removed together with the tumour tissue, no nests of tumour cells remain.…”

Section: Discussioncontrasting

confidence: 78%

“…The majority of pituitary tumours are considered to be benign and slow-growing (Landolt et al 1987) and metastatic pituitary carcinomas are exceptional (Kovacs and Horvath 1986;Mountcastle et al 1989). However, radiological, macroscopic and microscopic findings show that a large proportion of these benign tumours display locally aggressive behaviour, invading surrounding structures such as the dura mater, the optic chiasm, the diaphragma sellae and the sphenoidal or cavernous sinus (Jefferson 1954;Martins et al 1965;Lundberg et al 1977;Scheithauer et al 1986;Selman et al 1986;Sautner and Saeger 1991). Few studies have been devoted to the interactions between adenoma and surrounding anterior pituitary tissues during adenoma growth.…”

Section: Introductionmentioning

confidence: 99%

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Interactions between normal and tumoral tissues at the boundary of human anterior pituitary adenomas

Farnoud

Kujas

Derome

et al. 1994

Vichows Archiv A Pathol Anat

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We studied the boundary between adenoma and peritumoral anterior pituitary tissues in order to understand their mutual interactions during tumour progression. We selected 18 adenomas of different secretory type, grade and invasiveness in which fragments of peritumoral anterior pituitary were still attached to the adenoma. Immunohistochemistry was performed on serial sections with markers of the basement membranes (type IV collagen), the hormone-producing cells of the normal and neoplastic anterior pituitary, and the folliculo-stellate cells (S-100 protein). In passing from tumour to gland, localized areas of passive compression of the normal gland were seen in only 3 cases. In all the tumours, the boundary consisted partly or solely of a transitional zone characterized by the presence of enlarged cell-cords. Openings in the basement membrane of these enlarged cell-cords were seen in contact with the tumour tissue. Normal and neoplastic cells intermingled in the transitional zone. Normal residual cells could be seen in the central area of the tumour but no adenomatous cells were observed in the gland around the tumour. Folliculo-stellate cells were concentrated in the vicinity of the transition zone. These findings favour the existence of an active process of adenoma expansion within the normal parenchyma, without noticeable infiltration of tumour cells into surrounding gland.

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Section: Discussioncontrasting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Interactions between normal and tumoral tissues at the boundary of human anterior pituitary adenomas

Farnoud

Kujas

Derome

et al. 1994

Vichows Archiv A Pathol Anat

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“…Os tumores hipofisários apresentam, em sua grande maioria, comportamento benigno, embora Sautner e Saeger (12), examinando um grande número de tumores, tenham encontrado algum grau de invasão local em 42% deles. Os adenomas hipofisários, de modo geral, são muito mais freqüentes no sexo feminino e os corticotrofinomas são cerca de quatro vezes mais freqüentes em mulheres.…”

Section: Tumorigênese Hipofisáriaunclassified

“…Entretanto, quase a metade desses tumores apresenta indícios histológicos de agressividade, como invasão local. (12). Avaliando o fenômeno de apoptose nestes tumores, Green e cols.…”

Section: Apoptoseunclassified

Etiopatogênese Molecular dos Tumores Corticotróficos

Antonini

Castro

2002

Arq Bras Endocrinol Metab

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Molecular Etiopathogenesis of Corticotrophic Tumors.Corticotropinomas represent approximately 80% of the etiology of Cushing's syndrome in adults. In the past decade remarkable advances in the knowledge of the normal anterior pituitary development, in the pathogenesis of the pituitary tumors, as well as in the factors involved in the tumoral progression have been made. General principles of tumorigenesis are valid in corticotrophic tumors and it is clear that this is a multistep and multifactorial process, resulting from the interaction of initiating and promoting events. Most of the oncogenes and tumor suppressor genes related to other tumor types do not seem to contribute in this process, although abnormal expression of some of these genes, like PTTG, p53 and p16 can be related to a more aggressive phenotypic behavior. Investigation of the corticotrophicspecific regulatory pathways, mainly the structure and expression of the CRH, AVP, and GR receptor genes has also not shown significant abnormalities. However, it is possible that disruption in regulatory regions of these genes or in their transcription factors could be involved. Future studies in the regulatory mechanisms of both normal and tumoral corticotrophic cells could contribute in defining better

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“…Os adenomas hipofisários invasivos têm maior atividade proliferativa que os não-invasivos (13,14); os invasivos são, geralmente, os adenomas tireotróficos e adenomas corticotróficos não-secretores (15,16).…”

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Avaliação da atividade secretora, proliferação celular e expressão da proteína p27 em tumores hipofisários

Lima

Rios

Oliveira

et al. 2000

Arq Bras Endocrinol Metab

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A finalidade deste estudo foi avaliar a atividade secretora, proliferação celular e inibição do ciclo celular das neoplasias hipofisárias. Os tecidos foram obtidos de 13 pacientes incluindo acromegalia (n=5), adenomas não-secretores (n=4), hiperprolactinemia (n=3) e doença de Cushing (n=1). Os espécimes foram examinados por técnica imuno-histoquímica com anticorpos anti-ACTH, anti-TSH, anti-LH, anti-FSH, anti-PRL, anti-hGH, anti-MIB-1 (análise da proliferação celular) e anti-p27 (análise da inibição do ciclo celular). A expressão imuno-histoquímica quanto à atividade secretora nos tumores hipofisários demonstrou que todos produziam mais que um hormônio. As células positivas para o marcador de proliferação celular MIB-1 mostraram-se presentes em aproximadamente 46% dos casos. A maior taxa proliferativa foi encontrada nos tumores com quadro clínico de acromegalia (80% dos casos). A taxa de positividade para a proteína p27 foi de aproximadamente 38%, sendo, em média, maior no tumor responsável pela doença de Cushing. Esses resultados demonstram que os adenomas multisecretores são relativamente comuns. Os índices de proliferação celular baixos e os níveis de p27 próximos àqueles observados em tecidos normais expressam o baixo nível de proliferação celular destes tumores. ABSTRACTThe aim of this study was to evaluate the secretory activity, cell proliferation and inhibition of the cell cycle of pituitary neoplasm. Tissues were obtained from 13 patients presenting with acromegaly (n=5), non-secreting adenomas (n=4), hyperprolactinemia (n=3) and Cushing's disease (n=1). Specimens were examined by an immunohistochemical technique using anti-ACTH, anti-TSH, anti-LH, anti-FSH, anti-PRL, anti-hGH, anti-MIB-1 (analysis of cell proliferation) and anti-p27 (analysis of cell cycle inhibition) antibodies. Regarding secretory activity all tumors produced more than one hormone. Cells positive for MIB-1 were present in approximately 46% of the cases. The highest incidence of proliferation was found in those presenting acromegaly (80% of the cases). Expression of the p27 protein was positive in approximately 38%, being on an average, highest in Cushing's disease. These results demonstrate the presence of multisecretory pituitary adenomas, a relative common finding. The relatively low cell proliferation indexes and the near normal tissue levels of p27 confirm that these tumors grow at a rather slow rate.

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Invasiveness of Pituitary Adenomas

Cited by 48 publications

References 6 publications

Interactions between normal and tumoral tissues at the boundary of human anterior pituitary adenomas

Interactions between normal and tumoral tissues at the boundary of human anterior pituitary adenomas

Etiopatogênese Molecular dos Tumores Corticotróficos

Avaliação da atividade secretora, proliferação celular e expressão da proteína p27 em tumores hipofisários

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