Invasive thymoma with intracaval growth into the right atrium

Yokoi, Kohei; Miyazawa, Naoto; Mori, Kiyoshi; Saito, Yoshikuni; Tominaga, Keigo; Imura, George; Shimamura, Kayako; Hirotani, Takashi; Kiso, I

doi:10.1016/0003-4975(92)90281-8

Cited by 29 publications

(14 citation statements)

References 6 publications

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“…Recently, to patients with advanced invasive thymoma, multidisciplinary treatment including radical resection, pre-or post-operative chemotherapy and radiotherapy, has been considered effective (28). In our study, postoperatively, all the patients underwent routinely prophylactic radiotherapy, but chemotherapy or preoperative radiotherapy depends on their individual situations (chemotherapy criteria: locally advanced thymoma; solitary metastasis or ipsilateral pleural metastasis; extrathoracic metastasis.…”

Section: Discussionmentioning

confidence: 88%

Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases

Sun

Shi

et al. 2017

J. Thorac. Dis.

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Background: Discuss an appropriate strategy for treatment of invasive thymoma invading adjacent great vessels.Methods: A retrospective study on 25 patients with invasive thymoma invading neighboring great vessels was performed. The corresponding data including clinical presentation, operation procedure, adjuvant radiochemotherapy and follow-up were reviewed. Postoperatively, three cases suffered from pulmonary infection, and three cases had haemothorax, chylothorax and atelectasis, respectively. Two patients died due to acute respiratory distress syndrome within 90 days after the surgery. Within the remaining patients, 11 cases (44%) experienced a relapse and finally 8 (32%) patients died. Compared to R1 resection group, R0 resection group had a better prognosis (Log-rank P=0.0196). The 3-and 5-year survival rates were 79.6% and 59.1%, with median survival time of 84 months.Conclusions: Reconstruction of mediastinal vessels for invasive thymoma is a feasible technology method.Radical resection of the tumor with involved neighboring structures is the key to prolong overall survival for patients suffered from invasive thymoma.

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Section: Discussionmentioning

confidence: 88%

Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases

Sun

Shi

et al. 2017

J. Thorac. Dis.

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“…It has also been shown that multimodality treatment of patients with neoadjuvant chemotherapy, and surgery, followed by additional adjuvant chemotherapy plus radiotherapy, may improve the survival of patients with locally advanced thymoma [51]. In a case report by Yokoi and colleagues, a locally advanced thymoma invading the heart and great vessels was successfully treated with preoperative/postoperative cisplatin and doxorubicin, in addition to postoperative radiotherapy, with good results [52]. Furthermore, induction chemotherapy may be effective at downstaging thymoma, allowing patients initially thought not to be surgical candidates to undergo resection.…”

Section: Multimodality Therapymentioning

confidence: 99%

Thymoma: Update for the New Millenium

et al. 2001

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USA. Telephone: 210-616-5648; Fax: 210-949-5085; e-mail: cthomas@saci.org www: cancerdata.com Received October 11, 2000; accepted for publication May 11, 2001. ©AlphaMed Press 1083-7159/2001 INTRODUCTIONThymic tumors are common among anterior mediastinal tumors in adults. The vast majority of thymic lesions are thymoma [1]. Thymoma is relatively unique among tumors in that the prognosis appears to be more closely related to the invasive characteristics seen at operation rather than histological appearance. Indeed, the degree of encapsulation and invasion of adjacent tissues define malignancy for these tumors rather than the histologic appearance of the tumor cells [2]. Current treatment of thymoma is often multidisciplinary in nature, and has evolved based upon a growing number of studies to date. These studies have looked at various outcomes based upon associated patient syndromes, tumor histology, and tumor staging, as well as various surgical, radiotherapeutic, chemotherapeutic, and multimodality trials. These studies form the basis of this review.

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“…Local invasion occurs most commonlyinto the pleura (30%), pericardium (25%), lungs (8%), and recurrent laryngeal nerve (4%), but invasion into the intracardiac and great vessels is extremely rare (3). Only a few cases of intracardiac extension of thymomahave been reported in the English literature (3)(4)(5)(6)(7)(8)(9). Wereport a case of invasive thymomawhich extended into the right atrium and right ventricle, causing right ventricular inflow tract obstruction.…”

Section: Introductionmentioning

confidence: 99%

Successful Resection of Intracardiac Invasive Thymoma with Right Ventricular Inflow Tract Occlusion.

et al. 2000

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A 72-year-old man presenting with the superior vena cava syndromeand intracardiac mass wasadmitted to our hospital. The mass was resected and confirmed to be invasive thymoma. Three years later, he was re-admitted with recurrence into the intracardiac space without any changes in the anterior mediastinum mass. The mass occupied the right atrial cavity and protruded into the right ventricle, causing right ventricular inflow tract obstruction. He underwent re-operation and irradiation. His postoperative course was uneventful, and he has remained alive. Invasive thymomawith intracardiac extension is extremely rare.

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Invasive thymoma with intracaval growth into the right atrium

Cited by 29 publications

References 6 publications

Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases

Reconstruction of mediastinal vessels for invasive thymoma: a retrospective analysis of 25 cases

Thymoma: Update for the New Millenium

Successful Resection of Intracardiac Invasive Thymoma with Right Ventricular Inflow Tract Occlusion.

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