Invasive Scopulariopsis alboflavescens infection in patient with acute myeloid leukemia

Kurata, Keiji; Nishimura, Shigeo; Ichikawa, Hiroya; Sakai, Rina; Mizutani, Yu; Takenaka, Katsuto; Kakiuchi, Seiji; Miyata, Yoshiharu; Kitao, Akihito; Yakushijin, Kimikazu; Kawamoto, Shinichiro; Yamamoto, Katsuya; Ito, Mitsuhiro; Matsuoka, Hiroshi; Tokimatsu, Issei; Kamei, Katsuhiko; Minami, Hironobu

doi:10.1007/s12185-018-2496-1

Cited by 9 publications

(9 citation statements)

References 27 publications

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“… AMB and voriconazole combination therapy was not successful and the patient died. 251 S. brevicaulis AML Bronchial invasion that leads to mediastinal emphysema, bronchial bleeding, and bronchial obstruction before finally spreading to the entire lung. The patient died because it was estimated that the patient had respiratory aspergillosis infection, and the optimal treatment was delayed.…”

Section: Trichosporonosismentioning

confidence: 99%

<p>An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies</p>

Shariati¹,

Moradabadi²,

Chegini³

et al. 2020

IDR

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In patients with hematologic malignancies due to immune system disorders, especially persistent febrile neutropenia, invasive fungal infections (IFI) occur with high mortality. Aspergillosis, candidiasis, fusariosis, mucormycosis, cryptococcosis and trichosporonosis are the most important infections reported in patients with hematologic malignancies that undergo hematopoietic stem cell transplantation. These infections are caused by opportunistic fungal pathogens that do not cause severe issues in healthy individuals, but in patients with hematologic malignancies lead to disseminated infection with different clinical manifestations. Prophylaxis and creating a safe environment with proper filters and air pressure for patients to avoid contact with the pathogens in the surrounding environment can prevent IFI. Furthermore, due to the absence of specific symptoms in IFI, rapid and accurate diagnosis reduces the mortality rate of these infections and using molecular techniques along with standard mycological methods will improve the diagnosis of disseminated fungal infection in patients with hematologic disorders. Amphotericin B products, extended-spectrum azoles, and echinocandins are the essential drugs to control invasive fungal infections in patients with hematologic malignancies, and according to various conditions of patients, different results of treatment with these drugs have been reported in different studies. On the other hand, drug resistance in recent years has led to therapeutic failures and deaths in patients with blood malignancies, which indicates the need for antifungal susceptibility tests to use appropriate therapies. Life-threatening fungal infections have become more prevalent in patients with hematologic malignancies in recent years due to the emergence of new risk factors, new species, and increased drug resistance. Therefore, in this review, we discuss the different dimensions of the most critical invasive fungal infections in patients with hematologic malignancies and present a list of these infections with different clinical manifestations, treatment, and outcomes.

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Section: Trichosporonosismentioning

confidence: 99%

<p>An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies</p>

Shariati¹,

Moradabadi²,

Chegini³

et al. 2020

IDR

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“…In the immunocompetent, Scopulariopsis commonly causes onychomycosis, keratitis and localised skin infection. It is increasingly reported in the immunosuppressed and can cause lung, sinus, soft tissue and disseminated infection 262–265 …”

Section: Question 8 What Are the Emerging Nam?mentioning

confidence: 99%

“…It is increasingly reported in the immunosuppressed and can cause lung, sinus, soft tissue and disseminated infection. [262][263][264][265] Histological specimens show dichotomously branched septate hyphae. 107,262,264 Definitive diagnosis depends on culture from infected tissue or body fluid obtained from a normally sterile site by sterile procedure.…”

Section: Paecilomyces Variotiimentioning

confidence: 99%

“…In vitro synergy has been demonstrated with combinations of posaconazole and terbinafine, posaconazole and caspofungin, amphotericin B and caspofungin, and also to three drugs in combination. 273,274 L-AMB (3-10 mg/kg/day) and voriconazole, 263 voriconazole alone (i.v. and then oral step-down therapy), and lipid formulations of amphotericin B with other antifungal agents, 165,266 can be moderately recommended (Moderate recommendation, Level III evidence).…”

Section: Paecilomyces Variotiimentioning

confidence: 99%

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Consensus guidelines for the diagnosis and management of invasive fungal disease due to moulds other than Aspergillus in the haematology/oncology setting, 2021

Bupha‐Intr

Butters

Reynolds

et al. 2021

Internal Medicine Journal

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Invasive fungal disease (IFD) due to moulds other than Aspergillus is a significant cause of mortality in patients with malignancies or post haemopoietic stem cell transplantation. The current guidelines focus on the diagnosis and management of the common non‐Aspergillus moulds (NAM), such as Mucorales, Scedosporium species (spp.), Lomentospora prolificans and Fusarium spp. Rare but emerging NAM including Paecilomyces variotii, Purpureocillium lilacinum and Scopulariopsis spp. are also reviewed. Culture and histological examination of tissue biopsy specimens remain the mainstay of diagnosis, but molecular methods are increasingly being used. As NAM frequently disseminate, blood cultures and skin examination with biopsy of any suspicious lesions are critically important. Treatment requires a multidisciplinary approach with surgical debridement as a central component. Other management strategies include control of the underlying disease/predisposing factors, augmentation of the host response and the reduction of immunosuppression. Carefully selected antifungal therapy, guided by susceptibility testing, is critical to cure. We also outline novel antifungal agents still in clinical trial which offer substantial potential for improved outcomes in the future. Paediatric recommendations follow those of adults. Ongoing epidemiological research, improvement in diagnostics and the development of new antifungal agents will continue to improve the poor outcomes that have been traditionally associated with IFD due to NAM.

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“…In these populations, soft tissue infection, invasive sinusitis, pneumonia, and disseminated disease are the most common clinical manifestations. [85][86][87][88][89][90][91] In case reports of patients with respiratory tract involvement, pulmonary nodules, cavities, dense consolidations, ground glass opacities, and pleural effusions are described. 86,[90][91][92] Other clinical manifestations include endocarditis, 93,94 mastoiditis, 85 cerebral abscesses, 95 and peritonitis.…”

Section: Epidemiology and Clinical Manifestationsmentioning

confidence: 99%

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

Jacobs

Wengenack

Walsh

2020

Semin Respir Crit Care Med

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Hyaline molds, widely distributed in nature, are an important and increasing cause of invasive fungal infections in humans, likely due to an expanding population of immunosuppressed hosts, increases in antifungal resistance, and improvements in laboratory diagnostics. Sinopulmonary disease and disseminated infection are common manifestations in neutropenic patients and transplant recipients, whereas, catheter-related and localized soft tissue infections predominate in immunocompetent hosts. These organisms are not reliably differentiated based on their morphology in tissue; rather, efforts should be made to establish a microbiologic diagnosis via culture or molecular-based methods to guide antifungal management and inform prognosis. Herein, we review the epidemiology, clinical manifestations, diagnosis, and management of these opportunistic pathogens known to cause hyalohyphomycoses: Scedosporium spp., Lomentospora prolificans, Fusarium spp., Scopulariopsis spp., Arthrographis kalrae, Trichoderma spp., Acremonium spp., Paecilomyces variotii, Purpureocillium lilacinum, and Penicillium species.

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Invasive Scopulariopsis alboflavescens infection in patient with acute myeloid leukemia

Cited by 9 publications

References 27 publications

<p>An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies</p>

<p>An Overview of the Management of the Most Important Invasive Fungal Infections in Patients with Blood Malignancies</p>

Consensus guidelines for the diagnosis and management of invasive fungal disease due to moulds other than Aspergillus in the haematology/oncology setting, 2021

Non-Aspergillus Hyaline Molds: Emerging Causes of Sino-Pulmonary Fungal Infections and Other Invasive Mycoses

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