Invasive pulmonary aspergillosis/pseudomonas

Abstract

A 47-year-old Caucasian man on long-standing antifungal therapy for chronic necrotising aspergillosis and a history of recurrent pseudomonas pneumonias presented to the outpatient pulmonary clinic with dyspnoea and chest discomfort for 3 days. A CT angiography of the chest demonstrated angioinvasion from the previously noted left upper lobe cavitary lesion into the left main pulmonary artery, along with new consolidating lesions. Due to the high risk for massive haemoptysis, he was evaluated by thoracic surgery and underwent a successful left pneumonectomy. As invasive pulmonary aspergillosis is associated with high mortality, surgical intervention should always be considered, especially in those who develop extensive disease, despite being on aggressive antifungal therapy. Though minimally described in literature, invasive pulmonary pseudomonas also carries a high mortality risk. In our patient, cultures from the resected lung only demonstrated Pseudomonas aeruginosa.

Research Progress on Diagnosis and Treatment of Bronchiectasis with Massive Hemoptysis

“…A complete laboratory examination can help us to identify possible hemoptysis caused by other causes, such as abnormal coagulation, and evaluate complications caused by hemoptysis. Sputum culture is a very important examination, and invasive bacteria such as Pseudomonas aeruginosa or fungi (such as Aspergillus) have been shown to be a common cause of hemoptysis [17]. And Pseudomonas aeruginosa is a common co-infection flora in bronchi, so perfecting sputum culture can help to give corresponding anti-infection treatment.…”