Invasive Primary Aspergillosis of the Lung with Cerebral Metastasis and Complete Recovery

Conen, Patrick E.; Walker, George R.; Turner, James A.; Field, P. L.

doi:10.1378/chest.42.1.88

Cited by 33 publications

(5 citation statements)

References 14 publications

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] Serum levels of CyA were determined routinely, with therapeutic level ranging from 600 to 1000 ng/ml. Azathioprine was frequently used in combination with CyA and prednisone.…”

Section: Methodsmentioning

confidence: 99%

CNS aspergillosis in organ transplantation: a clinicopathological study.

Torre‐Cisneros

López

Kusne

et al. 1993

Journal of Neurology, Neurosurgery & Psychiatry

123

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The clinical characteristics and neuropathological findings of 22 organ transplant recipients with CNS aspergillosis were reviewed. Thirteen patients had liver, six kidney, two heart and one had cluster transplants. The most frequent neurological symptoms were alteration of mental status (86%), seizures (41%) and focal neurological deficits (32%). Meningeal signs were less common (19%). Aspergillus spp invasion of the blood vessels with subsequent ischaemic or haemorrhagic infarcts, and solitary or multiple abscesses were the predominant neuropathological findings. The lungs were the probable portal of entry; however, isolated CNS aspergillosis was seen in two patients. Antemortem diagnosis of the infection was made in half of the patients. Concomitant diabetes mellitus was noted in 590/o of the patients and bacterial or other severe infections in 86%. No specific clinical or pathological pattern could be identified among patients with different types of organ transplants. In addition CNS aspergillosis was preceded by organ rejection and the need for intense immunosuppression and retransplantation in the majority of the patients.

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Section: Methodsmentioning

confidence: 99%

CNS aspergillosis in organ transplantation: a clinicopathological study.

Torre‐Cisneros

López

Kusne

et al. 1993

Journal of Neurology, Neurosurgery & Psychiatry

123

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“…Human brain abscesses due to fungi (2,5,7,15,16) have been caused by Aspergillus spp. (2,5,8,12,23,27, Candida spp. (5), Cryptococcus neoformans (5), various zygomycetes (22), and such dematiaceous pathogens as Xylohypha bantiana (4,9,19,20,24) and, more rarely, Bipolaris hawaiiensis (11,21).…”

Section: Discussionmentioning

confidence: 99%

Cerebral phaeohyphomycosis caused by Chaetomium globosum in a renal transplant recipient

et al. 1989

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A 32-year-old male patient developed headaches, vomiting, blurring of vision, and focal seizures of the left side of the face 2 months after a renal transplant. He developed a brain abscess and died. Direct KOH examination of the brain tissue demonstrated hyaline as well as dematiaceous, septate hyphae. Histologic examination of brain sections revealed polymorphous fungal elements consisting of septate, dark-pigmented hyphae, intercalary and terminal swollen fungal cells, and budding yeastlike cells characteristic of phaeohyphomycosis. Chaetomium globosum was isolated from the brain tissue on all of the fungal media used. This case represents the first histologically and culturally documented phaeohyphomycotic brain infection caused by C. globosum.

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“…Amphotericin B has been used in a few cases (Newcomer, Sternberg, Wright, and Reisner, 1959;Peer, 1960;Conen, Walker, Turner, and Field, 1962;Utz and Andriole, 1962) and despite its toxicity it has been recommended in the treatment of this condition (American Thoracic Society Committee on Therapy, 1963).…”

Section: Discussionmentioning

confidence: 99%