Invasive prenatal diagnosis during COVID-19 pandemic

Carbone, Luigi; Raffone, Antonio; Sarno, Laura; Travaglino, Antonio; Saccone, Gabriele; Gabrielli, Olimpia; Sirico, Angelo; Genesio, Rita; Castaldo, Giuseppe; Capponi, Alessandra; Zullo, Fulvio; Rizzo, Giuseppe; Maruotti, Giuseppe Maria

doi:10.1007/s00404-021-06276-4

Cited by 13 publications

(10 citation statements)

References 12 publications

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“…Guidelines and advices were soon released by experts and subspecialty societies to direct obstetrical and gynecological management [3][4][5][6][7][8][9][10][11][12][13][14][15]. Interestingly, during the lockdown period, a significant decrease in admissions to the emergency units was also found for obstetric-gynecological conditions [16][17][18][19][20][21], and even for important tests, such as invasive prenatal diagnosis, a drop in the number of procedures was noted [22], clearly showing that pregnant women were more concerned than others of contracting the infection and suffering from the COVID-19 disease [23,24]. Moreover, reproductive medicine had to cease treatment unless for fertility preservation due to oncologic reasons, with consequences also on fertility and natality rates, opening a debate on the urgency to reduce time to pregnancy in women with poor prognosis [25][26][27][28][29].…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 infection: a single center experience

Guida¹,

Carbone²,

Ferrara³

et al. 2022

It Journ Gyn Obs

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Background:The aim of this study was to evaluate maternal and perinatal outcomes of pregnant women affected by COVID-19 during the first pandemic wave in a third level university hospital of southern Italy. Methods:This was a single-center, cohort study on SARS-CoV-2 in pregnancy. Pregnant women with laboratory-confirmed SARS-COV-2 from August 1, 2020 to January 1, 2021 from University of Naples Federico II were included in the study. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was the incidence preterm birth.Results: 249 singleton pregnancies, positive to SARS-COV-2 at RT-PCR nasal and pharyngeal swab, were included in the study. Mean gestational age at diagnosis was 31.0 ± 6.7 weeks, with 2.4% of women being diagnosed in the first, 14.1% in the second and 83.5% in the third trimester of pregnancy. The vast majority of the women received therapy with low molecular weight heparin (88.8%). 47 women (18.9%) required oxygen therapy. The rate of admission to the maternal intensive care unit was 2.8%. There was one case of maternal death, accounting for a maternal mortality rate of 0.4%. Out of the 249 ended pregnancies, we reported two spontaneous abortions and two stillbirths. Among the 245 live-born babies, no neonatal deaths were recorded. All babies were tested negative at RT-PCR nasal and pharyngeal swab. The incidence of preterm delivery before 37 weeks was 10%.Conclusion: SARS-COV-2 infection in pregnant women during the first pandemic wave in the South of Italy was associated with relative low rates of maternal and perinatal adverse outcome.

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Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 infection: a single center experience

Guida¹,

Carbone²,

Ferrara³

et al. 2022

It Journ Gyn Obs

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“…[3] In obstetrics and gynecology, COVID-19 pandemic is associated with significantly higher risk of maternal and perinatal complications, [4][5][6][7][8][9][10][11][12][13][14][15] but also chal-lenges and issues about organizing labor and delivery unit, [16][17][18] training program, [19] and vaccination. [20][21][22][23] Family planning services may be also affected by COVID-19 pandemic. [24] A health system response for family planning services during the pandemic, including telemedicine, is important to avoid unwanted pregnancies and prevent additional mortality and morbidity of women.…”

Section: Introductionmentioning

confidence: 99%

Impact of COVID-19 on termination of pregnancy

Ferrara¹,

Sglavo²,

Morra³

et al. 2022

Perinat J

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Objective: To evaluate the impact of COVID-19 pandemic on termination of pregnancy. Methods: This was a retrospective study aimed to assess the impact of COVID-19 pandemic on termination of pregnancy in a single center in Italy. Consecutive data on pregnant women who requested induced termination of pregnancy (I-TOP) from February 2018 to December 2021 were included in a dedicated database. The data were divided into two groups according to the COVID-19 outbreak. Women who requested I-TOP from February 2018 to January 2020 were included into the group ‘before COVID-19 pandemic’. Women who requested I-TOP from February 2020 to January 2022 were included into the group ‘during COVID-19 pandemic’. Indications for I-TOP included elective abortion and therapeutic for fetal or maternal indication. Results: A total of 2578 women were included in the study. Of them, 1637 had I-TOP before COVID-19, and 941 had I-TOP during COVID-19. During the pandemic, the request for elective abortion decreased from 76.2% to 67.7% (p<0.01). Therapeutic abortion were performed in 141/693 cases in the first trimester, and in 552/693 cases in the second trimester. Overall, 91 were for maternal indications and 602 for fetal indications. No differences were noticed between before and during pandemic (p=0.99). Follow-up visits two weeks after abortions were offered to all women. However, only 35.5% women visited for follow-up during pandemic vs. 65.0% before COVID-19 (p<0.01). Conclusion: The COVID-19 pandemic had impact on access to abortion services, reducing request for elective abortion and post-abortion follow-up visits.

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“…This is a trend that we have observed worldwide. In a multicentre research trial carried out in Italy from March to May 2020, the average number of procedures performed in four centres decreased by over 20% in comparison with the same period in 2019 [ 19 ]. A similar analysis was conducted in a Turkish centre, in which, from11 March 2020 to 30 June 2020, the number of invasive diagnostic procedures decreased by one third when compared with the same period before the pandemic [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Implementation of the Publicly Funded Prenatal Screening Programme in Poland during the COVID-19 Pandemic: A Cross-Sectional Study

Czuba

Młodawski

Kajdy

et al. 2022

JCM

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The COVID-19 pandemic in 2020 affected the entire healthcare system in Poland, causing medical personnel to be relocated to other duties and limiting patients’ contacts with healthcare professionals. A large part of the planned diagnostics and treatment was delayed due to lack of equipment and personnel. Against this background, we analysed the implementation of the publicly funded prenatal screening programme (PSP) in Poland compared to the previous year. This is a cross-sectional study. We used nationwide datasets on the implementation of the prenatal testing programme over the period 2019–2020, datasets from the Statistics Poland on birth and the data on the development of the COVID-19 epidemic in Poland. In the year 2020, we observed a 12.41% decrease in woman enrolled to the programme compared to 2019. However, the decrease concerned only women under 35 years of age. With respect to the number of deliveries in the calendar year, the number of patients enrolled in the programme decreased by 3% (31% vs. 34%, p < 0.001). We also observed an increase in estriol measurements per the number of patients included in the programme, and a reduction in the number of PAPP-A tests in the first trimester, which proves an increased share of the triple test in the prenatal diagnosis of chromosomal aberrations. With respect to the number of deliveries, the number of amniocentesis procedures performed under PSP decreased by 0.19% (1.8% vs. 1.99%, p < 0.0001). In 2020, compared to the previous year, the number of patients included in the prenatal testing programme in Poland decreased. In terms of the number of births in Poland, the number of integrated screening tests also decreased, at the expense of increasing the percentage of triple tests. There were also significant reductions in the number of invasive diagnostic tests.

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Invasive prenatal diagnosis during COVID-19 pandemic

Cited by 13 publications

References 12 publications

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 infection: a single center experience

Maternal and Perinatal Outcomes of Pregnant Women with SARS-CoV-2 infection: a single center experience

Impact of COVID-19 on termination of pregnancy

Implementation of the Publicly Funded Prenatal Screening Programme in Poland during the COVID-19 Pandemic: A Cross-Sectional Study

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