Invasive pneumococcal infections: a clinical and microbiological analysis of 53 patients in Taiwan

Cy, Lee; Ch, Chiu; Huang, Yifei; Pw, Chung; Lh, Su; Tl, Wu; Lin, Tao

doi:10.1046/j.1469-0691.2003.00589.x

Cited by 13 publications

(3 citation statements)

References 16 publications

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“…Older age has not been associated with higher incidence only, but also with more severe disease [13] and higher mortality rates [13][14][15]. The pattern of age-related incidence and mortality which was noted in our population as well as in terms of gender predominance, males predominated was similar to what has been reported in other countries, such as United States [10], Lebanon [12], and Taiwan [16][17].…”

Section: Discussionsupporting

confidence: 85%

Epidemiological and Clinical Characteristics of Streptococcus pneumoniae Infections in a Tertiary Care Center in Bahrain (2010-2014)

AlSalaman

Alshehabi

Salah

et al. 2017

int. arab. j antimicrob. agents

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Objective: To describe the epidemiology of invasive and non-invasive pneumococcal disease during a 5-year period in a major hospital in Bahrain. Design and Setting: Retrospective study of cases of pneumococcal diseases among patient ≥ 14 years old during a five-year period (2010-2014), who attended Salmaniya Medical Complex, Bahrain. Patients and Methods: Laboratory data was obtained on Streptococcus pneumoniae isolates. Patients ≥14 years old of age, both inpatient and outpatient with cultures positive for Streptococcus pneumoniae were included. Only samples from blood, cerebrospinal fluid (CSF), pleural fluid, sputum, deep tracheal aspirate (DTA), bronchial wash, eye discharge and middle ear fluid were included. Demographics and clinical records from medical files were then reviewed. Results: A total of 130 culture samples met the inclusion criteria and were analyzed. One-hundred twenty-six patients with pneumococcal disease were identified; with 65% being non-invasive and 35% being invasive pneumococcal disease. Overall, non-bacteremic Pneumonia was the most frequent manifestation, followed by bacteremia. Pneumococcal disease was more common among male patients (62.7%). Mean age was 57.67 (15-95 years). The most common comorbidities were hypertension, Diabetes Mellitus followed by cardiovascular disease. Twenty-seven patients received mechanical ventilation during their admission, 13 patients were admitted to the intensive care unit, and 6 patients developed para-pneumonic effusion as a complication. In-hospital Mortality rate was 13.5%. Conclusion: This study supports the current literature where pneumococcal infection is more prevalent in elderly and those with comorbidities. Mortality was related to age, certain chronic medical illness, admission to intensive care unit and need for mechanical ventilation.

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Section: Discussionsupporting

confidence: 85%

Epidemiological and Clinical Characteristics of Streptococcus pneumoniae Infections in a Tertiary Care Center in Bahrain (2010-2014)

AlSalaman

Alshehabi

Salah

et al. 2017

int. arab. j antimicrob. agents

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“…The presence of pneumococcal carriage and IPD is multifactorial. The presence of an underlying chronic illness is a risk factor, whereas breastfeeding has protective effect against IPD ( Chen et al, 2009 ; Haddad et al, 2008 ; Lee et al, 2003 ; Levine et al, 1999 ). Race and group child care attendance also play a role in IPD ( Pilishvili et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Retrospective study of prognostic factors in pediatric invasive pneumococcal disease

Chiu

Chi

Peng

et al. 2017

PeerJ

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Streptococcus pneumoniae remains the leading causative pathogen in pediatric pneumonia and bacteremia throughout the world. The invasive pneumococcal disease (IPD) is known as isolation of S. pneumoniae from a normally sterile site (e.g., blood, cerebrospinal fluid, synovial fluid, pericardial fluid, pleural fluid, or peritoneal fluid). The aim of this study is to survey the clinical manifestations and laboratory results of IPD and identify the prognostic factors of mortality. From January 2001 to December 2006, a retrospective review of chart was performed in a teaching hospital in Taipei. The hospitalized pediatric patients with the diagnosis of pneumonia, arthritis, infectious endocarditis, meningitis or sepsis were recruited. Among them, 50 patients were pneumococcal infections proved by positive culture results or antigen tests. Clinical manifestations, laboratory data and hospitalization courses were analyzed. The median age was 3.5-year-old and there were 30 male patients (60%). Eight patients (16%) had underlying disease such as leukemia or congenital heart disease. Hemolytic uremic syndrome (HUS) was observed in ten patients and extracorporeal membrane oxygenation (ECMO) was performed in three patients. Leukocytosis, elevated C-reactive protein and AST level were noted in most of the patients. The overall mortality rate was 10%. We found that leukopenia, thrombocytopenia and high CRP level were significant predictors for mortality. In conclusion, S. pneumoniae remains an important health threat worldwide and IPD is life-threatening with high mortality rate. We found leukopenia, thrombocytopenia, and high CRP levels to be associated with mortality in pediatric IPD, and these factors are worthy of special attention at admission. Although we failed to identify a statistically significant prognostic factor in multivariate analysis due to relatively small sample size, we suggest an aggressive antibiotic treatment in patients with these factors at admission. Further large-scale studies are warranted.

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“…This finding was consistent with case-fatality rates of invasive pneumococcal diseases ranging between 6% and 36% that have been described by other investigators during the past 5 decades. 2,4,[6][7][8][9][10]15,24,[28][29][30][31][32][33] The multivariate analysis revealed 3 independent risk factors that adversely affected survival, namely, coronary artery disease, neutropenia, and age 65 years or older. An important finding in our study was a significant reduction in the case-fatality rate, from 33% during the first half of the study period to 17% during the second half.…”

Section: Study Periodmentioning

confidence: 99%

Changes in the Epidemiology of Pneumococcal Bacteremia in a Swiss University Hospital During a 15-Year Period, 1986-2000

Trampuž

Widmer

Flückiger

et al. 2004

Mayo Clinic Proceedings

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Invasive pneumococcal infections: a clinical and microbiological analysis of 53 patients in Taiwan

Abstract: We suggest that vaccines be administered for young children and the elderly with major underlying diseases to prevent ISPI.

Cited by 13 publications

References 16 publications

Epidemiological and Clinical Characteristics of Streptococcus pneumoniae Infections in a Tertiary Care Center in Bahrain (2010-2014)

Epidemiological and Clinical Characteristics of Streptococcus pneumoniae Infections in a Tertiary Care Center in Bahrain (2010-2014)

Retrospective study of prognostic factors in pediatric invasive pneumococcal disease

Changes in the Epidemiology of Pneumococcal Bacteremia in a Swiss University Hospital During a 15-Year Period, 1986-2000

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