SummarySurgical treatments for acromegaly both by transnasal transsphenoidal cryogenic abla tion and by transsphenoidal microsurgical dissection were carried out in two different series and the postoperative follow-up results of HGH level and other pituitary hormones of both groups were compared and discussed for the first time. There were no significant differences in postoperative changes of pituitary functions between each operative method, whereas as for long-term satisfactory lowering of HGH level, i.e. radical cure of acromegaly, the microsurgical treatment was concluded as more reliable than cryogenic ablation of pituitary adenomas.