Invasive papillary carcinoma of the male breast

Abstract

Intracystic papillary carcinoma of the male breast is a very rare disease with only a few cases reported in the literature. A case is described and the additional value of MRI is discussed. To our knowledge, this is the first report regarding the MRI findings of an intracystic papillary carcinoma of the male breast.

Intracystic invasive papillary carcinoma of the male breast with analyses of loss of heterozygosity on chromosome 16q

“…Ultrasound-guided core needle biopsy is therefore the most valuable method for a correct preoperative diagnosis. Excisional biopsy is sometimes needed to confirm the diagnosis, because invasive cases have been reported previously [6][7][8].…”

Rare breast neoplasms: is there any peculiar feature on magnetic resonance mammography?

“…Whereas much is known about the MRM appearance of the most frequently encountered histological breast cancer subtypes, ductal and lobular invasive carcinomas [21], much less is known about MRM appearance of rare histological types [22][23][24][25][26]. On the other hand, rare tumours constitute a remarkable proportion of breast neoplasms and can be found rather frequently in some groups of women who might take particular advantage of MRM, namely, carriers of BRCA 1 germline mutations (medullary carcinoma) [27], patients with nipple discharge (papillary carcinoma) [28,29] and women with Gardner's disease (desmoid tumour) [30].…”

“…Sebbene al momento attuale siano già noti molti aspetti relativi alla semeiotica RMM delle neoplasie mammarie più frequenti -carcinoma duttale e lobulare infiltrante [21] sono molto meno conosciute le caratteristiche delle neoplasie maligne rare della mammella [22][23][24][25][26]. D'altra parte, queste rappresentano una quota non trascurabile dei tumori mammari e, in particolare, possono presentarsi con frequenza relativamente elevata proprio in alcuni sottogruppi di pazienti che si giovano particolarmente della RMM, ad esempio giovani donne portatrici di mutazioni del gene BRCA 1 (carcinoma midollare) [27], donne con secrezione dal capezzolo (carcinoma papillare) [28,29] e pazienti affette da sindrome di Gardner (tumore desmoide) [30].…”

Papillary carcinoma of the male breast: Report of a case

“…26 Axillary node metastasis can occur in up to 14% of the cases; therefore, an axillary staging procedure or clearance is recommended by most authors. [26][27][28] Others argue that IPC should be generally regarded as an in situ disease, therefore axillary surgery is not recommended by these authors. 2,6 A modifi ed radical mastectomy was selected in the current case, based on the nipple discharge cytology, the highly suspicious mammographic appearance, and gross lymphadenopathy.…”