Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants

Merk, Timon; Köhler, Richard; Peterson, Victoria; Lyra, Laura; Vanhoecke, Jonathan; Chikermane, Meera; Binns, Thomas; Li, Ningfei; Walton, Ashley; Bush, Alan; Sisterson, Nathan; Busch, Johannes; Lofredi, Roxanne; Habets, Jeroen; Huebl, Julius; Zhu, Guanyu; Yin, Zixiao; Zhao, Baotian; Merkl, Angela; Bajbouj, Malek; Krause, Patricia; Faust, Katharina; Schneider, Gerd-Helge; Horn, Andreas; Zhang, Jianguo; Kühn, Andrea; Richardson, R. Mark; Neumann, Wolf-Julian

doi:10.21203/rs.3.rs-3212709/v1

Cited by 4 publications

(3 citation statements)

References 67 publications

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“…We processed data in a real-time compatible fashion using the open-source toolbox py_neuromodulation. 19 In 100 ms steps, data batches of the previous 500 ms were processed. ECoG and STN-LFP signals were referenced in a bipolar setup and notch-filtered to remove line noise (50, 100 and 150 Hz).…”

Section: Methodsmentioning

confidence: 99%

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Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease

Köhler,

Binns,

Merk

et al. 2023

Preprint

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The ability to initiate volitional action is fundamental to human behavior. Loss of dopaminergic neurons in Parkinson’s disease (PD) is associated with impaired action initiation, also termed akinesia. Dopamine and subthalamic deep brain stimulation (DBS) can alleviate akinesia, but the underlying mechanisms are unknown. We recorded invasive neural activity from both sensorimotor cortex and subthalamic nucleus (STN) in 25 PD patients performing self-initiated movements. Readiness potentials and brain signal decoding revealed long latencies between the neural representation of motor intention and execution. Dopamine and STN-DBS shortened these latencies, while shifting directional cortico-subthalamic oscillatory coupling from antikinetic beta (13-35 Hz) to prokinetic theta (4-10 Hz) rhythms. Our study highlights a key role for dopamine and basal ganglia in the evolution of preparatory brain signals and orchestration of neural dynamics in encoding of volitional action.

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Section: Methodsmentioning

confidence: 99%

“…We processed data in a real-time compatible fashion using the open-source toolbox py_neuromodulation 54 . In 100 ms steps, data batches of the previous 500 ms were processed.…”

Section: Classification Of Motor Intentionmentioning

confidence: 99%

Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease

Köhler,

Binns,

Merk

et al. 2023

Preprint

Self Cite

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show abstract

“…from invasive brain signals (Köhler et al, 2023) could close the loop and act as a dopamine and basal ganglia neuroprosthetic (see Figure 4b). Here, machine learning methods, such as contrastive learning (Schneider et al, 2023), could be used to decode movement intention or presence from cortical activity and trigger stimulation (Merk et al, 2022(Merk et al, , 2023.…”

Section: Neural Reinforcement As a Target For Adaptive Deep Brain Sti...mentioning

confidence: 99%

Dopaminergic reinforcement in the motor system: Implications for Parkinson's disease and deep brain stimulation

Cavallo,

Neumann

2024

Eur J of Neuroscience

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Millions of people suffer from dopamine‐related disorders spanning disturbances in movement, cognition and emotion. These changes are often attributed to changes in striatal dopamine function. Thus, understanding how dopamine signalling in the striatum and basal ganglia shapes human behaviour is fundamental to advancing the treatment of affected patients. Dopaminergic neurons innervate large‐scale brain networks, and accordingly, many different roles for dopamine signals have been proposed, such as invigoration of movement and tracking of reward contingencies. The canonical circuit architecture of cortico‐striatal loops sparks the question, of whether dopamine signals in the basal ganglia serve an overarching computational principle. Such a holistic understanding of dopamine functioning could provide new insights into symptom generation in psychiatry to neurology. Here, we review the perspective that dopamine could bidirectionally control neural population dynamics, increasing or decreasing their strength and likelihood to reoccur in the future, a process previously termed neural reinforcement. We outline how the basal ganglia pathways could drive strengthening and weakening of circuit dynamics and discuss the implication of this hypothesis on the understanding of motor signs of Parkinson's disease (PD), the most frequent dopaminergic disorder. We propose that loss of dopamine in PD may lead to a pathological brain state where repetition of neural activity leads to weakening and instability, possibly explanatory for the fact that movement in PD deteriorates with repetition. Finally, we speculate on how therapeutic interventions such as deep brain stimulation may be able to reinstate reinforcement signals and thereby improve treatment strategies for PD in the future.

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Cortical brain signals improve decoding of movement and tremor for clinical brain computer interfaces

Neumann

2024

Clinical Neurophysiology

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Invasive neurophysiology and whole brain connectomics for neural decoding in patients with brain implants

Cited by 4 publications

References 67 publications

Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease

Dopamine and DBS accelerate the neural dynamics of volitional action in Parkinson’s disease

Dopaminergic reinforcement in the motor system: Implications for Parkinson's disease and deep brain stimulation

Cortical brain signals improve decoding of movement and tremor for clinical brain computer interfaces

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