Invasive mole in a perimenopausal woman with lung and vaginal metastases: A case report

Leocadio, Cristina Martinez; Villayzán, José García; López, Jesús García; Idrovo, Franklin; Arranz, Javier Plaza; González, Manuel Albi

doi:10.1002/ccr3.2386

Cited by 8 publications

(6 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although spontaneous pregnancy is rare in perimenopausal women, extremes of maternal age are an established risk factor for complete molar pregnancies. Abnormal gametogenesis and fertilization of the ovum is the probable mechanism of disease development [3][4][5]. This case demonstrates the importance of considering GTN in cases of abnormal uterine bleeding in perimenopausal women.…”

Section: Discussionmentioning

confidence: 76%

See 1 more Smart Citation

A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case

Tomé¹,

Palma²,

Antunes³

et al. 2023

Cureus

View full text Add to dashboard Cite

Gestational trophoblastic neoplasia (GTN) represents a heterogeneous group of pregnancy-related tumors that usually develop from the malignant transformation of trophoblastic tissue after molar evacuation. The first presentation as an invasive mole is particularly rare. GTN is considered the most curable gynecological malignancy as most cases are treated successfully with chemotherapy agents. Although extremes of reproductive age are an established risk factor for complete moles, GTN is extremely rare in perimenopausal women. GTN should be considered in the differential diagnosis of patients with abnormal uterine bleeding. Delays in the diagnosis and treatment can worsen the prognosis of patients with GTN.Here, we describe the case of a 54-year-old woman who presented to the emergency department with abdominal pain and heavy vaginal bleeding. She reported pregnancy-related symptoms that had developed over two months but was apprehensive to search for medical care. The final diagnosis was an invasive mole that had a catastrophic clinical course. Arterial embolization should be considered in patients with uncontrollable vaginal bleeding and hemodynamic instability.

show abstract

Section: Discussionmentioning

confidence: 76%

“…The clinical presentation of invasive mole includes nonspecific symptoms such as abnormal uterine bleeding, enlarged uterus, pelvic pain, and effects associated with stimulation by human chorionic gonadotropin (hCG) [ 3 , 4 ]. Uterine perforation, hemoperitoneum, or profuse bleeding are extremely rare [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case

Tomé¹,

Palma²,

Antunes³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…These neoplasms are preceded by hydatidiform moles in approximately 95% of cases. Other risk factors include pregnancies at extreme reproductive age, history of spontaneous abortions, vitamin A deficiency, oral contraceptives, and paternal and environmental factors [ 4 ]. As our patient had no history of molar pregnancies or spontaneous abortions, the initial diagnosis of an invasive mole represented a rare entity.…”

Section: Discussionmentioning

confidence: 99%

“…The second case was reported by Taskin et al in 2006 [ 6 ]. A case was subsequently reported in 2015, three cases were reported in 2016 [ 7 – 10 ], and the seventh case was reported in 2019 by Martinez Leocardio et al [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

An invasive mole with pulmonary metastases in a 55-year-old postmenopausal Syrian woman: a case report and review of the literature

et al. 2021

View full text Add to dashboard Cite

Background Invasive mole is a subtype of gestational trophoblastic neoplasms (GTNs) that usually develops from the malignant transformation of trophoblastic tissue after molar evacuation. Invasive moles mostly occur in women of reproductive age, while they are extremely rare in postmenopausal women. Case presentation We present the case of a 55-year-old postmenopausal Syrian woman who was admitted to the emergency department at our hospital due to massive vaginal bleeding for 10 days accompanied by constant abdominal pain with diarrhea and vomiting. Following clinical, laboratory and radiological examination, total hysterectomy with bilateral salpingo-oophorectomy was performed. Histologic examination of the resected specimens revealed the diagnosis of an invasive mole with pulmonary metastases that were diagnosed by chest computed tomography (CT). Following surgical resection, the patient was scheduled for combination chemotherapy. However, 2 weeks later the patient was readmitted to the emergency department due to severe hemoptysis and dyspnea, and later that day the patient died in spite of resuscitation efforts. Conclusion Although invasive moles in postmenopausal women have been reported previously, we believe our case is the first reported from Syria. Our case highlights the difficulties in diagnosing invasive moles in the absence of significant history of gestational trophoblastic diseases. The present study further reviews the diagnostic methods, histological characteristics and treatment recommendations.

show abstract

“…Việc siêu âm đầu dò qua đường âm đạo cũng giúp chẩn đoán các trường hợp chửa trứng. Chụp cắt lớp vi tính và chụp cộng hưởng từ (MRI) giúp cho việc phân giai đoạn và phát hiện các tổn thương di căn, ví dụ như di căn phổi ở một số trường hợp 2,4 . Trường hợp bệnh nhân chúng tôi báo cáo có kết quả siêu âm phù hợp.…”

Section: Kết Luậnunclassified

Báo Cáo Nhân Một Trường Hợp Chửa Trứng Xâm Nhập Ở Phụ Nữ Tiền Mãn Kinh Và Hồi Cứu Y Văn

Thu¹,

Phượng²,

Yến³

2022

VMJ

View full text Add to dashboard Cite

Chửa trứng xâm nhập là bệnh phổ biến trong số các bệnh lý nguyên bào nuôi thai kỳ. Tần suất gặp chửa trứng xâm nhập đứng hàng thứ 2 sau chửa trứng không xâm nhập. Chửa trứng xâm nhập phá hủy tại tử cung, xâm nhập mạch máu và có thể di căn xa. Chửa trứng xâm nhập thường gặp ở lứa tuổi sinh đẻ, hiếm gặp ở tuổi tiền mãn kinh và mãn kinh. Vì vậy, chúng tôi báo cáo ca bệnh được chẩn đoán chửa trứng xâm nhập ở tuổi 55 là trường hợp hiếm gặp. Ca bệnh: Nữ, tuổi tiền mãn kinh, rong huyết kéo dài, không có tiền sử chửa trứng hay xảy thai bất thường. ßHCG cao hơn bình thường. Siêu âm và giải phẫu bệnh sau mổ cho kết quả: chửa trứng xâm nhập tử cung, mạch máu. Giai đoạn FIGO I với số điểm theo FIGO 2000 là 10 điểm, thuộc nhóm có yếu tố nguy cơ cao. Sau điều trị phẫu thuật và hóa trị liệu với Methotrexat x 4 chu kỳ, bệnh nhân đáp ứng tốt với điều trị hóa chất. Kết luận: Chửa chứng xâm nhập hiếm gặp ở bệnh nhân tiền mãn kinh. Chẩn đoán dựa vào siêu âm, định lượng ßHCG và kết quả mô bệnh học. Điều trị chủ yếu là phẫu thuật và hóa trị liệu. Bệnh đáp ứng đặc biệt tốt với hóa chất. Bệnh tiên lượng tốt vì đáp ứng với hóa chất điều trị.

show abstract

Invasive mole in a perimenopausal woman with lung and vaginal metastases: A case report

Cited by 8 publications

References 13 publications

A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case

A Metastatic Invasive Mole in a Perimenopausal Woman: A Rare Case

An invasive mole with pulmonary metastases in a 55-year-old postmenopausal Syrian woman: a case report and review of the literature

Báo Cáo Nhân Một Trường Hợp Chửa Trứng Xâm Nhập Ở Phụ Nữ Tiền Mãn Kinh Và Hồi Cứu Y Văn

Contact Info

Product

Resources

About