Invasive micropapillary carcinomas arising 42 years after augmentation mammoplasty: A case report and literature review

Tanaka, Yūko; Morishima, Isamu; Kikuchi, Kazunori

doi:10.1186/1477-7819-6-33

Cited by 17 publications

(13 citation statements)

References 24 publications

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“…Histologically, inflammatory granulomas and foreign body giant cells were observed with stromal invasion of invasive ductal carcinoma. Various histological types of cancer have been reported after liquid silicone injection in the previous literature [ 6 , 12 , 15 , 17 , 18 , 20 - 23 ]. Interestingly, there are two cases of squamous cell carcinoma following liquid silicone injection [ 15 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Breast carcinoma originating from a silicone granuloma: a case report

et al. 2015

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Breast carcinoma rarely occurs in cases of foreign body granulomas following liquid silicone injection. Although the Food and Drug Administration (FDA) banned the use of all silicone injection products in 1992, liquid silicone injection for breast augmentation continues to be performed illegally. We herein report a case of breast carcinoma following liquid silicone injection in a 67-year-old female.A total of 45 years after liquid silicone injection, the patient had felt a breast mass in the right breast. Mammography showed a smooth mass that retracted the right nipple. Due to the presence of a marked acoustic shadow caused by the granulomas, evaluating the mass on ultrasonography was difficult. However, magnetic resonance imaging (MRI) showed a lobulated mass under the right nipple. The mass exhibited low signal intensity (SI) on T1-weighted images and intermingled high and low SI on T2-weighted images. Heterogeneous early enhancement with central low intensity was noted on dynamic contrast-enhanced MRI. Several oval-shaped low SI structures in the adipose tissue and disruption of the pectoralis major muscle were also observed. We diagnosed the patient with invasive ductal carcinoma based on a stereotactic-guided Mammotome® (a vacuum-assisted biopsy system manufactured by DEVICOR MEDICAL JAPAN, Tokyo, Japan) biopsy and subsequently performed mastectomy and axillary lymph node dissection (with a positive result for the sentinel node biopsy). Histologically, invasive ductal carcinoma was observed in the silicone granuloma.The development of foreign body granulomas following breast augmentation usually makes it difficult to detect breast cancer; thus, various devices are required to confirm the histological diagnosis of breast lesions. The stereotactic-guided Mammotome® biopsy system may be an effective device for diagnosing breast cancer developing in the augmented breast.

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Section: Discussionmentioning

confidence: 99%

Breast carcinoma originating from a silicone granuloma: a case report

et al. 2015

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“…The National Institutes of Health found no associations between breast implants and cancer, autoimmune disorder, neurologic disorder, or other systemic diseases. 63 Moreover, the risk of breast cancer is not higher for silicone implants compared with saline-filled implants. 63,64 However, there have been a few reports of carcinoma which seemed to arise from the breast implant capsule.…”

Section: Carcinoma In the Capsule Or Adjacent To The Capsulementioning

confidence: 99%

Capsular Contracture in Breast Augmentation: Medical Management and Indications for Capsulectomy

Florin

Haiavy

2018

Am J Cosmet Surg

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This article reviews the literature on the etiology and management of capsular contracture, focusing on indications for capsulectomy along with explantation of breast implants. This article outlines the clinical factors which should be considered when managing capsular contracture. This article offers the most comprehensive review to date of surgical and nonsurgical management of capsular contracture. The goal of treatment is to prevent recurrence of capsular contracture, minimize risk to the patient, and obtain esthetic results. Capsulectomy is indicated in the majority of cases when breast implants are being removed or replaced in the setting of contracture. However, the surgeon must consider the risks and benefits of capsulectomy.

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“…Some authors report in singular cases that cancers in augmented women usually are more advanced at the time of detection (13,14), whereas others have reported no significant difference in tumor size or stage at the time of diagnosis in augmented women compared to non-augmented women.…”

Section: Breast Cancer Characteristics Between Women Treated With Primentioning

confidence: 99%

“…Tanaka et al reported in 2008 a case of three invasive micropapillary carcinomas in a 64-year-old woman who underwent breast augmentation 42 years before (14). The multiple tumors were located next to the siliconomas suggesting a possible relationship between siliconomas and the onset of carcinomas.…”

Section: Breast Cancer Characteristics Between Women Treated With Primentioning

confidence: 99%

“…Incidence rates vary from 19.3 per 100,000 women in Eastern Africa to 89.7 per 100,000 women in Western Europe, and are high (greater than 80 per 100,000) in developed regions of the world (except Japan) and low (less than 40 per 100,000) in most of the developing regions. The range of mortality rates is much less (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) per 100,000) because of the more favorable survival of breast cancer in (high-incidence) developed regions. As a result, breast cancer ranks as the fifth cause of death from cancer overall (458,000 deaths), but it is still the most frequent cause of cancer death in women in both developing (269,000 deaths, 12.7% of total) and developed regions, where the estimated 189,000 deaths is almost equal to the estimated number of deaths from lung cancer (188,000 deaths) (1).…”

Section: Introductionmentioning

confidence: 99%

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Breast cancer risk in women treated with augmentation mammoplasty (Review)

et al. 2012

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Abstract. Surgical implantation of breast prostheses has become increasingly popular while the incidence of breast cancer is increasing each year. There has been no definitive consensus regarding the casual relationship between augmentation mammoplasty and breast cancer incidence, detection, treatment, mortality and survival. This review summarizes the published evidence, including epidemiological studies and case reports. All studies examined state that there is no breast cancer risk in prior augmented women. Moreover, there is also no significant difference in frequency, stage or mean tumor size between augmented and non-augmented women.

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Invasive micropapillary carcinomas arising 42 years after augmentation mammoplasty: A case report and literature review

Cited by 17 publications

References 24 publications

Breast carcinoma originating from a silicone granuloma: a case report

Breast carcinoma originating from a silicone granuloma: a case report

Capsular Contracture in Breast Augmentation: Medical Management and Indications for Capsulectomy

Breast cancer risk in women treated with augmentation mammoplasty (Review)

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