Invasive Micropapillary Carcinoma of the Breast

Badyal, Rama Kumari; Bal, Amanjit; Das, Ashim; Singh, Gurpreet

doi:10.1097/pai.0000000000000167

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…Furthermore, the micropapillary pattern is formed by small clusters of tumor cells without vessels and stromal cells in the middle of a tumor cluster 25. It has been reported to appear in cancers of the breast, bladder, lung, pancreas, ovary, urothelial tract, and stomach 26-29 and is associated with tumor differentiation, lymph node and distant metastasis, and lymphovascular tumor emboli 7, 17. PGCCs appear in most of micropapillary carcinoma patterns and tumor buds 7, 12, 30.…”

Section: Discussionmentioning

confidence: 99%

CK7 expression associates with the location, differentiation, lymph node metastasis, and the Dukes' stage of primary colorectal cancers

Fei

Cao³

et al. 2019

J. Cancer

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Purpose : Most colorectal cancers (CRCs) show positive immunohistochemical (IHC) staining for CK20 and negative staining for CK7. However, in clinical settings, some CRCs show positive IHC staining for CK7, and the clinicopathological significance of this needs to be studied. This study investigated the clinicopathological significance of CK7 positivity in CRCs. Materials and Methods : A total of 178 patients with CRC were used to study the clinicopathological significance of CK7 positivity. Western blotting and immunocytochemical (ICC) staining were used to compare the expression levels of CK7 before and after CoCl 2 treatment. Results : CK7 expression was associated with the location, differentiation, lymph node metastasis, and the Dukes' stage of CRCs. CK7 positive cells were mainly distributed at the edge of cancer nests, at the invasion front, as single stromal polyploid giant cancer cells (PGCCs), in tumor buds, in intravascular tumor emboli, and in a micropapillary pattern. Results of ICC staining showed that CK7 expression was almost negative in LoVo and HCT116 before CoCl 2 treatment. After CoCl 2 treatment, the PGCCs and their daughter cells of LoVo and HCT116 yielded positive results in CK7 ICC staining. Results of western blotting also confirmed that there was higher CK7 expression in LoVo and HCT116 after CoCl 2 treatment than in the control. Conclusion : CRC cells expressing CK7 may have strong invasive and metastatic abilities. Some metastasis-related morphological characteristics in CRCs including the invasion front, micropapillary pattern, tumor emboli, and single stromal PGCCs associated with CK7 positive expression.

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Section: Discussionmentioning

confidence: 99%

CK7 expression associates with the location, differentiation, lymph node metastasis, and the Dukes' stage of primary colorectal cancers

Fei

Cao³

et al. 2019

J. Cancer

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“…Our data are in agreement with previous findings, demonstrating that cancer cells with epithelial phenotype display reduced migration and invasion capacity in vitro , but exhibit superior capacity to colonize secondary sites in vivo , when compared to mesenchymal-like cancer cells [ 42 , 48 – 55 ]. Indeed, overexpression of different epithelial markers was observed in the metastatic sites of ovarian [ 56 ], breast [ 57 – 60 ], colorectal [ 61 , 62 ], prostate [ 63 , 64 ], lung [ 65 , 66 ], and gastric cancer [ 67 ], which is a strong indication that the cancer cells in the primary tumor and their metastatic lesions share a similar epithelial nature. Interestingly, the “Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency” canonical pathway was among the pathways, significantly upregulated upon LY75 knockdown in SKOV3 cells (see Supplemental Figure 6A ), which supports literature data underlying the superior capability of cancer cells bearing the epithelial phenotype to maintain ES cells-like features that are essential for self-renewal, pluripotency, and enhanced invasiveness [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells

et al. 2016

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The molecular basis of epithelial ovarian cancer (EOC) dissemination is still poorly understood. Previously, we identified the mannose receptor LY75 gene as hypomethylated in high-grade (HG) serous EOC tumors, compared to normal ovarian tissues. LY75 represents endocytic receptor expressed on dendritic cells and so far, has been primarily studied for its role in antigen processing and presentation. Here we demonstrate that LY75 is overexpressed in advanced EOC and that LY75 suppression induces mesenchymal-to-epithelial transition (MET) in EOC cell lines with mesenchymal morphology (SKOV3 and TOV112), accompanied by reduction of their migratory and invasive capacity in vitro and enhanced tumor cell colonization and metastatic growth in vivo. LY75 knockdown in SKOV3 cells also resulted in predominant upregulation of functional pathways implicated in cell proliferation and metabolism, while pathways associated with cell signaling and adhesion, complement activation and immune response were mostly suppressed. Moreover, LY75 suppression had an opposite effect on EOC cell lines with epithelial phenotype (A2780s and OV2008), by directing epithelial-to-mesenchymal transition (EMT) associated with reduced capacity for in vivo EOC cell colonization, as similar/identical signaling pathways were reversely regulated, when compared to mesenchymal LY75 knockdown EOC cells.To our knowledge, this is the first report of a gene displaying such pleiotropic effects in sustaining the cellular phenotype of EOC cells and points to novel functions of this receptor in modulating EOC dissemination. Our data also support previous findings regarding the superior capacity of epithelial cancer cells in metastatic colonization of distant sites, compared to cancer cells with mesenchymal-like morphology.

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“…Micropapillary pattern has been detected in about 20% of CRCs, a phenomenon analogous to the more familiar one seen in some carcinomas of breast, bladder, lung, pancreas, ovary, urothelial tract, and stomach [85–88]. Micropapillary pattern in carcinomas is associated with a greater frequency of lymphovascular invasion and lymph node metastases and poor prognosis [89].…”

Section: Tumor Budding Micropapillary Pattern and Pgccs In Crcsmentioning

confidence: 99%

Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects

Zhang¹,

Zhang²,

Yang³

et al. 2016

Stem Cells International

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We previously reported that polyploid giant cancer cells (PGCGs) induced by CoCl2 could form through endoreduplication or cell fusion. A single PGCC formed tumors in immunodeficient mice. PGCCs are also the key contributors to the cellular atypia and associate with the malignant grade of tumors. PGCCs have the properties of cancer stem cells and produce daughter cells via asymmetric cell division. Compared with diploid cancer cells, these daughter cells express less epithelial markers and acquire mesenchymal phenotype with importance in cancer development and progression. Tumor budding is generally recognized to correlate with a high recurrence rate, lymph node metastasis, chemoresistance, and poor prognosis of colorectal cancers (CRCs) and is a good indicator to predict the metastasis and aggressiveness in CRCs. Micropapillary pattern is a special morphologic pattern and also associates with tumor metastasis and poor prognosis. There are similar morphologic features and molecular phenotypes among tumor budding, micropapillary carcinoma pattern, and PGCCs with their budding daughter cells and all of them show strong ability of tumor invasion and migration. In this review, we discuss the cancer stem cell properties of PGCCs, the molecular mechanisms of their regulation, and the relationships with tumor budding and micropapillary pattern in CRCs.

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Invasive Micropapillary Carcinoma of the Breast

Cited by 15 publications

References 25 publications

CK7 expression associates with the location, differentiation, lymph node metastasis, and the Dukes' stage of primary colorectal cancers

CK7 expression associates with the location, differentiation, lymph node metastasis, and the Dukes' stage of primary colorectal cancers

The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells

Tumor Budding, Micropapillary Pattern, and Polyploidy Giant Cancer Cells in Colorectal Cancer: Current Status and Future Prospects

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