Invasive meningococcal disease in Malaysia, Philippines, Thailand, and Vietnam: An Asia-Pacific expert group perspective on current epidemiology and vaccination policies

Thisyakorn, Usa; Carlos, Josefina; Chotpitayasunondh, Tawee; Dien, Tran Minh; Gonzales, Maria; Nguyen, Thi Lien Huong; Ismail, Zulkifli; Nordin, Musa Mohd; Ong-Lim, Anna Lisa; Tantawichien, Terapong; Terumalay, Sangita Dharshini; Thiem, Vu Dinh; Cintra, Otávio; Oladehin, Olakunle

doi:10.1080/21645515.2022.2110759

Cited by 3 publications

(5 citation statements)

References 19 publications

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“…The two vaccines available in Vietnam are the meningococcal serogroup A, C, W and Y vaccine (MenACWY) and the BC meningococcal polysaccharide vaccines. 50 BC vaccine is indicated for ages 6 months to 45 years of age and is an outer membrane vesicle (OMV) vaccine that cannot offer full protection. 51…”

Section: Discussionmentioning

confidence: 99%

Review of the epidemiology, diagnosis and management of invasive meningococcal disease in Vietnam

Nguyen

Hưng

Mathur³

et al. 2023

Human Vaccines & Immunotherapeutics

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Invasive meningococcal disease (IMD), caused by Neisseria meningitidis , is life-threatening with a high case fatality rate (CFR) and severe sequelae. We compiled and critically discussed the evidence on IMD epidemiology, antibiotic resistance and disease management in Vietnam, focusing on children. PubMed, Embase and gray literature searches for English, Vietnamese and French publications, with no date restrictions, retrieved 11 eligible studies. IMD incidence rate (/100,000 population) was 7.4 [95% confidence interval 3.6–15.3] in children under 5 years of age; driven by high rates in infants (e.g. 29.1 [8.0–106.0] in 7–11 month-olds). Serogroup B IMD was predominant. Neisseria meningitidis strains may have developed resistance to streptomycin, sulfonamides, ciprofloxacin, and possibly ceftriaxone. There was a lack of current data on diagnosis and treatment of IMD, which remain challenging. Healthcare professionals should be trained to rapidly recognize and treat IMD. Preventive measures, such as routine vaccination, could help address the medical need.

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Section: Discussionmentioning

confidence: 99%

Review of the epidemiology, diagnosis and management of invasive meningococcal disease in Vietnam

Nguyen

Hưng

Mathur³

et al. 2023

Human Vaccines & Immunotherapeutics

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“… 42 In the Philippines, around 100 IMD cases are typically reported annually, with 50% occurring in those <5 years of age; most cases are MenA, although MenB is also observed. 58 , 60 In Egypt, a high proportion of confirmed IMD cases identified between 1998 and 2004 were MenB (51%), 61 although more recent data are lacking. 62 , 63 …”

Section: Imd Epidemiology In Gcc Countriesmentioning

confidence: 99%

Meningococcal disease within the Gulf Cooperation Council Countries

Awaidy

Ozudogru

Badur³

2023

Human Vaccines & Immunotherapeutics

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This review reports on the recent epidemiology of invasive meningococcal disease (IMD) within the Gulf Cooperation Council (GCC) Countries (focusing from 2012 onwards), the existing immunization strategies and the potential for IMD resurgence. MenACWY vaccination is now established in infant or adolescent immunization programs in Saudi Arabia, Bahrain, Kuwait, and the United Arab Emirates. At present, GCC Countries do not include MenB immunization. National health surveillance reports indicate a total of 156 IMD cases reported across the GCC Countries between 2012 and 2021; between 30% and 80% of cases were reported in individuals aged ≥15 years. Lack of serogroup data hinders the assessment of vaccine impact and decision-making on additional vaccine introductions (e.g. MenB immunization). Hajj/Umrah pilgrimage and the increasing number of large-scale commercial and social events held in the GCC Countries pose a potential risk for future IMD outbreaks. Immunization policies for such events could be strengthened.

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“…For Asian countries in the Asia–Pacific region, IMD incidence ranged from 0.02 (the Philippines) to 0.2 (Singapore) cases per 100,000 population, with higher incidence rates reported in some subpopulations, e.g., in infants, children, and adolescents [ 9 ]. In the Philippines, surveillance data from 2019 reported that around half of all cases occurred in children < 5 years, and around 25% in infants < 1 year [ 10 ]. Surveillance data in Thailand reported IMD incidence rates of < 0.10 from 2010 to 2019, with the highest incidence in children < 5 years [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the Philippines, surveillance data from 2019 reported that around half of all cases occurred in children < 5 years, and around 25% in infants < 1 year [ 10 ]. Surveillance data in Thailand reported IMD incidence rates of < 0.10 from 2010 to 2019, with the highest incidence in children < 5 years [ 10 ]. Case fatality rates were considerably higher in some countries e.g., around 40–50% in Thailand and the Philippines compared with 10–16% in China and Japan [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

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4CMenB Vaccination to Prevent Meningococcal B Disease in Vietnam: Expert Review and Opinion

Nguyen,

Thai,

Dien

et al. 2024

Infect Dis Ther

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An advisory board meeting was held with experts in Vietnam (Hanoi, August 2022), to review the evidence on invasive meningococcal disease (IMD) epidemiology, clinical management, and meningococcal vaccines to reach a consensus on recommendations for meningococcal vaccination in Vietnam. IMD is a severe disease, with the highest burden in infants and children. IMD presents as meningitis and/or meningococcemia and can progress extremely rapidly. Almost 90% of deaths in children occur within the first 24 h, and disabling sequelae (e.g., limb amputations and neurological damage) occur in up to 20% of survivors. IMD patients are often hospitalized late, due to mild and nonspecific early symptoms and misdiagnosis. Difficulties related to diagnosis and antibiotic misuse mean that the number of reported IMD cases in Vietnam is likely to be underestimated. Serogroup B IMD is predominant in many regions of the world, including Vietnam, where 82% of IMD cases were due to serogroup B (surveillance data from 2012 to 2021). Four component meningococcal B vaccine (4CMenB) is used in many countries (and is part of the pediatric National Immunization Program in 13 countries), with infant vaccination starting from two months of age, and a 2 + 1 dosing schedule. Experts recommend 4CMenB vaccination as soon as possible in Vietnam, starting from two months of age, with a 2 + 1 dosing schedule, and at least completing one dose before 6 months of age. Supplementary Information The online version contains supplementary material available at 10.1007/s40121-023-00905-y.

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Invasive meningococcal disease in Malaysia, Philippines, Thailand, and Vietnam: An Asia-Pacific expert group perspective on current epidemiology and vaccination policies

Cited by 3 publications

References 19 publications

Review of the epidemiology, diagnosis and management of invasive meningococcal disease in Vietnam

Review of the epidemiology, diagnosis and management of invasive meningococcal disease in Vietnam

Meningococcal disease within the Gulf Cooperation Council Countries

4CMenB Vaccination to Prevent Meningococcal B Disease in Vietnam: Expert Review and Opinion

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