Invasive meningococcal disease epidemiology and characterization of <i>Neisseria meningitidis</i> serogroups, sequence types, and clones; implication for use of meningococcal vaccines

Stein‐Zamir, Chen; Shoob, Hanna; Abramson, Nitza; Block, Colin; Keller, Natan; Jaffe, Joseph; Valinsky, Lea

doi:10.1080/21645515.2018.1507261

Human Vaccines & Immunotherapeutics

2018

DOI: 10.1080/21645515.2018.1507261

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Invasive meningococcal disease epidemiology and characterization of Neisseria meningitidis serogroups, sequence types, and clones; implication for use of meningococcal vaccines

Chen Stein‐Zamir

Hanna Shoob

Nitza Abramson

et al.

Abstract: Preliminary analysis based on limited number of samples suggests that the 4CMenB coverage would be about half the strains; further research is necessary. Integration of clinical, epidemiological and laboratory data is essential to support decision-making on the introduction of the novel MENB vaccines in Israel.

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Cited by 4 publications

(17 citation statements)

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“…by N. meningitidis strains that belong to six serogroups (A, B, C, W, X, and Y) (2,3). Also, strains of N. meningitidis that are associated with invasive meningococcal disease (IMD), particularly those capable of causing outbreaks and epidemics, can be classified by multilocus sequence typing (MLST) into a few clonal complexes (CCs) that are related to sequence types (STs) with no more than three of their seven MLST loci being different (https://pubmlst.org/neisseria/) (2,4).…”

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confidence: 99%

Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup BNeisseria meningitidisStrains and Their Predicted Coverage by the 4CMenB Vaccine

Tsang

Law

Paola³

et al. 2020

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The molecular epidemiology of culture-confirmed invasive meningococcal disease (IMD) in Canada from 2010 to 2014 was studied with an emphasis on serogroup B Neisseria meningitidis (MenB) isolates, including their predicted coverage by the 4CMenB vaccine. The mean annual incidence rates of culture confirmed IMD varied from 0.19/100,000 in Ontario to 0.50/100,000 in New Brunswick and 0.59/100,000 in Quebec. In both Quebec and Atlantic region, MenB was significantly more common than other serogroups, while in other provinces, both MenB and serogroup Y (MenY) were almost equally common. The majority of MenB cases (67.0%) were in those aged ≤24 years, while most MenC (75.0%) and MenY (69.6%) cases were in adults more than 24 years old. The 349 MenB isolates were grouped into 103 sequence types (STs), 90 of which belonged to 13 clonal complexes (CCs). A large number of 4CMenB antigen genes were found among the Canadian MenB, which is predicted to encode 50 factor H binding protein (fHbp) types, 40 NHBA types, and 55 PorA genotypes. Provinces and regions were found to have their own unique MenB STs. A meningococcal antigen typing system assay predicted an overall MenB coverage by 4CMenB to be 73.6%, with higher coverage predicted for the two most common STs: 100% for ST154 and 95.9% for ST269, leading to higher coverage in both the Atlantic region and Quebec. Higher coverage (81.4%) was also found for MenB recovered from persons aged 15 to 24 years, followed by strains from infants and children ≤4 years old (75.2%) and those aged 5 to 14 years (75.0%). IMPORTANCE Laboratory surveillance of invasive meningococcal disease (IMD) is important to our understanding of the evolving nature of the Neisseria meningitidis strain types causing the disease and the potential coverage of disease strains by the newly developed vaccines. This study examined the molecular epidemiology of culture-confirmed IMD cases in Canada by examining the strain types and the potential coverage of a newly licensed 4CMenB vaccine on Canadian serogroup B N. meningitidis strains. The strain types identified in different parts of Canada appeared to be unique as well as their predicted coverage by the 4CMenB vaccine. These data were compared to data obtained from previous studies done in Canada and elsewhere globally. For effective control of IMD, laboratory surveillance of this type was found to be essential and useful to understand the dynamic nature of this disease.

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confidence: 99%

Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup BNeisseria meningitidisStrains and Their Predicted Coverage by the 4CMenB Vaccine

Tsang

Law

Paola³

et al. 2020

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“…The IMD incidence rate in Israel over the past decade was 1/10 000 in the general population and 0.25/100 000 for those older than age 15 years [ 7 ]. Clinical isolates from IMD in Israel over the last 30 years establish serogroup B as the dominant disease-causing serogroup [ 7 , 25 ]. Molecular characterization of IMD-causing isolates (1998–2017) found CC32, CC41/44, CC35, CC162, and CC269 to be the most common strains [ 7 , 25 ].…”

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confidence: 99%

“…Clinical isolates from IMD in Israel over the last 30 years establish serogroup B as the dominant disease-causing serogroup [ 7 , 25 ]. Molecular characterization of IMD-causing isolates (1998–2017) found CC32, CC41/44, CC35, CC162, and CC269 to be the most common strains [ 7 , 25 ]. However, the carriage rate and serogroup distribution among carriers are largely unknown, as no carriage studies were ever conducted in Israel among the general population.…”

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confidence: 99%

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Prevalence and Characteristics of Carriage of Neisseria meningitidis Among Young Israeli Adults

Sofer-Sali

Roif-Kaminsky

Motro

et al. 2022

Open Forum Infectious Diseases

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Background no updated data currently exist regarding Neisseria meningitidis carriage and genomic epidemiology among young Israeli adults. Methods oropharyngeal swabs were collected from 1,801 military recruits at the day of recruitment during 2019. Neisseria meningitidis was detected and identified by culture and qPCR. Confirmed isolates were serotyped by qPCR and encapsulated strains underwent whole genome sequencing. Risk factors for carriage were determined by analyzing focused questionnaires using uni- and multivariate models. Genomic typing was performed by means of core genome multilocus sequence typing. Results carriage rates overall and of encapsulated strains were 20.1% and 6.7%, respectively. Genogroup B (49.2%) and Y (26.7%) were the most common encapsulated strains. Genogroups C, W and X were scarce and genogroup A was absent. The most notable clonal complexes were CC23 (n=30), CC32 (n=16) and CC44/41 (n=9). Carriage was significantly associated with smoking (OR=1.82, CI[1.43-2.33) and boarding school attendance prior to recruitment (OR=1.49, CI[1.14-1.96]). Conclusions the prevalence of meningococcal carriage among young Israeli adults is high, compared to similar studies in other developed countries. This might be due to sociocultural characteristics including smoking and boarding school attendance during and after high school. The dominant genogroups and CCs found were compatible with those implicated in invasive disease in Israel.

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“…Despite appropriate antimicrobial therapy and improvements in pediatric intensive care unit (PICU) settings, meningococcemia is still a major concern for clinicians due to its high morbidity and mortality. 1,2 In this article, we report a case of fatal meningococcemia caused by serogroup B, who had been vaccinated with 2 doses of of MenACYW-DT vaccine at the age of 9 and 13 months.…”

mentioning

confidence: 99%

Fatal Serogroup B Meningococcemia in a Child Previously Vaccinated With MenACWY-DT Vaccine

Kurugöl

Özenen

Bal

et al. 2021

Clin Pediatr (Phila)

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Invasive meningococcal disease epidemiology and characterization of Neisseria meningitidis serogroups, sequence types, and clones; implication for use of meningococcal vaccines

Cited by 4 publications

References 27 publications

Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup BNeisseria meningitidisStrains and Their Predicted Coverage by the 4CMenB Vaccine

Culture-Confirmed Invasive Meningococcal Disease in Canada, 2010 to 2014: Characterization of Serogroup BNeisseria meningitidisStrains and Their Predicted Coverage by the 4CMenB Vaccine

Prevalence and Characteristics of Carriage of Neisseria meningitidis Among Young Israeli Adults

Fatal Serogroup B Meningococcemia in a Child Previously Vaccinated With MenACWY-DT Vaccine

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