Invasive lobular carcinomas of the breast – the prognosis of histopathological subtypes

Toit, R.S. Du; Locker, A. P.; Ellis, Ian O.; Elston, C.W.; Nicholson, R. I.; Blamey, R. W.

doi:10.1038/bjc.1989.323

Cited by 101 publications

(51 citation statements)

References 9 publications

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“…The small size of the tumours in our series may have obscured such relationships; even in larger-scale studies these correlations are still controversial (Harris et al, 1985;Fisher et al, 1986;Lindley et al, 1989;Locker et al, 1989;Kurtz et al, 1990b). In cases that did recur, the tumour specimens had macroscopically positive margins more often than those in the matched control group did.…”

Section: Discussionmentioning

confidence: 69%

“…A distinctly high incidence of infiltrating lobular carcinoma in the group with a local recurrence may indicate a higher risk of local recurrence for this group. However, consensus has not been reached in the literature on this subject (Mate et al, 1986;du Toit et al, 1989;Schnitt et al, 1989;van Limbergen et al, 1990). All five of these cases of recurrent lobular carcinoma in our study showed a remarkable similarity of the histological picture.…”

Section: Discussionmentioning

confidence: 74%

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DNA ploidy of primary breast cancer and local recurrence after breast-conserving therapy

Beerman

Bonsing²,

Vijver³

et al. 1991

Br J Cancer

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Summary The value of DNA-flow cytometry and clinico-pathological prognostic factors for the prediction of local recurrences after breast-conserving therapy (BCT) were evaluated in a retrospective study. Thirty-one patients with a local recurrence were compared with 31 matched patients without a local recurrence. Morphology and DNA-indices of the local recurrences and their corresponding primary tumours were compared. Ductal carcinoma in situ was present significantly more often in the group with a primary recurring tumour, than in the matched group (P <0.001), and the same holds for lobular carcinoma (n = 5). Half of the tumours that recurred had macroscopically positive surgical margins compared to about one-fourth of the matched group. Fifty-six per cent of the DNA-aneuploid stemlines in cases with local recurrence were present in the corresponding primary tumour as well (confidence limits 45%-75%), an indication that the majority of local recurrences are true recurrences and not independently developed tumours. The lack of similarlity of DNA stemlines between some primary DNA-aneuploid tumours and their local recurrences indicates that these tumours had developed independently. The percentage of DNA-aneuploid cases in the group with local recurrence (89%) did not differ significantly from that in the matched group (70%). However, the findings suggest a selective recurrence of DNA-diploid stemlines. This might indicate increased resistance of DNAdiploid tumour cells to radiotherapy as compared with the resistance level in DNA-aneuploid cells.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 74%

DNA ploidy of primary breast cancer and local recurrence after breast-conserving therapy

Beerman

Bonsing²,

Vijver³

et al. 1991

Br J Cancer

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“…In addition, it has been reported that ILC is less responsive to chemotherapy [3,21], lacks potential benefit of HER2 targeted therapy [16,17], being typically HER2 negative, but is more often HR positive and responsive to adjuvant hormonal therapy (HT) [11,22,23]. Reported prognosis of ILC varies and has been reported to be worse [1,9,[24][25][26][27], no different [17,[28][29][30][31][32], or better [6] than that with IDC.…”

Section: Introductionmentioning

confidence: 99%

The biological and clinical characteristics of breast carcinoma with mixed ductal and lobular morphology

Rakha

Gill

El-Sayed

et al. 2008

Breast Cancer Res Treat

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“…In cases of invasive carcinomas, differentiating ILC from IDC may have prognostic implications. Some studies [38][39][40] have reported a more favorable outcome for ILC than IDC. Two large studies with long-term follow-up showed that patients with ILC have a better or similar outcome to patients with IDC initially, but a higher risk of recurrences and distant metastases, and even higher mortality rates after the first 10 years.…”

Section: The Role Of E-cadherin In the Evaluationmentioning

confidence: 99%

Diagnostic Role of Immunohistochemistry in the Evaluation of Breast Pathology Specimens

Zhao

Yang

Khan

et al. 2014

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Immunohistochemistry plays a vital role in the evaluation of breast pathology specimens. Objective.—To discuss the role of myoepithelial cell markers in the evaluation of various breast lesions. Other markers, such as E-cadherin and those used to differentiate mammary carcinoma from metastatic tumors to the breast, and markers used in the differential diagnosis of Paget disease, are also discussed. Data Sources.—Data were obtained from review of the pertinent peer-reviewed literature. Conclusions.—Myoepithelial cell markers vary in their sensitivity and specificity, and one should be aware of the potential pitfalls in interpretation. Using panels of 2 or more myoepithelial cell markers is always recommended, either singly or in cocktail forms. Although negative E-cadherin staining supports the diagnosis of lobular origin, positive staining does not rule it out. Immunohistochemistry can be helpful in differentiating Paget disease from its mimics. Although metastatic tumors to the breast are rare, a triple-negative immunophenotype and absence of an in situ component should be a “red flag” for such possibility, especially in patients with clinical history of an extramammary malignancy.

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Invasive lobular carcinomas of the breast – the prognosis of histopathological subtypes

Cited by 101 publications

References 9 publications

DNA ploidy of primary breast cancer and local recurrence after breast-conserving therapy

DNA ploidy of primary breast cancer and local recurrence after breast-conserving therapy

The biological and clinical characteristics of breast carcinoma with mixed ductal and lobular morphology

Diagnostic Role of Immunohistochemistry in the Evaluation of Breast Pathology Specimens

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