Invasive Lobular Carcinoma of the Breast: Mammographic Characteristics and Computer-aided Detection

Evans, W. Phil; Burhenne, Linda J. Warren; Laurie, Louba; O’Shaughnessy, Kathryn F.; Castellino, Ronald A.

doi:10.1148/radiol.2251011029

Cited by 111 publications

(45 citation statements)

References 16 publications

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“…Similarly, Krecke and Gisvold reported false-negative mammography rates of 57% for D4, 29% for D3 and 9% for D2 breast densities (10). ILC appearing as a mass lesion mammographically may have a spiculated appearance (28,29). In addition to an ill-defined opacity, parenchymal asymmetry and architectural distortion are the other mammographical findings of ILC (17,28,29).…”

Section: Discussionmentioning

confidence: 95%

“…ILC appearing as a mass lesion mammographically may have a spiculated appearance (28,29). In addition to an ill-defined opacity, parenchymal asymmetry and architectural distortion are the other mammographical findings of ILC (17,28,29). Additionally, ILC may be invisible on mammograms because the density of ILC tends to be relatively low, similar to that of normal breast parenchyma, which may be the result of the relative paucity of a desmoplastic response (30).…”

Section: Discussionmentioning

confidence: 99%

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Invasive lobular carcinoma of the breast: mammographic and sonographic evaluation

Albayrak¹,

Onay²,

Karatağ³

et al. 2010

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Invasive lobular carcinoma of the breast: mammographic and sonographic evaluation

Albayrak¹,

Onay²,

Karatağ³

et al. 2010

Diagn Interv Radiol

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“…This so-called 'Indian file' pattern of infiltration causes a modest disruption of the underlying anatomic structures and generates little surrounding desmoplastic stromal reaction (Dixon et al 1982). Clinical examination of patients with ILC can be complicated because of vague findings, such as thickening or induration, which are often the only clinical signs, particularly in early disease (Evans et al 2002).…”

Section: Diagnosis Of Invasive Lobular Cancermentioning

confidence: 99%

“…The sensitivity of detecting ILC has been reported to be as low as 57-76% for Mx (Le Gal et al 1992, Evans et al 2002, while false negative rates at Mx have been observed to range from 8 to 24% (Helvie et al 1993, Krecke & Gisvold 1993. In the study by Krecke & Gisvold (1993) the mammograms of patients with ILC initially classified as normal (i.e.…”

Section: Mammographymentioning

confidence: 99%

“…1.2 (0.9-1.6) 2.2 (1.4-3.5) 6 months to !5 years 1.2 (0.9-1.5) 2.1 (1.3-3.3) R5 years 1.2 (0.9-1.7) 2.5 (1. observed with other breast malignancies (Evans et al 2002). ILC is associated with a higher incidence of asymmetric density (3-25%) or architectural distortion (10-28%) and is often less radiopaque than normal fibroglandular tissue (Mendelson et al 1989, Watson 2001.…”

Section: Mammographymentioning

confidence: 99%

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Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment

Biglia¹,

Mariani²,

Sgrò³

et al. 2007

Endocr Relat Cancer

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A growing body of evidence support the association between the use of hormone replacement therapy (HRT) and a higher risk of both invasive lobular carcinoma (ILC) and invasive ductal-lobular mixed carcinoma (IDLC). Overall biological and clinical features of ILC entail a more cautious diagnostic and therapeutic approach as compared with invasive ductal carcinoma (IDC). ILCs are more frequently multifocal, multicentric and/or bilateral. Mammography and ultrasound show, therefore, significant limitations, while the higher sensitivity of magnetic resonance imaging in the detection of multifocal and/or multicentric lesions seems to improve the accuracy of preoperative staging of ILCs. Early diagnosis is even more challenging because the difficult in the localization and the sparse cellularity of lobular tumours may determine a false negative core biopsy. ILC is characterized by low proliferative activity, C-ErbB-2 negativity, bcl-2 positivity, p53 and VEGF negativity, oestrogen and progesterone positive receptors, low grade and low likelihood of lymphaticvascular invasion. However, this more favourable biological behaviour does not reflect into a better disease-free and overall survival as compared with IDC. Since lobular histology is associated with a higher risk of positive margins, mastectomy is often preferred to breast conservative surgery. Moreover, only few patients with ILC achieve a pathologic response to preoperative chemotherapy and, therefore, in most patients mastectomy can be regarded as the safer surgical treatment. The preoperative staging and the follow-up of patients with ILC are also complicated by the particular metastatic pattern of such histotype. In fact, metastases are more frequently distributed to the gastrointestinal tract, peritoneum/retroperitoneum and gynaecological organs than in IDC.

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Evaluation of breast cancer with a computer‐aided detection system by mammographic appearance and histopathology

Brem

Rapelyea

Zisman

et al. 2005

Cancer

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Cytology has been reported to have suboptimal sensitivity for detecting pancreatobiliary tract cancer in biliary tract specimens partly as a result of low specimen cellularity and obscuring noncellular components. The goal of this study was to determine if the use of a glacial acetic acid wash prior to processing would increase the cellularity and improve the quality of ThinPrep® slides when compared to standard non‐gyn ThinPrep processing. Fifty consecutive pancreatobiliary tract specimens containing 20 ml of sample/PreservCyt® were divided equally for standard non‐gyn ThinPrep (STP) and glacial acetic acid ThinPrep processing (GATP). A manual drop preparation was also performed on residual STP specimen to determine the number of cells left in the vial during STP processing. Twenty‐six (52%) specimens had more epithelial cell groupings with the GATP methodology while 19 (38%) had equivalent cellularity with both methods. The STP method produced more epithelial cell groupings in 5 (10%) of the specimens. Of the 26 specimens that had less cells with the STP method, 14 (54%) had ≥50 cell groupings on the manual drop slide processed from the residual STP specimen suggesting that many cells remain in the vial after STP processing. The GATP method was preferred in 25 (50%) of the specimens, the STP method in 5 (10%), while both methodologies provided similar findings in the remaining 20 (40%) of specimens. The data from this study suggests that the GATP method results in more cells being placed on the slide and was preferred over the STP method in a majority of specimens. Diagn. Cytopathol. 2010;38:627–632. © 2009 Wiley‐Liss, Inc.

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Invasive Lobular Carcinoma of the Breast: Mammographic Characteristics and Computer-aided Detection

Abstract: Spiculated masses and architectural distortions are the predominant appearances of invasive lobular carcinoma, and a computer-aided detection system correctly marked a high percentage of invasive lobular carcinoma lesions.

Cited by 111 publications

References 16 publications

Invasive lobular carcinoma of the breast: mammographic and sonographic evaluation

Invasive lobular carcinoma of the breast: mammographic and sonographic evaluation

Increased incidence of lobular breast cancer in women treated with hormone replacement therapy: implications for diagnosis, surgical and medical treatment

Evaluation of breast cancer with a computer‐aided detection system by mammographic appearance and histopathology

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