Invasive lobular carcinoma: an understudied emergent subtype of breast cancer

Mouabbi, Jason; Hassan, Amy; Lim, Bora; Hortobágyi, Gabriel N.; Tripathy, Debasish; Layman, Rachel M.

doi:10.1007/s10549-022-06572-w

Cited by 56 publications

(51 citation statements)

References 142 publications

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“…While ILC is initially associated with longer disease-free survival and a better response to adjuvant hormonal therapy than IDC, the long-term prognosis for ILC is worse than IDC; 30% of ILC patients will develop late-onset metastatic disease up to 10 years after the initial diagnosis [ 5 ]. In several retrospective studies that compared clinical and pathological responses, ILC also appeared less responsive to chemotherapy than IDC [ 6 – 8 ].…”

Section: Introductionmentioning

confidence: 99%

Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas

Lee

Castel

2022

Breast Cancer Res

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Background Invasive lobular breast carcinoma (ILC), the second most prevalent histological subtype of breast cancer, exhibits unique molecular features compared with the more common invasive ductal carcinoma (IDC). While genomic and transcriptomic features of ILC and IDC have been characterized, genome-wide chromatin accessibility pattern differences between ILC and IDC remain largely unexplored. Methods Here, we characterized tumor-intrinsic chromatin accessibility differences between ILC and IDC using primary tumors from The Cancer Genome Atlas (TCGA) breast cancer assay for transposase-accessible chromatin with sequencing (ATAC-seq) dataset. Results We identified distinct patterns of genome-wide chromatin accessibility in ILC and IDC. Inferred patient-specific transcription factor (TF) motif activities revealed regulatory differences between and within ILC and IDC tumors. EGR1, RUNX3, TP63, STAT6, SOX family, and TEAD family TFs were higher in ILC, while ATF4, PBX3, SPDEF, PITX family, and FOX family TFs were higher in IDC. Conclusions This study reveals the distinct epigenomic features of ILC and IDC and the active TFs driving cancer progression that may provide valuable information on patient prognosis.

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Section: Introductionmentioning

confidence: 99%

Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas

Lee

Castel

2022

Breast Cancer Res

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“…While ILC is initially associated with longer disease-free survival and a better response to adjuvant hormonal therapy than IDC, the long-term prognosis for ILC is worse than IDC; 30% of ILC patients will develop late-onset metastatic disease up to 10 years after the initial diagnosis (5). In several retrospective studies that compared clinical and pathological responses, ILC also appeared less responsive to chemotherapy than IDC (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas

Lee

Osmanbeyoglu

2022

Preprint

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Invasive lobular breast carcinoma (ILC), the second most prevalent histological subtype of breast cancer, exhibits unique molecular features compared with the more common invasive ductal carcinoma (IDC). While genomic and transcriptomic features of ILC and IDC have been characterized, genome-wide chromatin accessibility pattern differences between ILC and IDC remain largely unexplored. Here, we characterized tumor-intrinsic chromatin accessibility differences between ILC and IDC using primary tumors from The Cancer Genome Atlas (TCGA) breast cancer assay for transposase-accessible chromatin with sequencing (ATAC-seq) dataset. We identified distinct patterns of genome-wide chromatin accessibility in ILC and IDC. Inferred patient-specific transcription factor (TF) motif activities revealed regulatory differences between and within ILC and IDC tumors. EGR1, RUNX3, TP63, STAT6, SOX family, and TEAD family TFs were higher in ILC, while ATF4, PBX3, SPDEF, PITX family, and FOX family TFs were higher in IDC. This study reveals the distinct epigenomic features of ILC and IDC and the active TFs driving cancer progression that may provide valuable information on patient prognosis.

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“…Invasive lobular carcinoma (ILC) is the most common invasive breast carcinoma of special types, consists of 10-15% of breast cancer and its incidence rate is rising [1][2][3]. Despite the often favourable clinical and pathological features such as older patients, lower grade, ER and HER2 negative, and lower Ki67, these tumors have a higher risk of distance recurrence [4,5]. Majority of the classical-type invasive lobular carcinoma (cILC) express estrogen receptor (ER) and progesterone receptor (PR), but no overexpression or amplification of human epidermal growth factor receptor 2 (HER2) [6,7].…”

Section: Introductionmentioning

confidence: 99%

Discordance of HER2 Positive Classic Invasive Lobular Carcinoma Between IHC/FISH and Oncotype DX: A Case Report and Literature Review

Mon¹,

Wheeler²,

Lo³

et al. 2022

SCR

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The classical-type of invasive lobular carcinoma (ILC) usually expresses high levels of estrogen receptor (ER) and progesterone receptor (PR) and does not over-express human epidermal growth factor receptor 2 (HER2) and has a low level of expression of the proliferative marker. Their prognosis is comparable with those of histologic grade 1-2 invasive ductal carcinoma (IDC). HER2 status is prognostically significant and has a huge impact on clinical management; thus, its correct testing and evaluation are critical. Discordant results for HER2 between immunohistochemistry (IHC)/fluorescence in situ hybridization (FISH) and Oncotype DX (ODX) testing can be occasionally seen and cause confusion among clinicians. Here, we present a case of classical ILC (cILC), which was HER2 positive by IHC/FISH but negative by ODX. We also review relevant literature and provide a possible explanation for this discordancy and suggestions on how to approach the discordant results and guide the clinical management.

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Invasive lobular carcinoma: an understudied emergent subtype of breast cancer

Cited by 56 publications

References 142 publications

Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas

Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas

Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas

Discordance of HER2 Positive Classic Invasive Lobular Carcinoma Between IHC/FISH and Oncotype DX: A Case Report and Literature Review

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