Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature

Wakabayashi, Shun‐ichi; Kimura, Takefumi; Pham, Jonathan; Tanaka, Naoki; Higuchi, Shohei; Kobayashi, Jun’ichi; Umemura, Takeji; Iijima, Akihiro

doi:10.1007/s12328-020-01161-0

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…[ 6 ] The gene expression and synthesis of Kp capsular polysaccharide and type III pili increase and the Kp morphology changes from rodlike to round with high glucose [ 7 ] which enhances the resistance of the strain and represses the phagocytosis function of neutrophils. [ 8 ] Strict blood glucose control can significantly reduce the extrahepatic metastatic infection of Kp in diabetic patients [ 9 ]. Enema can cause septicemia in diabetic patients [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

Blindness in Right Eyes after Enema: A Case of Klebsiella pneumoniae-Related Invasive Liver Abscess Syndrome with Endophthalmitis-Caused Blindness as the First Symptom

Jin,

Zhang,

Yang

et al. 2024

Case Reports in Medicine

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We report a case of Klebsiella pneumoniae invasive liver abscess syndrome (KPILAS) with endophthalmitis-caused blindness as the first symptom after enema. The patient had diabetes, and his blood glucose was poorly controlled. She developed hematuria after four enemas for cosmetic purposes and later became blind. The eye discharge was cultured, which revealed a Klebsiella pneumoniae infection. B ultrasound did not show liver lesions, but computed tomography exhibited abscesses in the right lobe of the liver. Magnetic resonance imaging of the head indicated abscesses. These confirmed the diagnosis of invasive liver abscess syndrome. The patient was given ophthalmic and systemic anti-infection treatments, and her condition was effectively controlled. Unfortunately, the diseased eye still needed to be removed. This case underlines the necessity of avoiding unnecessary risky procedures (such as enemas) in vulnerable populations, the importance of early detection of invasive liver abscess syndrome, and the advantage of computed tomography in detecting liver abscesses.

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Section: Discussionmentioning

confidence: 99%

Blindness in Right Eyes after Enema: A Case of Klebsiella pneumoniae-Related Invasive Liver Abscess Syndrome with Endophthalmitis-Caused Blindness as the First Symptom

Jin,

Zhang,

Yang

et al. 2024

Case Reports in Medicine

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“…Patient 5, a man who has sex with men (MSM), presented twice with uncommon infections of the lumbar discs: Klebsiella pneumoniae was cultured from both blood and disc L4/5 during his first episode of spondylodiscitis. There are few case reports of Klebsiella pneumoniae causing spondylodiscitis, for example in association with urinary tract infection 19 or liver abscess 20 in Asian populations, where hypervirulent Klebsiella pneumonia could cause more metastatic spread of infection. 21 In our patient the infection was spontaneous, which has recently also been described in a Japanese and a Thai male.…”

Section: Discussionmentioning

confidence: 99%

Pyogenic spondylodiscitis in HIV-positive patients under antiretroviral therapy: A case series

Kitchen,

Gasslitter,

Gisinger

et al. 2023

Int J STD AIDS

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Background: The incidence of pyogenic spondylodiscitis has been increasing in countries of Europe and North America, probably due to an increasing number of persons with risk factors for this infection. It is unclear whether HIV infection in the era of antiretroviral therapy (ART) increases the risk for spondylodiscitis. Method: We present 7 cases of pyogenic spondylodiscitis of the cervical, thoracic, and lumbar spine in six individuals living with HIV under ART with suppressed viral load. Results: All patients presented with severe non-radicular pain and elevated inflammatory markers. Diagnosis was confirmed by magnetic resonance imaging (MRI) scan and isolation of the pathogen. Staphylococcus aureus was the causative pathogen in five patients. One patient suffered from an infection with Klebsiella pneumoniae followed by a mixed infection with Cutibacterium acnes and Bacillus circulans 18 months later. All patients needed surgical intervention, and the mean duration of antibiotic treatment was 17 weeks (range 12–26). Five patients recovered fully, including two persons who also suffered from endocarditis. One patient died from multi-organ failure. Conclusion: Spondylodiscitis may be seen more frequently in persons living with HIV as they grow older and suffer from comorbidities which put them at risk for this infection. HIV physicians should be aware of the infection and its risk factors.

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“…KPIS is a rare condition first described in 1980 in Taiwan [ 1 ], which incidence has significantly increased in the past ten years, and typically presents with hepatic involvement with abscesses formation, which is now recognized as an emerging syndrome called ILAS. Case reports of pyogenic liver abscesses have linked K. pneumoniae to the development of meningitis [ 2 ], endophthalmitis [ 3 - 5 ], otitis [ 6 ], spondylodiscitis [ 7 ], and pulmonary septic embolism [ 8 ]. To the best of our knowledge, we present the first case of multiorgan KPIS in the United States, in which at least three organ systems (pulmonary, gastrointestinal, and ophthalmic) were involved at the time of presentation.…”

Section: Discussionmentioning

confidence: 99%

Emerging Multiorgan Klebsiella pneumoniae Invasive Syndrome Leading to Septic Shock: A Case Report and Review of the Literature

Villanueva¹,

Taunk²,

Padmanabhan³

et al. 2022

Cureus

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Klebsiella pneumoniae (K. pneumoniae) is a community-acquired pathogen that typically causes pneumonia and urinary tract infections. Rarely, it can affect other organ systems such as the gastrointestinal tract, as well as the meninges, ears, eyes, and spine. We present the case of a 62-year-old male admitted with septic shock secondary to necrotizing pneumonia and multiple hepatic liver abscesses, which to the best of our knowledge, is the first reported case of multiorgan invasive K. pneumoniae infection, including the presence of a newly recognized syndrome referred as Invasive Liver Abscess Syndrome (ILAS). It is important to maintain both ILAS and K. pneumoniae invasive syndrome (KPIS) in the differential diagnosis, especially in areas of the world with a large number of tourists and immigrants, such as New York City, where the presented case took place.

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Invasive liver abscess syndrome accompanied by spondylodiscitis: a case report and review of the literature

Cited by 5 publications

References 16 publications

Blindness in Right Eyes after Enema: A Case of Klebsiella pneumoniae-Related Invasive Liver Abscess Syndrome with Endophthalmitis-Caused Blindness as the First Symptom

Blindness in Right Eyes after Enema: A Case of Klebsiella pneumoniae-Related Invasive Liver Abscess Syndrome with Endophthalmitis-Caused Blindness as the First Symptom

Pyogenic spondylodiscitis in HIV-positive patients under antiretroviral therapy: A case series

Emerging Multiorgan Klebsiella pneumoniae Invasive Syndrome Leading to Septic Shock: A Case Report and Review of the Literature

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