Invasive Infections with Nannizziopsis obscura Species Complex in 9 Patients from West Africa, France, 2004–20201

Abstract

Detection of these deep-seated infections suggests either the emergence of new fungal agents or improved means of identification.

Nannizziopsis Immune Reconstitution Inflammatory Syndrome in a Patient with HIV: First Reported Case

“…The first documented case of Nannizziopsis infection in humans was in 1982 when a 24-year-old African man presented with osteomyelitis [ 1 ] . More cases in organ transplant hosts have been subsequently described in the literature [ 2 , 3 ] . Nannizziopsis spp.…”

“…shares infective features with other dermatophytes which may cause aggressive skin disease [ 2 ] . The severe form of dermatophytosis is seen in late solid organ transplant recipients [ 1 , 3 , 4 ] . Our patient did not have any skin or nail lesions but had lung involvement, which was previously described in other cases [ 3 ] .…”

“…The severe form of dermatophytosis is seen in late solid organ transplant recipients [ 1 , 3 , 4 ] . Our patient did not have any skin or nail lesions but had lung involvement, which was previously described in other cases [ 3 ] . Brain abscesses due to Nannizziopsis have also been reported in patients with advanced HIV infection; in our case, the brain lesions are thought to be more likely cerebral toxoplasmosis, as initial improvement was noticed prior to initiation of antifungal treatment.…”

“…Brain abscesses due to Nannizziopsis have also been reported in patients with advanced HIV infection; in our case, the brain lesions are thought to be more likely cerebral toxoplasmosis, as initial improvement was noticed prior to initiation of antifungal treatment. Moreover, we did not find evidence of fungal infection on CSF (negative culture, BDG and 18S ribosomal RNA (rRNA) gene polymerase chain reaction) [ 1 , 3 ] .…”

Morocco as a possible source for acquisition of Rhinocladiella mackenziei

“…mackenziei based on morphological features under Biosafety Level 3 (BSL-3) regulations and sequencing of the ITS1-5.8S-ITS2 region of rDNA (GenBank accession number: MZ128136). DNA extraction method [ 11 ] and PCR protocol [ 12 ] have been described elsewhere. MRI reevaluation in August 2014 showed expansion of the lesion and related edema.…”