Invasive infection due to Saprochaete capitata in a young patient with hematological malignancies

Abstract

We report a case of invasive infection due to Saprochaete capitata in a patient with hematological malignancies after chemotherapy treatment and empiric antifungal therapy with caspofungin. Although severely immunocompromised the patient survived been treated with amphotericin B lipid complex associated with voriconazole.

Molecular epidemiology and antifungal susceptibility ofSaprochaete capitata(Blastoschizomyces capitatus) isolates causing nosocomial infection in Kayseri/Turkey

“…[15] Nearly half of our patients (45%) were receiving empirical caspofungin therapy until S. capitata diagnosis. Additionally, caspofungin is also widely used for empiric antifungal treatment of febrile neutropenic patients in our centre.…”

“…[5,8,14] S. capitata is a pathogen causing nosocomial fungal infections in patients with cancer, particularly those with hematological malignancies and neutropenia. [10,11,15,16] This fungus was reported to have caused a nosocomial outbreak associated with contaminated milk in a haematogical unit. [11] There are a few studies in the literature investigating pathogenic S. capitata strains, antifungal resistance, and genotyping.…”

“…[11] There are a few studies in the literature investigating pathogenic S. capitata strains, antifungal resistance, and genotyping. [14][15][16][17] The purpose of this study was to evaluate the demographic features of patients with nosocomial S. capitata infections, the antifungal susceptibility of the pathogens and the isolates genotyping and identification, using the typing methodology of repetitive sequence PCR (repPCR) by means of the DiversiLab System (BioMerieux, France) and DNA sequencing analysis.…”

Rol de la cirugía en el manejo de la infección invasora por Saprochaete capitata

“…Similarmente, las equinocandinas muestran CIMs más altas que las observadas en otras levaduras y, en algunos casos, incluso resistencia 10 . Aún cuando falta mejor correlación entre los resultados in vivo e in vitro, anfotericina B (en monoterapia o combinada con 5-flurocitosina o voriconazol) y voriconazol se han sugerido como terapias de primera línea para esta infección 2,5,7,8,14,24 . Existe un caso publicado de manejo exitoso de la infección hepatoesplénica con terapia combinada de anfotericina e interferón-g 24 .…”

Magnusiomyces clavatus infection in a child after allogeneic hematotopoetic stem cell transplantation: Diagnostic and therapeutic implications

“…Approximately one hundred cases of IFD due to M. clavatus have been reported in adults, while only few cases of Magnusiomyces capitatus (Saprochaete capitata) fungemia have been described in children [1], [2], [3], [6], [7].…”