Invasive <i>Bordetella pertussis</i> Infection in Infants: A Case Report

Liao, Yang; Li, Wei ran; Zhu, Yu; Luo, Shuang; Liao, Qiong; Wan, Chao

doi:10.1093/ofid/ofac478

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Transmission of Bordetellae is typically attributed to respiratory droplets from coughing patients ( Nieves and Heininger, 2016 ) and does not normally invade beyond the respiratory tract ( Stevenson and Roberts, 2003 ). The bacteria can colonize in the respiratory tract, blood, and body fluids (such as cerebrospinal fluid; Liao et al, 2022 ), and B. bronchiseptica persist in a variety of environments outside the host, including water and on surfaces ( Porter et al, 1991 ). Though no current reports manifest the presence of Bordetella in arthropods, our findings imply that Dermacentor nuttalli could be a potential vector for Bordetella , contradicting other reports that solely suggest transmission and infectious in mammals ( Mattoo and Cherry, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

Differential microbial composition in parasitic vs. questing ticks based on 16S next-generation sequencing

Zhang,

Han,

Zhou

et al. 2023

Front. Microbiol.

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IntroductionAs tick-borne diseases rise to become the second most prevalent arthropod-transmitted disease globally, the increasing investigations focus on ticks correspondingly. Factors contributed to this increase include anthropogenic influences, changes in vertebrate faunal composition, social-recreational shifts, and climatic variation. Employing the 16S gene sequence method in next-generation sequencing (NGS) allows comprehensive pathogen identification in samples, facilitating the development of refined approaches to tick research omnidirectionally.MethodsIn our survey, we compared the microbial richness and biological diversity of ticks in Wuwei City, Gansu province, differentiating between questing ticks found in grass and parasitic ticks collected from sheep based on 16S NGS method.ResultsThe results show Rickettsia, Coxiella, and Francisella were detected in all 50 Dermacentor nuttalli samples, suggesting that the co-infection may be linked to specific symbiotic bacteria in ticks. Our findings reveal significant differences in the composition and diversity of microorganisms, with the Friedmanniella and Bordetella genera existing more prevalent in parasitic ticks than in questing ticks (p < 0.05). Additionally, the network analysis demonstrates that the interactions among bacterial genera can be either promotive or inhibitive in ticks exhibiting different lifestyles with the correlation index |r| > 0.6. For instance, Francisella restrains the development of 10 other bacteria in parasitic ticks, whereas Phyllobacterium and Arthrobacter enhance colonization across all tick species.DiscussionBy leveraging NGS techniques, our study reveals a high degree of species and phylogenetic diversity within the tick microbiome. It further highlights the potential to investigate the interplay between bacterial genera in both parasitic and questing ticks residing in identical habitat environments.

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Section: Discussionmentioning

confidence: 99%

Differential microbial composition in parasitic vs. questing ticks based on 16S next-generation sequencing

Zhang,

Han,

Zhou

et al. 2023

Front. Microbiol.

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“…An increase in white blood cells typically occurs in cases of severe pertussis, which is defined by pneumonia with refractory hypoxemia and cardiogenic shock [3,4]. Although pertussis is a common infection worldwide, reports of invasive pertussis in the bloodstream to date are rare and have involved immunocompromised patients [5]. This infection can be under-diagnosed, especially during the winter period because it is possible to confuse whooping cough symptoms with those of other common respiratory infections [6].…”

Section: Introductionmentioning

confidence: 99%

Whooping Cough Cases Increase in Central Italy after COVID-19 Pandemic

Linardos,

Coltella,

Ranno

et al. 2024

Antibiotics

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Pertussis continues to be a highly contagious respiratory infection, especially in children, with cyclical peaks of disease spread every three to five years. Here, we report relevant cases of B. pertussis infection between August 2023 and January 2024, and compare them with B. pertussis prevalence in pediatric patients admitted to the Reference Italian Pediatric Hospital, located in Rome, from January 2015 to July 2023. A total of 5464 tests for B. pertussis were performed during the study period, and 6.9% were positive. At the time of the COVID-19 pandemic, there was a sharp decrease in the presence of B. pertussis, which reappeared only in August 2023, recording five new cases. All five children presented with paroxysmal cough 5 to 10 days before admission. Four patients had other mild respiratory symptoms and moderate B. pertussis DNA levels (Ct mean: 26). Only one child, with very high B. pertussis DNA levels (Ct: 9), presented with severe respiratory failure. The patients with mild/moderate infection achieved clinical recovery while the patient with the severe manifestation died of cardiac arrest. These observations highlight the reemergence of pertussis even in vaccinated countries and its association with morbidity and mortality especially in young children. This emphasizes the importance of rapid diagnosis to immediately implement appropriate treatment and monitoring of immune status.

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Invasive Bordetella pertussis Infection in Infants: A Case Report

Cited by 2 publications

References 7 publications

Differential microbial composition in parasitic vs. questing ticks based on 16S next-generation sequencing

Differential microbial composition in parasitic vs. questing ticks based on 16S next-generation sequencing

Whooping Cough Cases Increase in Central Italy after COVID-19 Pandemic

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