Invasive group A streptococcal infections in North West England: epidemiology, risk factors and fatal infection

Blagden, Sarah; Watts, Vicky; Verlander, Neville Q.; Pegorie, Matthieu

doi:10.1016/j.puhe.2020.06.007

Cited by 9 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increment in the frequency of invasive diseases caused by S. pyogenes, including pneumonia, has been reported in several countries. 6,[15][16][17] In a study conducted in France on the epidemiology of community-acquired pleural empyema, the frequency of pneumococcal infection declined from 79.1% in 2009 to 36.4% in 2017 (P < 0.001), with S. pyogenes being the leading cause in the later years of the study period (2015-2017, 45.5%). 4 Because of the stable prevalence of S. aureus CAP, recent updates to guidelines recommend maintaining aminopenicillins as first-line treatment for most cases of CAP, since they remain highly active against S. pyogenes and S. pneumoniae.…”

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus Community-acquired Pneumonia in Children After 13-Valent Pneumococcal Vaccination (2008–2018): Epidemiology, Clinical Characteristics and Outcomes

Aguilera‐Alonso

Nieto²,

Montojo

et al. 2022

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

Background:The epidemiology of community-acquired pneumonia (CAP) has changed, influenced by sociosanitary conditions and vaccination status. We aimed to analyze the recent epidemiology of bacterial CAP in hospitalized children in a setting with high pneumococcal vaccination coverage and to describe the clinical characteristics of pediatric Staphylococcus aureus CAP. Methods: Children <17 years old hospitalized from 2008 to 2018 with bacterial CAP in 5 tertiary hospitals in Spain were included. Cases with pneumococcal CAP were randomly selected as comparative group following a case-control ratio of 2:1 with S. aureus CAP. Results: A total of 313 bacterial CAP were diagnosed: Streptococcus pneumoniae CAP (n = 236, 75.4%), Streptococcus pyogenes CAP (n = 43, 13.7%) and S. aureus CAP (n = 34, 10.9%). Throughout the study period, the prevalence of S. pyogenes increased (annual percentage change: +16.1% [95% CI: 1.7-32.4], P = 0.031), S. pneumoniae decreased (annual percentage change: -4.4% [95 CI: -8.8 to 0.2], P = 0.057) and S. aureus remained stable. Nine isolates of S. aureus (26.5%) were methicillin-resistant. Seventeen cases (50%) with S. aureus CAP had some pulmonary complication and 21 (61.7%) required intensive care. S. pneumoniae CAP showed a trend toward higher prevalence of pulmonary complications compared with S. aureus CAP (69.1% vs. 50.0%, P = 0.060), including higher frequency of pulmonary necrosis (32.4% vs. 5.9%, P = 0.003). Conclusions:The incidence of S. aureus CAP in children remained stable, whereas the prevalence of pneumococcal CAP decreased and S. pyogenes CAP increased. Patients with S. aureus presented a high frequency of severe outcomes, but a lower risk of pulmonary complications than patients with S. pneumoniae.

show abstract

Section: Discussionmentioning

confidence: 99%

Staphylococcus aureus Community-acquired Pneumonia in Children After 13-Valent Pneumococcal Vaccination (2008–2018): Epidemiology, Clinical Characteristics and Outcomes

Aguilera‐Alonso

Nieto²,

Montojo

et al. 2022

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

show abstract

“…Globally, an increase in the incidence of iGAS over time has also been observed in many countries, including Canada (( 9 – 12 )). Previous analyses have hypothesized that the observed increase is linked to both the increase in genetic diversity of circulating emm types and compounding societal risk factors, such as homelessness and substance use (( 10 , 13 – 17 )). Although the factors associated with the increased incidence seen in the Island Health region since 2019, and particularly in 2022, are not completely clear, it is likely that multiple factors have contributed to the observed trends.…”

Section: Discussionmentioning

confidence: 99%

Invasive group A streptococcal (iGAS) surveillance in Island Health, British Columbia, 2022

Nwosu,

Schut,

Arlotti Wood

et al. 2023

CCDR

View full text Add to dashboard Cite

Background Invasive group A streptococcal disease (iGAS) is caused by Streptococcus pyogenes group A bacteria. In 2022, multiple disease alerts for iGAS in the Island Health region, in the context of increased infections in the paediatric population in Europe and the United States, prompted further investigation into local trends. This surveillance study summarizes epidemiological trends of iGAS in the region covered by Island Health, a regional health authority in British Columbia, in 2022. Methods In British Columbia, iGAS is a reportable disease; all confirmed cases are reported to the regional authority and the provincial health authority (BC Centre for Disease Control). Island Health’s iGAS surveillance system is passive and collects information on cases that are identified through laboratory testing. Surveillance data were summarized for 2022 and compared with historical data from 2017–2021. Results In 2022, the incidence rate was 11.4 cases per 100,000 population (n=101), the highest observed rate in the last six years. The median age of cases was 53 years, with a range of 0–96 years, and 64% of cases were male. The highest risk of infection was reported in men 40–59 years of age, with an incidence rate of 21.3 cases per 100,000 population. The most common emm types were emm 92 (n=14), emm 49 (n=13), and emm 83 (n=12). Overall, 85% (n=86) of cases were hospitalized, 21% (n=21) were admitted to the intensive care unit, and 6% (n=6) died. Conclusion This study highlights that the incidence of iGAS in the Island Health region continued to increase throughout the coronavirus disease 2019 (COVID-19) pandemic, reaching its highest annual rate in 2022. In contrast to reports from Europe and the United States, there was no notable increase in infections in the paediatric population. Given the sustained increase in iGAS activity, continued monitoring and description of the epidemiology of these cases on a regular basis is imperative.

show abstract

“…Recent analyses report an increasing incidence of S. pyogenes infections with a high case fatality in the older population (Shakoor et al, 2017;Meehan et al, 2018;Blagden et al, 2020;Vilhonen et al, 2020;Bläckberg et al, 2022;Thomson et al, 2022). The most prevalent form of clinical presentation of invasive S. pyogenes infection is bacteremia (75%), followed by focus without bacteremia (19%) and necrotizing fasciitis (7%; Meehan et al, 2018).…”

Section: Epidemiologymentioning

confidence: 99%

Novel evidence on sepsis-inducing pathogens: from laboratory to bedside

Gatica,

Fuentes,

Rivera-Asín

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Sepsis is a life-threatening condition and a significant cause of preventable morbidity and mortality globally. Among the leading causative agents of sepsis are bacterial pathogens Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, and Streptococcus pyogenes, along with fungal pathogens of the Candida species. Here, we focus on evidence from human studies but also include in vitro and in vivo cellular and molecular evidence, exploring how bacterial and fungal pathogens are associated with bloodstream infection and sepsis. This review presents a narrative update on pathogen epidemiology, virulence factors, host factors of susceptibility, mechanisms of immunomodulation, current therapies, antibiotic resistance, and opportunities for diagnosis, prognosis, and therapeutics, through the perspective of bloodstream infection and sepsis. A list of curated novel host and pathogen factors, diagnostic and prognostic markers, and potential therapeutical targets to tackle sepsis from the research laboratory is presented. Further, we discuss the complex nature of sepsis depending on the sepsis-inducing pathogen and host susceptibility, the more common strains associated with severe pathology and how these aspects may impact in the management of the clinical presentation of sepsis.

show abstract

Invasive group A streptococcal infections in North West England: epidemiology, risk factors and fatal infection

Cited by 9 publications

References 20 publications

Staphylococcus aureus Community-acquired Pneumonia in Children After 13-Valent Pneumococcal Vaccination (2008–2018): Epidemiology, Clinical Characteristics and Outcomes

Staphylococcus aureus Community-acquired Pneumonia in Children After 13-Valent Pneumococcal Vaccination (2008–2018): Epidemiology, Clinical Characteristics and Outcomes

Invasive group A streptococcal (iGAS) surveillance in Island Health, British Columbia, 2022

Novel evidence on sepsis-inducing pathogens: from laboratory to bedside

Contact Info

Product

Resources

About