Invasive fungal infection by Aspergillus flavus in immunocompetent hosts: A case series and literature review

García-Giraldo, Ana María; Mora, Bárbara; Loaiza-Castaño, Jorge Mario; Cedano, Jorge; Rosso, Fernando

doi:10.1016/j.mmcr.2018.10.006

Cited by 13 publications

(8 citation statements)

References 21 publications

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“…This is mainly because a great number of A. flavus isolates are able to produce carcinogenic aflatoxins, which contaminate food and feeds to cause tremendous economic losses. Moreover, A. flavus is the second most common causal agent of invasive aspergillosis (Garcia‐Giraldo et al ). Therefore, A. flavus is perceived as a threat to human and animal health.…”

Section: Introductionmentioning

confidence: 99%

Genome‐wide nucleotide variation distinguishesAspergillus flavusfromAspergillus oryzaeand helps to reveal origins of atoxigenicA. flavusbiocontrol strains

Chang

2019

J Appl Microbiol

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Aims: To use genome-wide single nucleotide polymorphisms (total SNPs) to develop a molecular method for distinguishing Aspergillus flavus and Aspergillus oryzae. Methods and Results: Thirteen A. flavus and eleven A. oryzae genome sequences were obtained from the National Center for Biotechnology Information. These sequences were analysed by Mauve, a multiple-genome alignment program, to extract total SNPs between isolates of A. flavus, A. oryzae, or the two species. Averages of total SNPs of A. flavus isolates belonging to the same sclerotial morphotype (L-type = 178 952 AE 14 033; S-type = 133 188 AE 16 430) and A. oryzae isolates (152 336 AE 49 124) were consistently lower than those between the morphotypes and between the two species. Averages of total SNPs for L-type vs S-type (300 116 AE 1562) and S-type A. flavus vs A. oryzae (301 797 AE 4123) were similar but were 36% greater than that of L-type A. flavus vs A. oryzae (226 240 AE 10 779). Based on the devised criterion, ATCC 12892, Aspergillus oryzae (Ahlburg) Cohn, which had an averaged total SNPs 10-fold greater than that of other A. oryzae isolates, was determined to be close to Aspergillus parasiticus. Atoxigenic A. flavus field isolates, WRRL1519 and NRRL35739, were shown to more closely resemble A. oryzae than toxigenic L-type A. flavus. Biocontrol strains AF36 and K49 were genetically close to toxigenic L-type A. flavus. NRRL21882, the active agent of the commercialized biocontrol product Afla-Guard â GR, was genetically distant from all other A. flavus isolates. Conclusions: The close genetic relatedness between A. flavus and A. oryzae was confirmed and the evolutionary origins of atoxigenic A. flavus biocontrol strains were revealed. Significance and Impact of the Study: The study provides a greater understanding of genome similarity and dissimilarity between A. flavus and A. oryzae. The method can be an auxiliary technique for identifying A. flavus, A. oryzae.

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Section: Introductionmentioning

confidence: 99%

Genome‐wide nucleotide variation distinguishesAspergillus flavusfromAspergillus oryzaeand helps to reveal origins of atoxigenicA. flavusbiocontrol strains

Chang

2019

J Appl Microbiol

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“…One possibility for this is small sample size. There are only few cases of IFS on immunocompetent hosts published in the previous literatures [ 23 ]. Though less prevalent, immunocompetent patients may develop AIFS as well, and they may also be at risk of suffering long-term complications, as two of our patients developed permanent neurologic sequelae and another one died of intracranial hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

Invasive Fungal Rhinosinusitis with and without Orbital Complications: Clinical and Laboratory Differences

Twu

Kuo

et al. 2021

JoF

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Background: Invasive fungal rhinosinusitis (IFS) is a rare but often fatal disease. There are limited studies regarding IFS with orbital complications (IFSwOC). The present study aimed to identify the clinical signs associated with IFSwOC and prognosticators of the disease. Methods: A retrospective case series was conducted of patients histopathologically confirmed IFS or fungal rhinosinusitis with clinically apparent neuro-orbital complications who underwent surgery between 2008 and 2018. Demographic data, presenting symptoms and signs, culture data, laboratory results, and patient outcomes were obtained from medical records. Results: A total of 38 patients were identified, including 9 patients with IFSwOC, and 29 patients with IFS without orbital complications (IFSsOC). The clinical signs associated with developing orbital complications include headache, fever, sphenoid sinus, or posterior ethmoid sinus involvement, CRP level ≥ 1.025 mg/dL, or ESR level ≥ 46.5 mm/h. In IFSwOC group, male, posterior ethmoid sinus involvement, WBC count ≥ 9000 μL, CRP level ≥ 6.91 mg/dL, or ESR level ≥ 69 mm/h were correlated with a significantly poorer prognosis. Conclusion: IFS patients with sphenoid or posterior ethmoid sinus involvement, headache or fever as presenting symptoms, elevated CRP, and ESR level were at risk of developing orbital complications. Timely surgical debridement followed by systemic antifungal treatment may improve treatment outcomes.

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“…Aspergillus flavus, a member of the Ascomycota, produces mycotoxins and infects corn, cotton, peanuts, and tree nuts. It is also the second most common causal agent of invasive aspergillosis in humans (1). Wild-type A.…”

Section: Announcementmentioning

confidence: 99%

Genome Sequence of an Aspergillus flavus CA14 Strain That Is Widely Used in Gene Function Studies

Chang

Scharfenstein

Mack

et al. 2019

Microbiol Resour Announc

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Invasive fungal infection by Aspergillus flavus in immunocompetent hosts: A case series and literature review

Cited by 13 publications

References 21 publications

Genome‐wide nucleotide variation distinguishesAspergillus flavusfromAspergillus oryzaeand helps to reveal origins of atoxigenicA. flavusbiocontrol strains

Genome‐wide nucleotide variation distinguishesAspergillus flavusfromAspergillus oryzaeand helps to reveal origins of atoxigenicA. flavusbiocontrol strains

Invasive Fungal Rhinosinusitis with and without Orbital Complications: Clinical and Laboratory Differences

Genome Sequence of an Aspergillus flavus CA14 Strain That Is Widely Used in Gene Function Studies

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