Invasive form of ciliated muconodular papillary tumor of the lung: A case report and review of the literature

Abstract

We report a case of a 67-year-old woman with an invasive ciliated muconodular papillary tumor (CMPT) that developed in her right middle lobe. The current tumor was incidentally detected during a follow-up imaging examination for a large cell carcinoma that was resected 10 years previously. Partial removal of the middle lobe showed a 2 cm-sized, solid and myxoid tumor located in the peripheral region. Histologically, this tumor primarily consisted of ciliated columnar cells, mucous cells, and basal cells, all of which had relatively swollen nuclei and were proliferating in a lepidic or papillary/micropapillary manner. These features were consistent with those of previously reported CMPT. In addition, atypical spindle tumor cells with more swollen nuclei, which were partly continuous to less atypical basal tumor cells, were focally found and invaded fibrous stroma in a reticular fashion. Immunohistochemically, both basal cells and atypical spindle tumor cells were positive for pancytokeratin, cytokeratin 5/6, and p40. Increased p53 positivity was found in these invading spindle cells compared with basal tumor cells. Neither BRAF V600E nor V600K mutation was detected. We concluded that this tumor was an extremely rare invasive case of CMPT, possibly representing malignant transformation of basal tumor cell components of CMPT.

Ciliated Muconodular Papillary Tumors of the Lung: Distinct Molecular Features of an Insidious Tumor

“…According to the immunohistochemistry results reported in previous studies, in many cases, CK7/CEA/TTF-1 expressions were positive, and most CK20 expressions were negative. These findings are very similar to those for adenocarcinoma ( Sato et al, 2010 ; Chuang et al, 2014 ; Ishikawa et al, 2016 ; Kamata et al, 2016 ; Kon et al, 2016 ; Lau et al, 2016 ; Jin et al, 2017 ; Kim et al, 2017 ; Taguchi et al, 2017 ; Udo et al, 2017 ; Miyai et al, 2018 ) and indicate that CMPTs are potential malignant tumors.…”

Distal‐type bronchiolar adenoma of the lung expressing p16INK4a – morphologic, immunohistochemical, ultrastructural and genomic analysis – report of a case and review of the literature

“…Ishikawa 1 reported the first case in 2002, and named it ciliated muconodular papillary tumor. Literature review indicated a total of 68 cases reported to date 1–10 . The clinicopathological features of the previously reported cases are summarized in Table 1.…”

“…Literature review indicated a total of 68 cases reported to date. [1][2][3][4][5][6][7][8][9][10] The clinicopathological features of the previously reported cases are summarized in Table 1. The tumor size ranged from 2 to 15 mm.…”

Ciliated muconodular papillary tumor of the lung: report of two cases and review of the literature

“…Miyai et al . [6] reported the clinical use of preoperative positron emission tomography–CT scanning without any positive findings. Non-operative biopsy, including bronchoscopy and percutaneous puncture, is also difficult to perform.…”