Invasive cervical carcinoma: role of MR imaging in pretreatment work-up--cost minimization and diagnostic efficacy analysis.

Hricak, Hedvig; Powell, C. Bethan; Yu, Kyle K.; Washington, Eleby R.; Subak, Leslee L.; Stern, Jeffrey L.; Cisternas, M G; Arenson, Ronald L.

doi:10.1148/radiology.198.2.8596840

Cited by 175 publications

(59 citation statements)

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“…[51][52][53] MRI also has been shown to be a cost-effective staging technique. Hricak et al 54 reported that patients with cervical cancer who underwent MRI as the initial imaging procedure for staging required fewer tests and procedures compared with those who underwent standard clinical staging. The resultant cost savings was significant, not only in terms of the cost of saved procedures but also in terms of the overall cost of treatment when treatment was altered based on MRI findings.…”

Section: Mrimentioning

confidence: 99%

Imaging in cervical cancer

Follen

Levenback

Iyer

et al. 2003

Cancer

126

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Section: Mrimentioning

confidence: 99%

Imaging in cervical cancer

Follen

Levenback

Iyer

et al. 2003

Cancer

126

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“…Clinical palpation is also a subjective method and has significant interobserver variability [26][27][28]. More recent studies have shown that the three-dimensional quantitative imaging-based method of tumor size measurement using MRI is highly accurate in determining actual tumor size and extent to surrounding tissue [2,3,15,16,[29][30][31][32][33][34][35][36][37]. MRI has been recognized as an important imaging modality for the management of cervical cancer because of its multiplanar capability and distinct tissue contrast, particularly between tumor and surrounding normal tissue [9].…”

Section: Discussionmentioning

confidence: 99%

Method of Tumor Volume Evaluation using Magnetic Resonance Imaging for Outcome Prediction in Cervical Cancer Treated with Concurrent Chemotherapy and Radiotherapy

Kim

2008

International Journal of Radiation Oncology*Biology*Physics

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“…This high NPV for bladder invasion suggests that the low pre-test probability of bladder involvement in early stage cervical cancer does not justify routine cystoscopy [7,13]. However, for the positive predictive value (PPV) of MRI for bladder invasion, studies show highly discrepant values ranging from 7% to 100% [6][7][8][9][10].…”

Section: Significance Of Bladder Wall Invasion On Mri In Cervical Cancermentioning

confidence: 99%

Prognostic significance of MRI-detected bladder muscle and/or serosal invasion in patients with cervical cancer treated with radiotherapy

Nam

Huh²,

Park³

et al. 2010

British Journal of Radiology

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ABSTRACT. In cervical cancer, the prognostic significance of bladder wall invasion on MRI without pathological evidence of mucosal invasion is not known. From 454 consecutive patients with cervical cancer who were treated with radiation, we reviewed images and analysed the outcome of 92 patients with the Federation of International Gynecology and Obstetrics (FIGO) stage IIIB-IVA. We analysed the patients in three groups, normal, wall (muscle and/or serosal) invasion and mucosal invasion, according to the findings on the MRI. Kaplan-Meier life table analysis and the log-rank test were used to assess the survival rates and differences according to prognostic factors. MRI detected abnormalities in the bladder wall in 42 patients (45.6%): wall invasion in 24 and mucosal invasion in 18. 5 of 18 patients, suspected on MRI to have mucosal invasion, showed no pathological evidence of mucosal invasion. Median follow-up period was 34 months. 3-year cause-specific survival (CSS) in the normal group compared with the wall invasion group was 76.2% vs 71.4% (p50.48). 3-year CSS for the wall invasion group compared with the mucosal invasion group was 71.4% vs 54.3% (p50.04). Mucosal invasion on MRI (p50.03) and concurrent chemoradiotherapy (p50.01) was significant for CSS. The prognosis for patients with cervical cancer with evidence of muscle and/or serosal invasion of the bladder on MRI may not differ from that for patients without abnormality on MRI. In patients with the MRI finding of bladder mucosal invasion, further studies should be conducted regarding the role of cystoscopy to determine the need for pathological confirmation.

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Invasive cervical carcinoma: role of MR imaging in pretreatment work-up--cost minimization and diagnostic efficacy analysis.

Abstract: Guidelines for the pretreatment work-up of clinical stage Ib cervical cancer need revision. MR imaging should be used as an adjunct to clinical evaluation.

Cited by 175 publications

References 0 publications

Imaging in cervical cancer

Imaging in cervical cancer

Method of Tumor Volume Evaluation using Magnetic Resonance Imaging for Outcome Prediction in Cervical Cancer Treated with Concurrent Chemotherapy and Radiotherapy

Prognostic significance of MRI-detected bladder muscle and/or serosal invasion in patients with cervical cancer treated with radiotherapy

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