Invasive Carcinoma Arising in Microglandular Adenosis of the Breast: A Case Report and Literature Review

Oh, Seung Won; Lim, Hyo Soon; Baek, Jang Mi; Lee, Ji Shin

doi:10.5812/iranjradiol.63463

Cited by 3 publications

(3 citation statements)

References 12 publications

(11 reference statements)

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“…The latter showed a lobulated, heterogeneous hypoechoic mass on US. Oh et al [ 21 ] have reported one case of invasive carcinoma arising in MGA. Mammogram showed an irregular isodense mass with a spiculated margin and irregular hypoechoic mass in US examination.…”

Section: Discussionmentioning

confidence: 99%

Breast adenoid cystic carcinoma arising in microglandular adenosis: A case report and review of literature

An¹,

Woo²,

Kim³

et al. 2021

WJCC

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BACKGROUND Breast adenoid cystic carcinoma (AdCC) is a rare invasive carcinoma composed of epithelial and myoepithelial cells. Microglandular adenosis (MGA) is a rare benign proliferative lesion consisting of small, uniform, and round glands formed by a single layer of epithelial cells and basement membrane without a myoepithelial cell layer. MGA may progress to atypical MGA and carcinoma arising in MGA. Among various invasive carcinomas from MGA, AdCC has been rarely reported. Here, we report a case of AdCC arising in MGA. CASE SUMMARY A 59-year-old woman was diagnosed with a newly developed density on a routine mammogram. The density was similar to or slightly lower than that of the breast parenchyma. Sonography showed an irregular mass with a slightly higher echo than that of fat. Magnetic resonance imaging showed an irregular mass with a similar T1 signal intensity and a slightly higher T2 signal intensity compared to muscles or the breast parenchyma. The lesion showed heterogeneous internal enhancement with an initially slow and delayed persistent enhancing pattern. Microscopically, the tumor was composed of invasive AdCC, in situ AdCC, and MGA. AdCC is composed of basaloid and ductal epithelial cells forming cribriform or solid sheets, or haphazardly scattered small cribriform or tubular glands. MGA showed small glands with a single epithelial lining and retained lumen. S-100 staining was strongly positive in MGA area. The patient underwent breast-conserving surgery with sentinel lymph node biopsy. CONCLUSION Breast AdCC arising in MGA showed unique imaging findings that was different from usual invasive cancer.

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Section: Discussionmentioning

confidence: 99%

Breast adenoid cystic carcinoma arising in microglandular adenosis: A case report and review of literature

An¹,

Woo²,

Kim³

et al. 2021

WJCC

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“…No specific predisposing factors have been identified. MGA is often an incidental finding but may present as a mammographic density or calcifications [2][3][4][5][6]. MGA is often inconspicuous on gross examination though it has been described as a poorly defined nodularity or mass.…”

Section: Introductionmentioning

confidence: 99%

Luminal-Type Invasive Carcinoma in Association With Microglandular Adenosis/Atypical Microglandular Adenosis: A Case Report and Molecular Comparison

Jaramillo¹,

Nazario-Toole²,

Xia³

et al. 2023

Cureus

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Microglandular adenosis (MGA) is a proliferative breast lesion composed of small, uniform glands lacking a myoepithelial cell layer while still invested by the basement membrane. The glands percolate haphazardly through the breast parenchyma rather than maintaining a lobular architecture, typical of other forms of adenosis. MGA is a benign lesion though atypical forms have been well described, often in close association with carcinoma. MGA, atypical MGA (AMGA), and the vast majority of MGA-associated carcinomas (MGACA) are negative for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2) by immunohistochemistry. In light of these findings and early molecular studies, MGA is hypothesized to represent a clonal process and nonobligate precursor of basal-type breast carcinomas. We present the case of a 58-year-old woman and the first published molecular comparison of a luminal-type invasive ductal carcinoma with its associated MGA/AMGA. Analysis of small nucleotide variants (SNVs) revealed that 63% of the SNVs identified in the MGA were present in the AMGA while only 10% of them were present in the MGACA, suggesting a direct relationship between MGA and AMGA but not MGA and MGACA.

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“…The benign areas of the tumor will show strong positivity for S-100 whereas invasive areas will have patchy positivity for S-100 immunohistochemical stain. 1,8 Both benign and malignant tumors of breast can be the differential diagnosis of microglandular adenosis.…”

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confidence: 99%

A rare borderline neoplastic lesion of breast, a mimicker and precursor of carcinoma

Banushree C S

2024

IJPO

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Invasive Carcinoma Arising in Microglandular Adenosis of the Breast: A Case Report and Literature Review

Cited by 3 publications

References 12 publications

Breast adenoid cystic carcinoma arising in microglandular adenosis: A case report and review of literature

Breast adenoid cystic carcinoma arising in microglandular adenosis: A case report and review of literature

Luminal-Type Invasive Carcinoma in Association With Microglandular Adenosis/Atypical Microglandular Adenosis: A Case Report and Molecular Comparison

A rare borderline neoplastic lesion of breast, a mimicker and precursor of carcinoma

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