Invasive candidiasis and candidemia: from current opinions to future perspectives

Rueping, M.; Vehreschild, Jörg J.; Cornely, Oliver A.

doi:10.1517/13543780902911440

Cited by 31 publications

(16 citation statements)

References 103 publications

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“…The predisposing factors for the development of candidemia in our study were similar to those described previously (28,29,34,35). The presence of CVCs and previous administration of antibiotics were the principal conditions associated with increased risk.…”

Section: Discussionsupporting

confidence: 88%

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Retrospective Analysis of Epidemiology and Prognostic Factors for Candidemia at a Hospital in China, 2000^|^ndash;2009

Zhang

et al. 2012

Jpn J Infect Dis

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SUMMARY:The incidence of candidemia has increased in recent years. This paper reports a retrospective analysis of 270 cases of candidemia occurring from January 2000 to December 2009 at a teaching hospital in China. Demographic and clinical data were collected from patient medical records and the hospital's laboratory database. Candida albicans (35.9z) was the most prevalent species isolated, followed by C. tropicalis (21.8z) and C. glabrata (13.0z). Antifungal susceptibilities to fluconazole, flucytosine, and amphotericin B tended to decline over the study period. The most common risk factors were the presence of central venous catheters, endotracheal intubation, hypoproteinemia, renal failure, and concurrent bacteremia. In the 181 (67.0z) patients who died during hospitalization, endotracheal intubation, hypoproteinemia, and C. albicans were the major factors associated with mortality. This study highlights the importance of considering the possibility of invasive Candida infection in patients exposed to these risk factors.

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Section: Discussionsupporting

confidence: 88%

“…States have suggested that after C. albicans, the predominant species isolated from candidemia patients are C. glabrata and C. parapsilosis (11,22,28,29). Among the non-albicans Candida spp., C. parapsilosis is frequently associated with candidemia outbreaks in neonatal centers, burn units, and intensive care settings (30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of Epidemiology and Prognostic Factors for Candidemia at a Hospital in China, 2000^|^ndash;2009

Zhang

et al. 2012

Jpn J Infect Dis

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“…The current rise in fungal infections correlates with the widespread use of broad-spectrum antibacterial agents, prolonged hospitalization of critically ill patients, and the increased number of immunocompromised patients. Candida species comprise the fourth most common cause of nosocomial bloodstream infections, and Cryptococcus neoformans is the most common cause of fungus-related mortality in HIV-infected patients (15,19). While Candida albicans is still involved in more than half of all Candida-related bloodstream infections, an increase in recovery of non-C. albicans Candida spp., Rhodotorula spp., Trichosporon spp., and Malassezia spp.…”

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confidence: 99%

Evaluation of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Clinically Important Yeast Species

et al. 2010

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“…andida biofilms have been associated with many infections, including catheter-related fungemia, endocarditis, bone and joint infections, and others, with high morbidity and considerable mortality (1)(2)(3). In addition, oropharyngeal and vaginal in vivo models have demonstrated that mucosal Candida infections are due to the development of biofilms, a process controlled by morphogenetic and biofilm regulators (4,5).…”

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confidence: 99%

Species-Specific and Drug-Specific Differences in Susceptibility of Candida Biofilms to Echinocandins: Characterization of Less Common Bloodstream Isolates

Simitsopoulou

Peshkova

Tasina

et al. 2013

Antimicrob Agents Chemother

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e Candida species other than Candida albicans are increasingly recognized as causes of biofilm-associated infections. This is a comprehensive study that compared the in vitro activities of all three echinocandins against biofilms formed by different common and infrequently identified Candida isolates. We determined the activities of anidulafungin (ANID), caspofungin (CAS), and micafungin (MFG) against planktonic cells and biofilms of bloodstream isolates of C. albicans (15 strains), Candida parapsilosis (6 strains), Candida lusitaniae (16 strains), Candida guilliermondii (5 strains), and Candida krusei (12 strains) by XTT [2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide] assay. Planktonic and biofilm MICs were defined as >50% fungal damage. Planktonic cells of all Candida species were susceptible to the three echinocandins, with MICs of <1 mg/liter. By comparison, differences in the MIC profiles of biofilms in response to echinocandins existed among the Candida species. Thus, C. lusitaniae and C. guilliermondii biofilms were highly recalcitrant to all echinocandins, with MICs of >32 mg/ liter. In contrast, the MICs of all three echinocandins for C. albicans and C. krusei biofilms were relatively low (MICs < 1 mg/ liter). While echinocandins exhibited generally high MICs against C. parapsilosis biofilms, MFG exhibited the lowest MICs against these isolates (4 mg/liter). A paradoxical growth effect was observed with CAS concentrations ranging from 8 to 64 mg/ liter against C. albicans and C. parapsilosis biofilms but not against C. krusei, C. lusitaniae, or C. guilliermondii. While nonalbicans Candida planktonic cells were susceptible to all echinocandins, there were drug-and species-specific differences in susceptibility among biofilms of the various Candida species, with C. lusitaniae and C. guilliermondii exhibiting profiles of high MICs of the three echinocandins.

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Invasive candidiasis and candidemia: from current opinions to future perspectives

Cited by 31 publications

References 103 publications

Retrospective Analysis of Epidemiology and Prognostic Factors for Candidemia at a Hospital in China, 2000^|^ndash;2009

Retrospective Analysis of Epidemiology and Prognostic Factors for Candidemia at a Hospital in China, 2000^|^ndash;2009

Evaluation of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Clinically Important Yeast Species

Species-Specific and Drug-Specific Differences in Susceptibility of Candida Biofilms to Echinocandins: Characterization of Less Common Bloodstream Isolates

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