Invasive candidiasis and candidaemia in neonates and children: update on current guidelines

Tragiannidis, Athanasios; Tsoulas, Christos; Groll, Andreas H.

doi:10.1111/myc.12268

Cited by 21 publications

(16 citation statements)

References 131 publications

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“…28 The detailed data are shown in Table 5. The annual incidence of neonatal IC was higher than that of non-neonatal IC in our study, which differs from results reported by Tragiannidis et al, 29 Motta et al, 30 Some previous reports showed that C albicans was the main species responsible for invasive Candida infection (C albicans > 50%). 20,25,31,33,34 Nevertheless, recent reports, including our study, have shown that non-albicans Candida species are becoming the dominant species responsible for invasive Candida infection.…”

Section: Among Neonates With Invasivecontrasting

confidence: 99%

Epidemiology, antifungal susceptibility, risk factors and mortality of invasive candidiasis in neonates and children in a tertiary teaching hospital in Southwest China

Zeng

Tian

Ding

et al. 2020

Mycoses

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Invasive candidiasis (IC) is the most common fungal disease among hospitalised patients worldwide and is associated with high morbidity and mortality in neonates and children. 1 The incidence of IC is greater among children than among adults. 2 The main risk factors are the administration of broad-spectrum antibiotics, premature birth, very low birthweight, central venous catheter placement, parenteral nutrition administration, immunosuppression, congenital conditions and necrotising enterocolitis. 1

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Section: Among Neonates With Invasivecontrasting

confidence: 99%

Epidemiology, antifungal susceptibility, risk factors and mortality of invasive candidiasis in neonates and children in a tertiary teaching hospital in Southwest China

Zeng

Tian

Ding

et al. 2020

Mycoses

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“…Historically, the highest rates of candidemia have been recorded in neonates and infants <1 year of age . In 2000, the incidence of candidemia in the US was higher in children than in adults (43 vs 30 per 100 000 children per year) and was associated with a mean 21.1‐day increase in length of hospital stay and a mean increase of $92 266 in total per‐patient hospital charges, figures substantially higher than in hospitalised adults .…”

Section: Epidemiology Of Paediatric Candidemiamentioning

confidence: 99%

Candidemia in children: Epidemiology, prevention and management

Mantadakis

Pana

Zaoutis

2018

Mycoses

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Candidemia is the leading cause of invasive fungal infections in hospitalised children. The highest rates of candidemia have been recorded in neonates and infants <1 year of age. Candidemia is more frequent in neonates and young infants than in adults, and is associated with better clinical outcomes, but higher inpatient costs. Over the last 10 years, a declining trend has been noted in the incidence of paediatric candidemia in the US and elsewhere due to the hospital-wide implementation of central-line insertion and maintenance bundles that emphasise full sterile barrier precautions, chlorhexidine skin preparation during line insertion, meticulous site and tubing care, and daily discussion of catheter necessity. Additional interventions aiming at reducing gut-associated candidemia are required in immunocompromised and critically ill children.

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“… 8 , 9 , 10 Even though many new antifungal drugs have been discovered, the candidiasis-related mortality rate remains high, ranging from 7.7% to 26%. 11 …”

Section: Introductionmentioning

confidence: 99%

Candida Associated Bloodstream Infections in Pediatric Hematology Patients: Single Center Experience

Gökçebay

Yaralı

Işık

et al. 2016

Mediterr J Hematol Infect Dis

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Background and ObjectivesCandida-associated bloodstream infections are frequent and potentially life-threatening conditions in hematology patients. The aim of this study is to evaluate the characteristics, risk factors, and outcome of Candida-associated bloodstream infections in children with hematological diseases.MethodsThe medical records of the patients with hematological diseases and hematopoietic stem cell transplantation (HSCT) recipients who were diagnosed as Candida-associated bloodstream infection between February 2010 and February 2014 were reviewed retrospectively.ResultsThirty episodes of candidemia involving 26 patients (38% female, and 62% male) with a median age of 7-year (range; 1 to 17) were noted. The incidence of candidemia in our study was 5.2 per 1000 hospital admissions. Infections with non-albicans Candida spp. occurred more frequently (63%) and C. krusei was the predominant microorganism among non-albicans Candida spp. (37%). Candida albicans was isolated from 11 of the 30 episodes (37%). Twenty-six of the episodes (88%) patients had a central venous catheter (CVC) prior to candidemia, and they were removed in 16 (62%). Thirty-day mortality rate was 20%. Isolated Candida spp, underlying disease and its status, presence of mucositis, neutropenia, using of broad spectrum antibiotics, corticosteroids or total parenteral nutrition were not identified as predictors of outcome. Multivariate analysis revealed that CVCs kept in place was the only significant factor associated with mortality (OR, 0.07; 95% CI, 0.006–0.716).ConclusionsCandida-associated bloodstream infections were common in children with hematological diseases and HSCT recipients, particularly in patients with CVCs. In addition to appropriate antifungal therapy, CVC removal improves the outcome of candidemia in children with hematological disease.

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Invasive candidiasis and candidaemia in neonates and children: update on current guidelines

Cited by 21 publications

References 131 publications

Epidemiology, antifungal susceptibility, risk factors and mortality of invasive candidiasis in neonates and children in a tertiary teaching hospital in Southwest China

Epidemiology, antifungal susceptibility, risk factors and mortality of invasive candidiasis in neonates and children in a tertiary teaching hospital in Southwest China

Candidemia in children: Epidemiology, prevention and management

Candida Associated Bloodstream Infections in Pediatric Hematology Patients: Single Center Experience

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