Invasive Breast Cancer Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Gradishar, William J.; Anderson, Benjamin O.; Balassanian, Ronald; Blair, Sarah L.; Burstein, Harold J.; Cyr, Amy; Elias, Anthony; Farrar, William B.; Forero, Andres; Giordano, Sharon H.; Goetz, Matthew P.; Goldstein, Lori J.; Hudis, Clifford A.; Isakoff, Steven J.; Marcom, P. Kelly; Mayer, Ingrid A.; McCormick, Beryl; Moran, Meena S.; Patel, Sameer A.; Pierce, Lori J.; Reed, Elizabeth; Salerno, Kilian E.; Schwartzberg, Lee S.; Smith, Karen L.; Smith, Mary Lou; Soliman, Hatem; Somlo, George; Telli, Melinda L.; Ward, John H.; Shead, Dorothy A.; Kumar, Rashmi

doi:10.6004/jnccn.2016.0037

Cited by 287 publications

(279 citation statements)

References 87 publications

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“…For some cancers, such as breast cancer and colorectal cancer, the association between the greater number of harvested LN and favorable survival has been established; thus, minimal number of dissected LNs is recommended for accurate staging (18,19). Although the current NCCN guidelines for NSCLC don't recommend the minimal number of harvests LN, Dr. Liang et al analyzed the US SEER data and a Chinese multi-institutional registry and found that a greater number of harvested LN was associated with more-accurate node staging and better long-term survival.…”

Section: Discussionmentioning

confidence: 99%

Appropriate lymphadenectomy significantly reduced recurrence after segmentectomy for patients with non-small cell lung cancer

Wang¹,

Gu²,

Pan³

et al. 2018

J. Thorac. Dis.

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Background: Segmentectomy has been widely used for small-sized non-small cell lung cancer (NSCLC).The objective of this study is to determine the impact of number of harvested lymph nodes (LNs) on survival for patients undergoing segmentectomy. Methods: The clinicopathologic data of patients undergoing segmentectomy for NSCLC from July 2011 to December 2014 were retrospectively analyzed. Survival analysis was performed by Kaplan-Meier method and Cox regression analysis. Results: A total of 259 patients with NSCLC were eligible for analysis. Patients with harvested LN ≥6 had higher frequency of nodal metastasis in pathologic examination (9.4% vs. 1.5%, P=0.005). The 3-year recurrence-free survival (RFS) of patients with harvested LN ≥6 (90.2%) was significantly higher than that of patients with harvested LN <6 (73.7%, log-rank P=0.038). Multivariable Cox analysis identified harvested LN ≥6 as an independent predictor for improved RFS [hazard ratio (HR) =0.35; 95% confidence interval (CI): 0.14-0.90; P=0.029]. There was no significant difference in RFS between patients with harvested LN station ≥3 and <3 (log-rank P=0.34). Conclusions: The number of harvest LN ≥6 was independently associated with improved RFS for NSCLC patients undergoing segmentectomy, supporting the National Comprehensive Cancer Network (NCCN) guidelines of appropriate LN sampling.

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Section: Discussionmentioning

confidence: 99%

Appropriate lymphadenectomy significantly reduced recurrence after segmentectomy for patients with non-small cell lung cancer

Wang¹,

Gu²,

Pan³

et al. 2018

J. Thorac. Dis.

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“…The 5-year results of the trial changed practice, albeit modestly [18] and the National Comprehensive Cancer Network guidelines [19] allow BCS±WBRT in women ≥70 years with clinical stage 1 hormone receptor positive EBC. The PRIME 2 trial [20] randomized 1326 women ≥65 years with T1, T2 (≤3cm), pN0 tumours to 5-year adjuvant endocrine therapy (ET) ±WBRT.…”

Section: Role Of Radiotherapy (Rt) After Breast Conservative Surgmentioning

confidence: 99%

Controversial issues in the management of older adults with early breast cancer

Mislang

Cheung

Hamaker

et al. 2017

Journal of Geriatric Oncology

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It is well recognized that the incidence of breast cancer increases significantly with age.Despite this, older people remain under-represented in many clinical trials and their management relies on extrapolation of data from younger patients. Providing an aggressive intervention can be challenging, particularly in less fit older patients where a conservative approach is commonly perceived to be more appropriate. The optimal management of this population is unknown and treatment decision should be personalized. This review article will discuss several controversial issues in managing older adults with early breast cancer in a multidisciplinary setting, including the role of surgical treatment of the axilla in clinically node negative disease, radiotherapy after breast conservation surgery in low-risk tumors, personalizing adjuvant systemic therapy, and geriatric assessments in breast cancer treatment decisions.

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“…[6,7] International guidelines confirm that 1 year of trastuzumab remains the standard of care as part of an adjuvant therapy regimen for patients with HER2-positive early breast cancer. [8][9][10] We note the following specific issues in relation to the commentary: 1. Parameters used in the number needed to treat (NNT) calculation:…”

Section: Cost Considerations In Determining the Affordability Of Adjumentioning

confidence: 99%

Cost considerations in determining the affordability of adjuvant trastuzumab in breast cancer

Sereda¹,

Abratt²

2016

S Afr Med J

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Invasive Breast Cancer Version 1.2016, NCCN Clinical Practice Guidelines in Oncology

Cited by 287 publications

References 87 publications

Appropriate lymphadenectomy significantly reduced recurrence after segmentectomy for patients with non-small cell lung cancer

Appropriate lymphadenectomy significantly reduced recurrence after segmentectomy for patients with non-small cell lung cancer

Controversial issues in the management of older adults with early breast cancer

Cost considerations in determining the affordability of adjuvant trastuzumab in breast cancer

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