Invasive breast cancer: mammographic measurement.

Flanagan, Fidelma; McDermott, Miranda; Barton, Premsri; Pilgram, T K; Dehdashti, Farrokh; Wick, Mark R.; Monsees, Barbara

doi:10.1148/radiology.199.3.8638011

Cited by 36 publications

(14 citation statements)

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“…The choice of projection was based on where the tumour mass was most clearly discerned. In cases of spiculated lesions the nucleus of the tumour was measured (13) .…”

Section: Growth Rate Estimationmentioning

confidence: 99%

Estimates of Breast Cancer Growth Rate From Mammograms and Its Relation to Tumour Characteristics

Förnvik

Lång

Andersson

et al. 2015

Radiat Prot Dosimetry

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“…The choice of projection was based on where the tumour mass was most clearly discerned. In cases of spiculated lesions the nucleus of the tumour was measured (13) .…”

Section: Growth Rate Estimationmentioning

confidence: 99%

Estimates of Breast Cancer Growth Rate From Mammograms and Its Relation to Tumour Characteristics

Förnvik

Lång

Andersson

et al. 2015

Radiat Prot Dosimetry

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“…When the pathologic results of the lesion obtained from the DVAR demonstrated carcinoma, determination of tumor size to establish a treatment plan was more difficult. However, measurements of tumor size are also inaccurate in carcinomas that have been partially excised during surgical biopsy [28]. Moreover, with pre-DVAR sonography, the size of infiltrating carcinomas can also be evaluated [29,30].…”

Section: Us-guided Dvarmentioning

confidence: 99%

Breast lesions with imaging-histologic discordance during US-guided 14G automated core biopsy: can the directional vacuum-assisted removal replace the surgical excision? Initial findings

et al. 2007

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The purpose of this study was to determine the frequency of carcinoma at percutaneous directional vacuum-assisted removal (DVAR) in women with imaging-histologic discordance during ultrasound (US)-guided automated core needle biopsy, and to determine the role of DVAR in breast lesions with imaging-histologic discordance. A US-guided 14-gauge automated core needle biopsy was performed on 837 consecutive lesions. Imaging-histologic discordance was prospectively considered in 33 of 634 benign biopsies. DVAR was recommended in those lesions. Among the 33 lesions, 26 lesions that underwent subsequent DVAR or surgical excision made up our study population. Medical records, imaging studies, and histologic findings were reviewed. Among the 26 lesions, 18 lesions underwent subsequent US-guided DVAR, with 8-gauge probes for 15 of the lesions, and 11-gauge for three of the lesions. Two lesions were diagnosed as having carcinoma (2/18, 11.1% of upgrade rate; 3.1-32.8% CI). The remaining eight lesions underwent subsequent surgical excision, and carcinoma was diagnosed in one case (12.5% of upgrade rate; 2.2-47.1% CI). A US-guided DVAR of the breast mass with imaging-histologic discordance during US-guided 14-gauge automated core needle biopsy is a valuable alternative to surgery as a means of obtaining a definitive histological diagnosis.

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“…Reactive changes of the subcutaneous tissue secondary to the tumour may also be misconstrued as tumour by the palpating hand [7]. Other factors that affect clinical palpation include obesity [9].…”

Section: Discussionmentioning

confidence: 99%

“…The pathologist also has to slice the tumour according to the longest dimension based on palpation of the tumour. Thus, the longest dimension may not always be included in a slice and achieving it may be even more difficult when the margins are ill-defined [5,9]. Other possible causes of error are shrinkage of the tumour during formalin fixation and paraffin embedding [5].…”

Section: Discussionmentioning

confidence: 99%

“…Clinical staging aided by imaging drives the decision for mastectomy or breast conserving surgery, both of which are significant life-changing procedures for the patient. Since the 1990s research has been addressing the issue of which imaging modality correlates best with pathological size (Table 1) [4][5][6][7][8][9][10][11][12][13][14][15][16][17]. These studies variably assessed size via clinical, ultrasound, mammogram and pathological examination.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Multimodal assessment of mammogram, ultrasound and clinical palpation in relation to pathological size of breast carcinoma

Fadzli¹,

Rahmat²,

MN³

et al. 2018

Integr Cancer Sci Therap

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Objectives: Ultrasonography, mammography and clinical examination (conventional triple assessment modalities) are compared to the gold standard of pathological size to assess their accuracy in measuring size of palpable breast cancer lesions. This knowledge has an important role in the patient's further management: for staging, choice of surgical technique and prognostication.Patients and methods: 71 tumours were studied in 70 patients who were prospectively collected over a 2 year period. Pearson's correlation test and Bland-Altman's plot were used to analyse tumour size by clinical palpation, ultrasound and mammogram.Results: Histopathological examination revealed 60 invasive carcinomas (58 ductal type, 2 lobular type), 4 ductal carcinoma in situ, 2 mixed and 5 special types. The pathological size varied from 0.5cm to 9.5cm. Ultrasound had the best correlation with pathological size, with r= 0.845 (p< 0.001), but with a tendency to underestimate. Size correlation for mammogram and clinical palpation were similar and statistically significant. However, the standard deviation of mammographic size was more compared to size on clinical examination (1.3 (mammogram) vs. 2.2 (clinical)). Clinical palpation was inclined to overestimate, whereas mammogram neither over-nor under-estimated size. Measurements using ultrasonography produced the lowest standard deviation, thus a lower variability from the mean. Conclusion:This study demonstrated that ultrasound is the more accurate modality compared to mammogram and clinical palpation size for the measurement of palpable breast cancer lesions. However, ultrasound may downstage tumours due to its tendency to underestimate size.

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Invasive breast cancer: mammographic measurement.

Abstract: Mammography can allow tumor size to be measured accurately and can be used as an alternative when pathologic staging is not possible.

Cited by 36 publications

References 0 publications

Estimates of Breast Cancer Growth Rate From Mammograms and Its Relation to Tumour Characteristics

Estimates of Breast Cancer Growth Rate From Mammograms and Its Relation to Tumour Characteristics

Breast lesions with imaging-histologic discordance during US-guided 14G automated core biopsy: can the directional vacuum-assisted removal replace the surgical excision? Initial findings

Multimodal assessment of mammogram, ultrasound and clinical palpation in relation to pathological size of breast carcinoma

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