Invasive Aspergillus flavus sinusitis in an immunocompetent patient using intranasal cocaine

Progression of chronic rhinosinusitis to invasive cerebro-orbital aspergillosis following steroid treatment: A case of induced immunosuppression

“…Invasive fungal rhinosinusitis in an immunocompetent patient is often related to certain predisposing risk factors. These can range from malaria [12] or diabetes [13] , to intranasal drug use [7] . Given that this patient did not have such history, this case may represent a rare but previously observed complication of chronic steroid treatment [13] .…”

“…However, it may sometimes develop into invasive infection, commonly in immunocompromised individuals [3] , [4] . Recently, there has been a substantial increase in the number of reported acute invasive fungal infections in immunocompetent individuals [3] , [5] , [6] , [7] , [8] , [9] , [10] , [11] . We present a case of an immunocompetent young adult initially presenting with CRSwNP who then developed invasive aspergillosis with cerebral and orbital involvement.…”