Invasive aspergillosis in patients with severe alcoholic hepatitis

Gustot, Thierry; Maillart, Evelyne; Bocci, Massimo; Surin, Rudy; Trépo, Eric; Degré, Delphine; Lucidi, Valério; Taccone, Fabio Silvio; Delforge, Marie-Luce; Vincent, Jean‐Louis; Donckier, Vincent; Jacobs, Frédérique; Moreno, Christophe

doi:10.1016/j.jhep.2013.09.011

Cited by 119 publications

(141 citation statements)

References 26 publications

(30 reference statements)

Supporting

Mentioning

137

Contrasting

Unclassified

Order By: Relevance

“…[16] Opportunistic and fungal infections have been described in patients with AH and were also present in our cohort, indicating impaired host defense. [15,18,19] A multivariate analysis revealed that fungal infections were strongly associated with mortality in AH patients (OR 9.97, p ¼ 0.014), which indicates the need for antimycotic treatment strategies in complicated AH.…”

Section: Discussionmentioning

confidence: 99%

“…In decompensated liver, cirrhosis and acute-on-chronic liver failure, infection sites, and pathogens were studied in detail and antibiotic strategies have been established for their complications. [8][9][10][11][12][13][14] In contrast, although several studies have shown that patients with AH are also at increased risk for complicating infections, [4,[15][16][17] neither pathogen patterns, nor antibiotic treatment strategies have been identified for AH. Current standard therapy with corticosteroids may further increase the risk for infections, [5] emphasizing the demand for a better knowledge of microbiology in AH.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Infections complicating severe alcoholic hepatitis:Enterococcusspecies represent the most frequently identified pathogen

Beisel

Blessin²,

Wiesch

et al. 2016

Scandinavian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Infections complicating severe alcoholic hepatitis:Enterococcusspecies represent the most frequently identified pathogen

Beisel

Blessin²,

Wiesch

et al. 2016

Scandinavian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…Overall (listing the types of infections from most to least frequent), cirrhotic patients are prone to develop SBP, urinary tract infections, pneumonia, bacteremia, and skin/soft tissue infections [70]. In the ICU, pneumonia represents the most common septic trigger observed in association with liver cirrhosis; here, fungal infections represent a particularly life-threatening scenario [67,68,71]. Infection and pathogen surveillance programs identified gram-positive cocci as the most likely cause of nosocomial infections in association with invasive diagnostic and/or therapeutic procedures [67][68][69].…”

Section: Infection And/or Sepsismentioning

confidence: 99%

“…Infection and pathogen surveillance programs identified gram-positive cocci as the most likely cause of nosocomial infections in association with invasive diagnostic and/or therapeutic procedures [67][68][69]. In contrast, gram-negative bacilli are responsible for approximately 60% of all community-acquired infections [67,68,71]. During the past 10 years, prevalence of nosocomial infections involving multiresistant bacteria has increased from 10% to 20-25%.…”

Section: Infection And/or Sepsismentioning

confidence: 99%

Intensive Care Therapy for Patients with Advanced Liver Diseases

Katsounas

Canbay

2018

Visc Med

View full text Add to dashboard Cite

Decompensated cirrhosis is characterized by high hospitalization rates and costs, frequent readmissions, and poor short-term survival. Patients admitted to the hospital with acute variceal bleeding and/or hepatic encephalopathy and/or renal dysfunction are at serious risk for developing infection and/or sepsis; in turn, this renders them highly susceptible to the development of multi-system organ failure. The lack of standardized intensive care unit management protocols in patients with cirrhosis along with only few data reports from longitudinal clinical trials makes it difficult for hepatologists and critical care specialists to provide uniform evidence for clinical practice that could safely consolidate favorable outcomes such as lower hospitalization rates and/or mortality. Based on a rigorous online search of the scientific literature as well as a longtime clinical experience of the authors in the field of hepatology and critical care medicine, this work represents a focused effort to elucidate the specific bio-morbidity of advanced liver diseases in relation to the aforementioned challenges in clinical management. Further meta-analyses and/or systematic reviews are needed to enable clinicians to develop more effective strategies to bridge patients with decompensated liver disease to recompensation or liver transplantation.

show abstract

“…The human intestine can serve as a source of systemic fungal products or fungal infection when the gut barrier is disrupted (11). Patients with cirrhosis frequently either are exposed to fungal products (12) or develop fungal infections, with high mortality (13)(14)(15). Spontaneous fungal peritonitis is mainly caused by Candida species -in particular by Candida albicans in patients with cirrhosis (16).…”

Section: Introductionmentioning

confidence: 99%