Invasive aspergillosis in near drowning nonneutropenic patient

Munta, Kartik; Gopal, Palepu; Vigg, Ajit

doi:10.4103/0972-5229.171413

Cited by 8 publications

(3 citation statements)

References 17 publications

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“…[ 6 7 ] There have been reports of invasive aspergillosis due to accidental drowning and necrosis of the spinal cord due to disseminated aspergillosis. [ 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

Invasive mediastinal Aspergillosis in immunocompetent male with invasion of left atrium and hilar structures

Munta

Kanala

Sunilnadikuda

et al. 2017

Indian Journal of Critical Care Medicine

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Aspergillus is described as mould characterised by septate hyphae about 2-4μ in diameter, it is ubiquitous in nature and spreads by inhalation of spores. It causes opportunistic infections in almost six forms namely Allergic bronchopulmonary aspergillosis, Aspergillus sinusitis, Cutaneous aspergillosis, Aspergilloma, Chronic pulmonary aspergillosis, Invasive aspergillosis. Invasive aspergillosis of mediastinum in an immunocompetent patient has rarely been reported. We present a case of a young male who had presented with chest pain, cough and breathleness was later diagnosed as fulminant mediastinal aspergillosis. Incisional biopsy with histology report and endotracheal cultures helped in diagnosing mediastinal aspergillosis. Despite initiation of the right antifungal therapy and best supportive measures, patient died of septic shock and multiorgan dysfunction. This case report highlights the need for higher suspicion in such cases of mediastinal masses and early tissue biopsy which can help in reducing mortality.

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“…[ 6 7 ] There have been reports of invasive aspergillosis due to accidental drowning and necrosis of the spinal cord due to disseminated aspergillosis. [ 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

Invasive mediastinal Aspergillosis in immunocompetent male with invasion of left atrium and hilar structures

Munta

Kanala

Sunilnadikuda

et al. 2017

Indian Journal of Critical Care Medicine

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show abstract

“…Alveolar diseases are characterized by the formation of solids or liquids in the alveolus, which is usually filled with air. The “increased shade” findings are observed via chest imaging ( 18 ). Suppose that this physiological phenomenon can be maintained under a microscope and the degree of shading can be quantified.…”

Section: Technological Considerationsmentioning

confidence: 99%

Lung Organoid on a Chip: A New Ensemble Model for Preclinical Studies

Kim,

Park,

Jeong

et al. 2023

Int J Stem Cells

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The lung is a complex organ comprising a branched airway that connects the large airway and millions of terminal gas-exchange units. Traditional pulmonary biomedical research by using cell line model system have limitations such as lack of cellular heterogeneity, animal models also have limitations including ethical concern, race-to-race variations, and physiological differences found in vivo . Organoids and on-a-chip models offer viable solutions for these issues. Organoids are three-dimensional, self-organized construct composed of numerous cells derived from stem cells cultured with growth factors required for the maintenance of stem cells. On-a-chip models are biomimetic microsystems which are able to customize to use microfluidic systems to simulate blood flow in blood channels or vacuum to simulate human breathing. This review summarizes the key components and previous biomedical studies conducted on lung organoids and lung-on-a-chip models, and introduces potential future applications. Considering the importance and benefits of these model systems, we believe that the system will offer better platform to biomedical researchers on pulmonary diseases, such as emerging viral infection, progressive fibrotic pulmonary diseases, or primary or metastatic lung cancer.

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“…Rare cases of invasive aspergillosis have been described in immunocompetent individuals after non-fatal drowning. [1][2][3][4][5][6] Given the diagnostic difficulties and rapidly progressive nature of this disease, the mortality rate is high at 50%. 1 Here we report a fatal case of invasive aspergillosis with pulmonary embolism after non-fatal drowning.…”

Section: Introductionmentioning

confidence: 99%

<p>Invasive Aspergillosis After Non-Fatal Drowning</p>

Koide

Hadano

Mizuochi

et al. 2020

IMCRJ

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Background: Pneumonitis and pneumonia after non-fatal drowning are common and the pathogens involved are numerous. However, invasive aspergillosis after non-fatal drowning in immunocompetent individuals is relatively rare. Here, we report a case of invasive aspergillosis complicated by pulmonary embolism after non-fatal drowning that proved fatal. Case Presentation: A 75-year-old Japanese man accidentally fell into a creek and was brought to a local hospital. His oxygenation steadily deteriorated to the point that he required intubation and mechanical ventilation. He was then transferred to the emergency department at our hospital. On arrival, he had severe respiratory dysfunction with diminished breath sounds. Radiography of the chest and computed tomography of the lungs showed diffuse bilateral infiltrates. The diagnosis was acute respiratory distress syndrome caused by aspiration pneumonitis as a result of non-fatal drowning and septic shock. Despite intensive care, the patient's hypoxia continued to worsen and he died on day 7. Computed tomography scans obtained at autopsy showed that both lungs were extensively infiltrated with effusion. An embolus was also detected in the right pulmonary artery. Microscopic analysis revealed diffuse filamentous fungi throughout the lungs, heart, stomach, thyroid gland, and the pulmonary embolus, which were identified as Aspergillus fumigatus by culture. Conclusion: Invasive aspergillosis should also be considered in immunocompetent patients with severe respiratory failure after non-fatal drowning who do not respond to broad-spectrum antibiotics. Angioinvasive aspergillosis can even result in fatal pulmonary embolism; hence, early targeted testing for Aspergillus species and empiric intravenous voriconazole should be considered in such cases.

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Invasive aspergillosis in near drowning nonneutropenic patient

Cited by 8 publications

References 17 publications

Invasive mediastinal Aspergillosis in immunocompetent male with invasion of left atrium and hilar structures

Invasive mediastinal Aspergillosis in immunocompetent male with invasion of left atrium and hilar structures

Lung Organoid on a Chip: A New Ensemble Model for Preclinical Studies

<p>Invasive Aspergillosis After Non-Fatal Drowning</p>

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