Invasive and non-invasive Helicobacter pylori diagnostic methods in Iran

Alihosseini, Samin; Jaberinezhad, Mehran; SadeghpourHeravi, Fatemah; Ghotaslou, Reza

doi:10.1016/j.genrep.2020.100749

Cited by 3 publications

(12 citation statements)

References 35 publications

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“…It is considered the gold standard for the direct diagnosis of H. pylori . However, the accuracy of this diagnostic method depends on the load of microorganisms in the sample and the site of the gastric mucosa in which the biopsy was collected [ 14 , 25 ]. Histological diagnosis is generally confirmed through four biopsies (two from the curves and two from the body of the stomach) [ 1 ].…”

Section: Methods For Detecting H Pylorimentioning

confidence: 99%

“…Serological tests are mainly based on the estimation of antibodies against H. pylori . Specific IgG, IgA, and IgM can be measured in screening for H. pylori infection, and IgG shows more reliable results [ 14 ]. In this method, antibodies against H. pylori are detected by ELISA, immunoblotting, and enzyme immunoassays requiring the use of serum, saliva, or urine [ 16 , 41 ].…”

Section: Methods For Detecting H Pylorimentioning

confidence: 99%

“…An accurate diagnosis of H. pylori infection is the first step toward successful treatment of the patient with this infection [ 16 ]. For accurate diagnosis of this infection, the ideal is not only to use noninvasive methods but also to use invasive tests [ 14 ]. This review aims to explore invasive and noninvasive diagnostic tests for diagnosing H. pylori infection.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Methods for <i>Helicobacter pylori</i>

Costa,

das Graças Carvalho,

La Guárdia Custódio Pereira

et al. 2024

Med Princ Pract

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H. pylori infection is a significant global health concern. It cannot be diagnosed based solely on the patient's medical history and symptoms, and laboratory and imaging tests are often required to confirm the diagnosis. Both non-invasive and invasive methods are available for diagnosing H. pylori infection, including conventional and advanced detection techniques. It is not uncommon for patients to present with false-negative results due to the use of inadequate investigation methodologies, which prevents the adoption of appropriate clinical management. Thus, an analysis of the literature regarding the methods of diagnosis of H. pylori, with its advantages and disadvantages, is necessary. Publications in specialized scientific journals will undoubtedly contribute to facilitating access by professionals interested in the topic providing greater knowledge and potentially clinically useful guidance. In this review, the authors have sought to analyze and summarize the invasive and non-invasive methods, their applications, limitations, and the conditions that affect the sensitivity of the tests used for diagnosing H. pylori, an essential step for the successful treatment of this infection. It is essential to treat all patients infected with H. pylori. This represents a significant change in the approach, as previously treatment was recommended only for patients showing symptoms of infection. Therefore, it is crucial to understand the limitations of traditional diagnostic methods and help raise awareness among healthcare professionals about the latest advances in diagnosing this important bacterium.

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Section: Methods For Detecting H Pylorimentioning

confidence: 99%

Section: Methods For Detecting H Pylorimentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Methods for <i>Helicobacter pylori</i>

Costa,

das Graças Carvalho,

La Guárdia Custódio Pereira

et al. 2024

Med Princ Pract

View full text Add to dashboard Cite

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“…However, the NPs were not able to block the attachment of H. pylori to gastric epithelial cells (Figure 4E). The clinical diagnosis of H. pylori infection is conventionally performed by tests, such as the rapid urease test (RUT), [146,147] serological tests, [148,149] invasive endoscopy, [150,151] and stool [145] Copyright 2018, Springer Nature. antigen test (SAT).…”

Section: Ddss Based On Nanotechnologymentioning

confidence: 99%

“…The clinical diagnosis of H. pylori infection is conventionally performed by tests, such as the rapid urease test (RUT), [ 146,147 ] serological tests, [ 148,149 ] invasive endoscopy, [ 150,151 ] and stool antigen test (SAT). [ 152,153 ] However, some drawbacks of these tests have been reported, such as limitations in young children and pregnant women (related to UBT: 14 C‐urea breath test), [ 154,155 ] low sensitivity and acceptability (related to serum antibody test and invasive endoscopy), [ 156 ] appearance of false negative results in low bacterial infections (related to SAT).…”

Section: Drug Delivery Systems (Ddss) In the Fight Against H Pylorimentioning

confidence: 99%

Future Nanotechnology‐Based Strategies for Improved Management of Helicobacter pylori Infection

Kamankesh,

Yadegar,

Llopis‐Lorente

et al. 2023

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Helicobacter pylori (H. pylori) is a recalcitrant pathogen, which can cause gastric disorders. During the past decades, polypharmacy‐based regimens, such as triple and quadruple therapies have been widely used against H. pylori. However, polyantibiotic therapies can disturb the host gastric/gut microbiota and lead to antibiotic resistance. Thus, simpler but more effective approaches should be developed. Here, some recent advances in nanostructured drug delivery systems to treat H. pylori infection are summarized. Also, for the first time, a drug release paradigm is proposed to prevent H. pylori antibiotic resistance along with an IVIVC model in order to connect the drug release profile with a reduction in bacterial colony counts. Then, local delivery systems including mucoadhesive, mucopenetrating, and cytoadhesive nanobiomaterials are discussed in the battle against H. pylori infection. Afterward, engineered delivery platforms including polymer‐coated nanoemulsions and polymer‐coated nanoliposomes are poposed. These bioinspired platforms can contain an antimicrobial agent enclosed within smart multifunctional nanoformulations. These bioplatforms can prevent the development of antibiotic resistance, as well as specifically killing H. pylori with no or only slight negative effects on the host gastrointestinal microbiota. Finally, the essential checkpoints that should be passed to confirm the potential effectiveness of anti‐H. pylori nanosystems are discussed.

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