Invasion of the Splenic Artery Is a Crucial Prognostic Factor in Carcinoma of the Body and Tail of the Pancreas

Kanda, Mitsuro; Fujii, Tsutomu; Sahin, Tevfik Tolga; Kanzaki, Akiyuki; Nagai, Shunji; Yamada, Suguru; Sugimoto, Hiroyuki; Nomoto, Shuji; Takeda, Shin; Kodera, Yasuhiro; Morita, Satoshi; Nakao, Akimasa

doi:10.1097/sla.0b013e3181cf9171

Cited by 67 publications

(55 citation statements)

References 25 publications

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“…20/29 (68.97%) patients with cancer in the pancreatic body or tail were CTC subtype-positive while merely 31/66 (46.97%) patients with cancer in the pancreatic head or neck were CTC subtype-positive. This may be caused by the different serving vessels for different locations of pancreatic cancer [34]. Vascular invasion from the pancreatic head or neck cancer generally infiltrates the portal/superior mesenteric vein.…”

Section: Discussionmentioning

confidence: 99%

Circulating Tumor Cells as a Biomarker in Pancreatic Ductal Adenocarcinoma

Liang

Sun

Wang

et al. 2017

Cell Physiol Biochem

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Background/Aims: Circulating tumor cells (CTCs) are valuable in both basic research and clinical application for cancer management. In the current study, we evaluated the diagnostic value of CTCs in pancreatic ductal adenocarcinoma (PDAC). Methods: In total, 143 blood samples from 95 consecutively diagnosed PDAC patients and 48 healthy donors were collected. Combined data from immunostaining of CD45, DAPI and fluorescence in situ hybridization (FISH) with chromosome 8 centromere (CEP8) probe were used to identify CTCs. Cells with features of CD45-/DAPI+/CEP8>2 were detected as CTCs. Results: CTCs were classified as triploid, tetraploid and multiploid based on chromosome 8 copy number. CTC subtype composition was significantly different among groups. Both subtype number and total CTC number were significantly increased in PDAC patients, compared to healthy controls. Total CTC number had 75.8% sensitivity and 68.7% specificity at a cutoff value of 2 cells/3.2 mL. This study is the first to report that CTC subtype number is also useful in cancer diagnosis. Sensitivity was 53.7% and specificity was 85.4% at a cutoff point of 2 CTC subtypes. The diagnostic value of both total CTC number and CTC subtype number was a little poorer than CA199. Conclusions: Both CTC subtype and total CTC number may serve as potential biomarkers for PDAC.

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Section: Discussionmentioning

confidence: 99%

Circulating Tumor Cells as a Biomarker in Pancreatic Ductal Adenocarcinoma

Liang

Sun

Wang

et al. 2017

Cell Physiol Biochem

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“…14 of the remaining 35 studies (Kim et al, 2006;Murakami et al, 2008;Balentine et al, 2010;Chu et al, 2010;Kanda et al, 2010;de Jong et al, 2011;Jamieson et al, 2011;Kneuertz et al, 2011;Maithel et al, 2011;Singal et al, 2011;Chatterjee et al, 2012;Watanabe et al, 2012;Xie et al, 2012;Fisher et al, 2013) were excluded because they were reported by the same institutions as other studies. 21 studies (Ozaki et al, 1999;Mitsunaga et al, 2005;Nakagohri et al, 2006;Pawlik et al, 2007;Kazanjian et al, 2008;Kato et al, 2009;Nagai et al, 2009;Sergeant et al, 2009;Ben et al, 2010;Murakami et al, 2010;Bachellier et al, 2011;Kim et al, 2011;Schiffman et al, 2011;Cheng et al, 2012;Jamieson et al, 2012;Lee et al, 2012;Murata et al, 2012;Sahin et al, 2012;Takahashi et al, 2012;Turrini et al, 2013;Xie et al, 2013) were included in the final meta-analysis, comprising one case matched controlled study and 20 retrospective cohort studies (Table 1).…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Influence of Perineural Invasion on Survival and Recurrence in Patients with Resected Pancreatic Cancer

Zhang¹,

Hua²,

Sun³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…It needs to be mentioned that there are no larger patient series on arterial resections in pancreatic surgery. Therefore, this procedure can be carried out safely in experienced hands, but is not based on highquality scientific data and outcome studies so far [14][15][16].…”

Section: Arterial Resectionsmentioning

confidence: 99%