Invasion of Salmonella enteritidis in avian intestinal epithelial cells in vitro is influenced by short-chain fatty acids

Immerseel, Filip Van; Buck, Jeroen De; Pasmans, Frank; Velge, P.; Bottreau, Elisabeth; Fievez, Veerle; Haesebrouck, Freddy; Ducatelle, Richard

doi:10.1016/s0168-1605(02)00542-1

Cited by 132 publications

(114 citation statements)

References 28 publications

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“…Similar findings were reported in response to oral supplementation of sodium butyrate or butyric acid that reduced the colonisation and shedding of S. enteritidis in broilers (Van Immerseel et al, 2005;Fernandez-Rubio et al, 2009). These findings may have arisen either due to the direct antibacterial activity of butyric acid (Van Immerseel et al, 2003) or due to the decreased invasiveness of Salmonella spp. (possibly due to the downregulation of genes in SPI1) through intestinal epithelium (Van Immerseel et al, 2003;Gantois et al, 2006).…”

Section: Immunitymentioning

confidence: 99%

“…These findings may have arisen either due to the direct antibacterial activity of butyric acid (Van Immerseel et al, 2003) or due to the decreased invasiveness of Salmonella spp. (possibly due to the downregulation of genes in SPI1) through intestinal epithelium (Van Immerseel et al, 2003;Gantois et al, 2006). Sodium butyrate can inhibit the nitric oxide production and expression of cytokines such as IL-1β, IL-6, IFN-γ, and IL-10 in chicken macrophage cells stimulated by the presence of S. typhimurium lipopolysaccharides (Zhou et al, 2014).…”

Section: Immunitymentioning

confidence: 99%

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Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity

Ahsan

Cengiz

Raza

et al. 2016

World's Poultry Science Journal

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The effect of sodium butyrate on various bodily parameters of broilers such as performance, gut microflora, gut morphology, and immunity is reviewed in order to highlight its importance as an alternative to antibiotic growth promoters. Sodium butyrate is used as a source of butyric acid, which is known for its beneficial effects in the gut in monogastrics. Sodium butyrate is available in uncoated and entericcoated forms protected with fat or fatty acid salts. Varying results in productive performance, gut microbes, and gut morphology have been reported in the literature in response to supplementation of broiler diets with uncoated and fatcoated types of sodium butyrate. However, sodium butyrate has shown pronounced effects on immunity of chickens that are not fully understood yet. Although there are contrasting results of sodium butyrate in chicken, further research is needed using the sodium butyrate coated with the salts of fatty acids.

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Section: Immunitymentioning

confidence: 99%

Section: Immunitymentioning

confidence: 99%

Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity

Ahsan

Cengiz

Raza

et al. 2016

World's Poultry Science Journal

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“…This effect is dependent upon the transcriptional regulator HilD, which is posttranslationally modified by propionyl-CoA [62]. Furthermore, pre-incubation of S. enteritidis with propionate and butyrate resulted in decreased epithelial cell invasion [63]. Moving to a whole-animal infection model (pigs), supplementation of the diet with a mixture of organic acids including propionate resulted in decreased Salmonella recovery from the mesenteric lymph nodes [64].…”

Section: Propionate Metabolism As An Antimicrobial Targetmentioning

confidence: 99%

Loving the poison: the methylcitrate cycle and bacterial pathogenesis

et al. 2018

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Propionate is an abundant catabolite in nature and represents a rich potential source of carbon for the organisms that can utilize it. However, propionate and propionate-derived catabolites are also toxic to cells, so propionate catabolism can alternatively be viewed as a detoxification mechanism. In this review, we summarize recent progress made in understanding how prokaryotes catabolize propionic acid, how these pathways are regulated and how they might be exploited to develop novel antibacterial interventions.

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“…This relationship may be evidenced by the limited genetic diversity observed among S. Enteritidis strains based on random amplified polymorphic DNA plasmid profiling and phage typing (257). Work with laying hens suggested that because S. Enteritidis infects reproductive tissues, namely, the oviduct and ovaries, these tissues represent critical avenues for egg contamination; additionally, this serovar may also have evolved the means to survive the hostile environment of internal egg contents (252,(258)(259)(260)(261)(262)(263)(264)(265)(266)(267).…”

Section: The Salmonella-chicken Host Interactionmentioning

confidence: 99%

Salmonella Pathogenicity and Host Adaptation in Chicken-Associated Serovars

Foley

Johnson

Ricke

et al. 2013

Microbiol Mol Biol Rev

263

218

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SUMMARY Enteric pathogens such as Salmonella enterica cause significant morbidity and mortality. S. enterica serovars are a diverse group of pathogens that have evolved to survive in a wide range of environments and across multiple hosts. S. enterica serovars such as S . Typhi, S . Dublin, and S . Gallinarum have a restricted host range, in which they are typically associated with one or a few host species, while S . Enteritidis and S . Typhimurium have broad host ranges. This review examines how S. enterica has evolved through adaptation to different host environments, especially as related to the chicken host, and continues to be an important human pathogen. Several factors impact host range, and these include the acquisition of genes via horizontal gene transfer with plasmids, transposons, and phages, which can potentially expand host range, and the loss of genes or their function, which would reduce the range of hosts that the organism can infect. S . Gallinarum, with a limited host range, has a large number of pseudogenes in its genome compared to broader-host-range serovars. S. enterica serovars such as S . Kentucky and S . Heidelberg also often have plasmids that may help them colonize poultry more efficiently. The ability to colonize different hosts also involves interactions with the host's immune system and commensal organisms that are present. Thus, the factors that impact the ability of Salmonella to colonize a particular host species, such as chickens, are complex and multifactorial, involving the host, the pathogen, and extrinsic pressures. It is the interplay of these factors which leads to the differences in host ranges that we observe today.

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Invasion of Salmonella enteritidis in avian intestinal epithelial cells in vitro is influenced by short-chain fatty acids

Cited by 132 publications

References 28 publications

Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity

Sodium butyrate in chicken nutrition: the dynamics of performance, gut microbiota, gut morphology, and immunity

Loving the poison: the methylcitrate cycle and bacterial pathogenesis

Salmonella Pathogenicity and Host Adaptation in Chicken-Associated Serovars

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