Invasion of blood vessels as significant prognostic factor in radically resected T1-3N0M0 non-small-cell lung cancer

Gabor, Sabine; Renner, Heiko; Popper, Helmut; Anegg, Udo; Sankin, Oliver; Matzi, Veronika; Lindenmann, Jörg; Jüttner, F.-M.

doi:10.1016/j.ejcts.2003.11.033

Cited by 79 publications

(66 citation statements)

References 10 publications

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“…Furthermore vascular invasion, along with other published studies [25][26][27][28], in our large series resulted as another strong independent prognostic factor. Although prospective studies are needed, our findings underline the importance of a careful evaluation of lymph nodes and vascular invasion in resected NSCLC as it may provide additional useful information for identifying patients who are at high risk and who may be candidates for further medical treatment after or before surgery.…”

Section: Discussionsupporting

confidence: 78%

“…Naito et al [26] Gabor et al [27] examined 72 patients and reported that vascular invasion at univariate together with multivariate analysis, was a significant prognostic factor in patients with resected, node-negative NSCLC whereas lymph vessel infiltration had no significant impact on outcome. In particular if it was present invasion of the blood vessels the survival rate was 23.5%, in cases without invasion 74.5% (p<or=0.01) [27] (Table 2). In contrast, Fujisawa and colleagues reported both blood (p=0.0046) and lymphatic vessel invasion (p=0.0267) as prognostic factors in 66 NSCLC [13].…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Factors in Early Stage Non-Small Cell Lung Cancer: The Importance of Number of Resected Lymph Nodes and Vascular Invasion

Santinelli¹

2013

Chemotherapy

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Background: Despite an appropriate surgical treatment, half of early-stage non-small cell lung cancer patients will die due to lung cancer. The number of resected lymph-nodes and vascular invasion has proved to be a prognostic factor in other solid tumors, as well as breast and colorectal cancer. Here we evaluate their prognostic impact in the largest mono-centric series of resected non-small cell lung cancer patients. Methods:Clinical and pathological characteristics and prognostic outcomes of four hundred thirty-nine consecutive patients undergoing radical surgical resection for non-small cell lung cancer at our Institution were evaluated. Results:The multivariate analysis showed that number of resected lymph nodes, vascular invasion and sex had a prognostic impact on overall survival. The optimal cut-off number of lymph nodes with the highest sensitivity and specificity for estimating the outcome was set at ten after Receiver Operating Characteristics curve analysis. Removing ten lymph nodes in our study represents a cut-off with a significant prognostic impact particularly in resected stage II non-small cell lung cancer. Conclusions:Similarly to other cancer types (for example colorectal cancer), our results suggest that an adequate classification of non-small cell lung cancer should always include an adequate lymph nodes clearance, particularly in stage II non-small cell lung cancer. Again vascular invasion resulted independent prognostic factors for overall survival. Therefore the number of resected lymph nodes, together with vascular invasion, may also drive the selection of nonsmall cell lung cancer patients for adjuvant treatment. Lung cancer is one of more aggressive tumor. Lung tumor surgery with loco-regional lymphadenectomy represents the only way for the eradication of neoplastic disease. In particular, an adequate lymph nodes clearance, especially in stage II non-small cell lung cancer may modify prognosis.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Prognostic Factors in Early Stage Non-Small Cell Lung Cancer: The Importance of Number of Resected Lymph Nodes and Vascular Invasion

Santinelli¹

2013

Chemotherapy

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“…patients, including stage I patients, who have undergone radical resection (Ichinose et al, 1994;Kessler et al, 1996;Duarte et al, 1998;Port et al, 2003;Gabor et al, 2004;Sakao et al, 2004); the frequency of radical resection generally ranges from 15 to 36% in the literature (Rigau et al, 2002;Funai et al, 2011). In our research, we retrospectively studied the follow-up records of stage I NSCLC patients to analyze the relationship between LVI and prognosis.…”

Section: Discussionmentioning

confidence: 98%

Clinical significance of lymphatic vessel invasion in stage I non-small cell lung cancer patients

Ma¹,

Chu²,

Liu³

2015

Genet. Mol. Res.

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ABSTRACT. The aim of this retrospective study was to evaluate the prognostic influence of lymphatic vessel invasion (LVI) in stage I non-small cell lung cancer (NSCLC) patients. From January 2004 to December 2007, LVI was detected in 57 patients with T1N0M0 NSCLC; therefore, 114 patients with the same pathology, T stage, and surgery method, but without LVI, were selected as the control group to compare survival. The overall survival and relapse-free survival rates were estimated using the Kaplan-Meier method, log-rank test, and Cox proportional hazards analysis. The average follow-up length was 59.94 ± 23.1 months. The 5-year overall survival rates of the LVI-negative and the LVI-positive groups were 90.54 and 70.1%, respectively (P = 0.002). A multivariate analysis revealed LVI to be an independent predictive factor (hazard ratio = 4.562; P = 0.004). The 5-year overall survival rates for patients who received postoperative adjunctive therapy and those who did not in the LVI-positive group were 88.2 and 61.5%, respectively, with a P value less than 0.05 in both univariate and multivariate analyses. LVI is a poor prognostic factor in stage I NSCLC patients; postoperative adjunctive therapy is needed to improve the 1820 K.F. Ma et al.

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“…[20][21][22][23] A number of studies [24][25][26] have evaluated the prognostic impact of large-vessel (arterial and/ or venous) invasion independent of lymphatic invasion with somewhat conflicting results. For this reason, it is permissible to report the presence of vascular and/or lymphatic invasion under the single heading of lymphovascular invasion.…”

Section: Microscopic Elementsmentioning

confidence: 99%

Data Set for Reporting of Lung Carcinomas: Recommendations From International Collaboration on Cancer Reporting

Jones

Churg²,

Henderson³

et al. 2013

Archives of Pathology & Laboratory Medicine

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Objective.-To develop an evidence-based reporting data set for each cancer site.Design.-A project to develop data sets for prostate, endometrium, and lung cancers and malignant melanoma was piloted by the quadripartite group.Results.-A set of required and recommended data elements and appropriate responses for each element were agreed upon for the reporting of lung cancer.Conclusions.-This review describes the process of development of the lung cancer data set.

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Invasion of blood vessels as significant prognostic factor in radically resected T1-3N0M0 non-small-cell lung cancer

Abstract: In resectable N0 patients with NSCLC the microscopic invasion of blood vessels should be considered as an additional prognostic parameter.

Cited by 79 publications

References 10 publications

Prognostic Factors in Early Stage Non-Small Cell Lung Cancer: The Importance of Number of Resected Lymph Nodes and Vascular Invasion

Prognostic Factors in Early Stage Non-Small Cell Lung Cancer: The Importance of Number of Resected Lymph Nodes and Vascular Invasion

Clinical significance of lymphatic vessel invasion in stage I non-small cell lung cancer patients

Data Set for Reporting of Lung Carcinomas: Recommendations From International Collaboration on Cancer Reporting

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