Invasion of Adjacent Lumbar Vertebral Body from Renal Pelvis Carcinoma: Associated With Bone Metastasis But Easily Overlooked on Initial CT Scan

Abstract

Background/Aim: We hypothesized that regional tumor growth into L1 and L2 vertebral bodies from renal pelvis carcinoma was linked to the development of bone metastases. Materials and Methods: Criteria for the study were: (i) Metastatic renal pelvis carcinoma confirmed via pathology and computed tomographic (CT) scan, (ii) L1 and L2 invasion confirmed from retrospective CT scan review, and (iii) detection of bone metastases using radionuclide images/CT scans. Results: A total of 71 cases were enrolled in the study. Initial L1 and L2 vertebral body invasion. were detected in 45 (63%) patients. As well as L1 and L2 invasion, 32 (71%) had development of bone metastases. All bone lesions were osteolytic. Initial L1 and L2 invasion (p<0.00001) was associated with the development of bone metastasis. Conclusion: CT scan can help to detect L1 and L2 vertebral body invasion in patients with renal pelvis carcinoma. Early identification and optimal management of such patients is necessary.

Development and Validation of a Predictive Model to Evaluate the Risk of Bone Metastasis in Kidney Cancer

“…As mentioned above for the metastatic mechanism, the renal vein and inferior vena cava are a critical part of distant metastasis. In patients developing pulmonary/cerebral/liver metastasis, tumor cells have escaped and the risk of BMs is inevitably significantly elevated ( 29 – 32 ). The KM curves presented in this study also confirmed that patients with BMs have a worse prognosis than patients without.…”

“…On the other hand, the surgical criteria for renal pelvic RCC require a greater extent of resection compared with kidney cancer, which is one of the explanations for effective patient protection ( 43 ). However, previous studies have reported the renal vein or inferior vena cava (IVC) involvement is associated with early onset of metastasis in renal pelvis RCC ( 29 ). There is a long way to go for exploring the mechanisms between the site of carcinoma origin and BMs.…”

Identification of Risk Factors for Bone Metastases in Patients With Renal Pelvis Cancer

“…Рост заболеваемости злокачественными новообразованиями и смертность от них регистрируется в большинстве стран мира [1,2,3]. Рак уротелия в структуре злокачественных новообразований занимает 4 место после рака простаты (или молочных желез), легкого и колоректального рака [4,8,11]. В странах Западной Европы каждый год на 100 0000 населения ди-агностируется 1-2 случая уротелиального рака верхних мочевых путей.…”

“…На момент выявления новообразования до 60% больных раком верхних мочевых путей имеют метастазы. Наиболее часто карцинома почечной лоханки метастазирует в лимфатические узлы, кости, легкие, печень, брюшину [4]. Новые разработки в области эндоскопического лечения, химиотерапии улучшили прогноз для пациентов с раком уротелия верхних мочевых путей, что подчеркивает актуальность точного и раннего выявления и определения стадии заболевания с помо- Ретроспективно были проанализированы КТ-исследования органов брюшной полости, забрюшинного пространства, грудной клетки и результаты остеосцинтиграфии пациентов с метастатическим раком почечной лоханки.…”