Invasion by Trichinella spiralis infective larvae affects the levels of inflammatory cytokines in intestinal epithelial cells in vitro

Ming, Liang; Peng, Ruo Yu; Zhang, Lei; Zhang, Chun Li; Lv, Pin; Wang, Zhong Quan; Cui, Jing; Ren, Hui

doi:10.1016/j.exppara.2016.10.003

Cited by 15 publications

(15 citation statements)

References 39 publications

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“…The T. spiralis ‐L1 antigens induce the maturation of DCs, which leads to the expression of the major histocompatibility complex class II (MHC II), promoting the development to a Th1 immune response . Several studies, both in vitro and in vivo, have shown that during the early stage of intestinal infection by T. spiralis there is a significant increase in Th1 cytokines such as IL‐12, INF‐γ, IL‐ 1β and TNF‐α . Due to the important role of these cytokines (Th1) in the host immune response against T. spiralis infection, in this study, the Th1 cytokine profile was first evaluated during the intestinal phase of T. spiralis infection, and we observed that serum levels of IL‐12, INF‐γ, IL‐1β and TNF‐α increased significantly.…”

Section: Discussionmentioning

confidence: 99%

Resiniferatoxin modulates the Th1 immune response and protects the host during intestinal nematode infection

Muñoz‐Carrillo

Contreras-Cordero

Muñoz-López

et al. 2017

Parasite Immunology

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In the early stage of the intestinal phase of Trichinella spiralis infection, the host triggers a Th1-type immune response with the aim of eliminating the parasite. However, this response damages the host which favours the survival of the parasite. In the search for novel pharmacological strategies that inhibit the Th1 immune response and assist the host against T. spiralis infection, a recent study showed that resiniferatoxin had anti-inflammatory activity contributed to the host in T. spiralis infection. In this study, we evaluated whether RTX modulates the host immune response through the inhibition of Th1 cytokines in the intestinal phase. In addition, it was determined whether the treatment with RTX affects the infectivity of T. spiralis-L1 and the development of the T. spiralis life cycle. Our results show that RTX decreased serum levels of IL-12, INF-γ, IL-1β, TNF-α and parasite burden on muscle tissue. It was observed that T. spiralis-L1 treated with RTX decreased their infectivity affecting the development of the T. spiralis life cycle in mouse. These results demonstrate that RTX is able to inhibit the production of Th1 cytokines, contributing to the defence against T. spiralis, which places it as a potential drug modulator of the immune response.

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Section: Discussionmentioning

confidence: 99%

Resiniferatoxin modulates the Th1 immune response and protects the host during intestinal nematode infection

Muñoz‐Carrillo

Contreras-Cordero

Muñoz-López

et al. 2017

Parasite Immunology

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“…PAMPs derived from helminth parasites induce the activation and maturation of dendritic cells [147,148], promoting the development of the Th1 immune response [149], which results in a significant increase of Th1 cytokines such as IL-12 [150][151][152], INF-γ [149][150][151][152][153], IL-1β [152,154], and TNF-α [150][151][152]155] (Figure 5). However, in recent years, several studies have shown that this immune response of Th1 type favors infection by helminth parasites.…”

Section: Immune System Activation By Parasitic Helminth Infectionmentioning

confidence: 99%

Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

Muñoz‐Carrillo¹,

Contreras-Cordero²,

Gutiérrez-Coronado³

et al. 2019

Immune Response Activation and Immunomodulation

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Pathogen infections are recognized by the immune system, which consists of two types of responses: an innate immune response that recognizes pathogenassociated molecular patterns (PAMPs) and an antigen-specific adaptive immune response. In both responses, there are several activated cells of the immune system, which play a key role in establishing the environment of cytokines, thus directing their differentiation either suppressing or promoting the immune response. This immune response is crucial against pathogen infections. In this chapter, we will describe the crucial role played by different families of cytokines during activation of the immune system to eliminate infectious pathogens.

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“…The Th1 type immune response against T. spiralis is characterized by a significant increase in Th1 cytokines such as IL-12 [67][68][69], INF-γ [48,[67][68][69][70], IL-1β [69,71] and TNF-α ( Figure 4) [ [67][68][69]72]. In recent years, studies have shown that the production of Th1 cytokines is directly associated with the development of the inflammatory response and intestinal pathology, which favors the infection by T. spiralis.…”

Section: Immune Response Against Trichinella Spiralismentioning

confidence: 99%

“…Finally, IL-1β is a proinflammatory cytokine [92,93], which is produced during infection by T. spiralis, participating in the inflammatory bowel response. However, until now, its function is not well known [69,71].…”

Section: Immune Response Against Trichinella Spiralismentioning

confidence: 99%

Current Aspects in Trichinellosis

Muñoz‐Carrillo¹,

Maldonado-Tapia²,

Luna³

et al. 2019

Parasites and Parasitic Diseases

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Currently, it is estimated that more than 11 million humans in the world are infected by helminth parasites of Trichinella species, mainly by Trichinella spiralis (T. spiralis), responsible for causing Trichinellosis disease in both animals and humans. Trichinellosis is a cosmopolitan parasitic zoonotic disease, which has direct relevance to human and animal health, because it presents a constant and important challenge to the host's immune system, especially through the intestinal tract. Currently, there is an intense investigation of new strategies in pharmacotherapy and immunotherapy against infection by Trichinella spiralis. In this chapter, we will present the most current aspects of biology, epidemiology, immunology, clinicopathology, pharmacotherapy and immunotherapy in Trichinellosis.

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Invasion by Trichinella spiralis infective larvae affects the levels of inflammatory cytokines in intestinal epithelial cells in vitro

Cited by 15 publications

References 39 publications

Resiniferatoxin modulates the Th1 immune response and protects the host during intestinal nematode infection

Resiniferatoxin modulates the Th1 immune response and protects the host during intestinal nematode infection

Cytokine Profiling Plays a Crucial Role in Activating Immune System to Clear Infectious Pathogens

Current Aspects in Trichinellosis

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