Invariant NKT cells increase lipopolysacchride-induced pregnancy loss by a mechanism involving Th1 and Th17 responses

Abstract

Our results suggest that iNKT cells may play a role in LPS-induced pregnancy loss by Th1 and Th17 cytokine-dependent manner.

Effect of the p53–tristetraprolin–stathmin-1 pathway on trophoblasts at maternal–fetal interface

“…Recurrent spontaneous abortion (RSA) is defined as the occurrence of two or more consecutive pregnancy losses before 24 weeks of gestation [2]. In recent years, many molecules (including eukaryotic translation initiation factor 5A [eIF5A] [3] and peroxiredoxin 2 [4]) and immune cells such as dendritic cells, natural killer (NK) cells [5, 6], invariant NK T (iNKT) cells [7,8], T helper (Th)1, and Th17 cells [9] have been linked with RSA.…”

CpG Oligodeoxynucleotides Downregulate Placental Adiponectin and Increase Embryo Loss in Non‐Obese Diabetic Mice

“…During pregnancy, bacterial infections may damage the local molecular and cellular microenvironment, and aberrant cellular interactions at the maternal–fetal interface can lead to serious complications of pregnancy, such as implantation failure, embryo loss, spontaneous abortion, premature delivery, pre‐eclampsia, and intrauterine growth restriction 3, 4, 5…”

“…2 During pregnancy, bacterial infections may damage the local molecular and cellular microenvironment, and aberrant cellular interactions at the maternal-fetal interface can lead to serious complications of pregnancy, such as implantation failure, embryo loss, spontaneous abortion, premature delivery, pre-eclampsia, and intrauterine growth restriction. [3][4][5] Toll-like receptor 9 (TLR9) recognizes unmethylated CpG dinucleotides, a characteristic feature of microbial DNA. CpG oligodeoxynucleotides (ODNs) are short single-stranded synthetic DNA molecules containing unmethylated CpG motifs that mimic microbial DNA and can therefore produce an immunostimulatory response.…”

IL‐17 Induces Fetal Loss in a CBA/J×BALB/c Mouse Model, and an Anti‐IL‐17 Antibody Prevents Fetal Loss in a CBA/J ×DBA/2 Mouse Model

“…Recombinant IL (rIL)‐17 significantly increased abortion rates in a CBA/J× BALB/c mouse model . IL‐17 was remarkably upregulated in mice treated with lipopolysaccharide (LPS) and a higher serum IL‐17 level corresponding to a higher early fetal loss . Previous studies convinced us that Th17 cells exert adverse effects on pregnancy.…”