2022
DOI: 10.1016/j.clinsp.2022.100032
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Invariant Natural Killer T-cells and their subtypes may play a role in the pathogenesis of endometriosis

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Cited by 6 publications
(7 citation statements)
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“…In addition to these studies which largely compare bulk CD8 T cell ratios, some papers report on CD8 expression within other subpopulations of T cells, such as iNKT ( 52 ) and MAIT ( 41 ), or subsets of the global CD8 T repertoire such as T CM and T EM subtypes ( 46 ). CD8 expression on iNKT cells in combination with the regulatory cytokines IL-6, IL-17 and IL-10 were unaltered between health and endometriosis controls ( 52 ). Although Li et al.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…In addition to these studies which largely compare bulk CD8 T cell ratios, some papers report on CD8 expression within other subpopulations of T cells, such as iNKT ( 52 ) and MAIT ( 41 ), or subsets of the global CD8 T repertoire such as T CM and T EM subtypes ( 46 ). CD8 expression on iNKT cells in combination with the regulatory cytokines IL-6, IL-17 and IL-10 were unaltered between health and endometriosis controls ( 52 ). Although Li et al.…”
Section: Resultsmentioning
confidence: 99%
“…In addition to these studies which largely compare bulk CD8 T cell ratios, some papers report on CD8 expression within other subpopulations of T cells, such as iNKT (52) and MAIT (41), or subsets of the global CD8 T repertoire such as T CM and T EM subtypes (46). CD8 expression on iNKT cells in combination with the regulatory cytokines IL-6, IL-17 and IL-10 were unaltered between health and endometriosis controls (52). Although Li et al did not identify differences in the overall CD8+ MAIT population between endometriosis patients and controls (the majority of MAIT cells are CD8+), they found an increased frequency of CD8+ cells among MAIT subtypes in the peripheral blood of patients as well as controls when compared to global CD8 T cells (p = 0.003 and p = 0.0002, respectively) (41).…”
Section: Cd8+ T Cells In Peripheral Bloodmentioning
confidence: 99%
“…Studies have shown a progressive decrease in M1 macrophages and a progressive increase in M2 macrophages from the early to advanced stages of endometriosis (Laganà et al, 2020). Invariant natural killer T cells (iNKT) may also be involved in the pathogenesis of endometriosis (Correa et al, 2022).…”
Section: Biomarkers For Fundamental Mechanisms Of Endometriosismentioning
confidence: 99%
“…Endometriosis is regarded as hormone-dependent as several studies have reported that the endometrium is modulated by steroid hormones, mainly including estrogen and progesterone, which regulate the expression of various genes at diverse stages of the menstrual cycle. 140 The level of estrogen detected in the ectopic endometrium of endometriotic women is elevated compared to that in the eutopic endometrium or normal endometrium, which depends on local estrogen metabolism rather than circulating levels. 141 Ectopic endometrial tissues can synthesize abundant E2 de novo from cholesterol, resulting from the high expression of aromatase (the key enzyme for estrogen biosynthesis) and steroidogenic acute regulatory protein (StAR), while normal endometrial tissues cannot synthesize estrogen due to the lack of these enzymes.…”
Section: Molecular Mechanisms Of Resveratrol Against Endometriosismentioning
confidence: 99%