Invariant Natural Killer T-cells and their subtypes may play a role in the pathogenesis of endometriosis

Correa, Frederico J S; Andres, Marina Paula; Rocha, Tainá Pezzin; Carvalho, Ana Eduarda Zulim de; Aloia, Thiago Pinheiro Arrais; Corpa, Marcus; Kallas, Esper G.; Mangueira, Cristóvão Luis Pitangueiras; Baracat, Edmund C.; Carvalho, Karina I.; Abrão, Maurício Simões

doi:10.1016/j.clinsp.2022.100032

Cited by 6 publications

(7 citation statements)

References 38 publications

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Section: Resultsmentioning

confidence: 99%

“…In addition to these studies which largely compare bulk CD8 T cell ratios, some papers report on CD8 expression within other subpopulations of T cells, such as iNKT (52) and MAIT (41), or subsets of the global CD8 T repertoire such as T CM and T EM subtypes (46). CD8 expression on iNKT cells in combination with the regulatory cytokines IL-6, IL-17 and IL-10 were unaltered between health and endometriosis controls (52). Although Li et al did not identify differences in the overall CD8+ MAIT population between endometriosis patients and controls (the majority of MAIT cells are CD8+), they found an increased frequency of CD8+ cells among MAIT subtypes in the peripheral blood of patients as well as controls when compared to global CD8 T cells (p = 0.003 and p = 0.0002, respectively) (41).…”

Section: Cd8+ T Cells In Peripheral Bloodmentioning

confidence: 99%

See 1 more Smart Citation

The role of CD8+ T cells in endometriosis: a systematic review

Kisovar¹,

Becker²,

Granne³

et al. 2023

Front. Immunol.

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BackgroundEndometriosis is a chronic disease affecting 6–10% of women of reproductive age. It is an important cause of infertility and chronic pelvic pain with poorly understood aetiology. CD8+ T (CD8 T) cells were shown to be linked to infertility and chronic pain and play a significant role in lesion clearance in other pathologies, yet their function in endometriosis is unknown. We systematically evaluated the literature on the CD8 T in peripheral blood and endometriosis-associated tissues to determine the current understanding of their pathophysiological and clinical relevance in the disease and associated conditions (e.g. infertility and pelvic pain).MethodsFour databases were searched (MEDLINE, EMBASE, Web of Science, CINAHL), from database inception until September 2022, for papers written in the English language with database-specific relevant terms/free-text terms from two categories: CD8 T cells and endometriosis. We included peer-reviewed papers investigating CD8 T cells in peripheral blood and endometriosis-associated tissues of patients with surgically confirmed endometriosis between menarche and menopause, and animal models with oestrous cycles. Studies enrolling participants with other gynaecological pathologies (except uterine fibroids and tubal factor infertility used as controls), cancer, immune diseases, or taking immune or hormonal therapy were excluded.Results28 published case-control studies and gene set analyses investigating CD8 T cells in endometriosis were included. Data consistently indicate that CD8 T cells are enriched in endometriotic lesions in comparison to eutopic endometrium, with no differences in peripheral blood CD8 T populations between patients and healthy controls. Evidence on CD8 T cells in peritoneal fluid and eutopic endometrium is conflicting. CD8 T cell cytotoxicity was increased in the menstrual effluent of patients, and genomic analyses have shown a clear trend of enriched CD8 T effector memory cells in the eutopic endometrium of patients.ConclusionLiterature on CD8 T cells in endometriosis-associated tissues is inconsistent. Increased CD8 T levels are found in endometriotic lesions, however, their activation potential is understudied in all relevant tissues. Future research should focus on identifying clinically relevant phenotypes to support the development of non-invasive diagnostic and treatment strategies.Systematic Review RegistrationPROSPERO identifier CRD42021233304

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Section: Resultsmentioning

confidence: 99%

Section: Cd8+ T Cells In Peripheral Bloodmentioning

confidence: 99%

The role of CD8+ T cells in endometriosis: a systematic review

Kisovar¹,

Becker²,

Granne³

et al. 2023

Front. Immunol.

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“…Studies have shown a progressive decrease in M1 macrophages and a progressive increase in M2 macrophages from the early to advanced stages of endometriosis (Laganà et al, 2020). Invariant natural killer T cells (iNKT) may also be involved in the pathogenesis of endometriosis (Correa et al, 2022).…”

Section: Biomarkers For Fundamental Mechanisms Of Endometriosismentioning

confidence: 99%

Untitled

2024

Facts Views Vis ObGyn

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Endometriosis is a complex and chronic gynaecological disorder that affects millions of women worldwide, leading to significant morbidity and impacting reproductive health. This condition affects up to 10% of women of reproductive age and is characterised by the presence of endometrial-like tissue outside the uterus, potentially leading to symptoms such as chronic pelvic pain, dysmenorrhoea, dyspareunia, and infertility. The Montreux summit brought a number of experts in this field together to provide a platform for discussion and exchange of ideas. These proceedings summarise the six main topics that were discussed at this summit to shed light on future directions of endometriosis classification, diagnosis, and therapeutical management. The first question addressed the possibility of preventing endometriosis in the future by identifying risk factors, genetic predispositions, and further understanding of the pathophysiology of the condition to develop targeted interventions. The clinical presentation of endometriosis is varied, and the correlation between symptoms severity and disease extent is unclear. While there is currently no universally accepted optimal classification system for endometriosis, several attempts striving towards its optimisation -each with its own advantages and limitations -were discussed. The ideal classification should be able to reconcile disease status based on the various diagnostic tools, and prognosis to guide proper patient tailored management. Regarding diagnosis, we focused on future tools and critically discussed emerging approaches aimed at reducing diagnostic delay. Preserving fertility in endometriosis patients was another debatable aspect of management that was reviewed. Moreover, besides current treatment modalities, potential novel medical therapies that can target underlying mechanisms, provide effective symptom relief, and minimise side effects in endometriotic patients were considered, including hormonal therapies, immunomodulation, and regenerative medicine. Finally, the question of hormonal substitution therapy after radical treatment for endometriosis was debated, weighing the benefits of hormone replacement.

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“…Endometriosis is regarded as hormone-dependent as several studies have reported that the endometrium is modulated by steroid hormones, mainly including estrogen and progesterone, which regulate the expression of various genes at diverse stages of the menstrual cycle. 140 The level of estrogen detected in the ectopic endometrium of endometriotic women is elevated compared to that in the eutopic endometrium or normal endometrium, which depends on local estrogen metabolism rather than circulating levels. 141 Ectopic endometrial tissues can synthesize abundant E2 de novo from cholesterol, resulting from the high expression of aromatase (the key enzyme for estrogen biosynthesis) and steroidogenic acute regulatory protein (StAR), while normal endometrial tissues cannot synthesize estrogen due to the lack of these enzymes.…”

Section: Molecular Mechanisms Of Resveratrol Against Endometriosismentioning

confidence: 99%

Review of the Potential Therapeutic Effects and Molecular Mechanisms of Resveratrol on Endometriosis

Jiang¹,

Chen²,

Gu³

et al. 2023

IJWH

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Endometriosis is a hormone-dependent inflammatory disease characterized by the existence of endometrial tissues outside the uterine cavity. Pharmacotherapy and surgery are the current dominant management options for endometriosis. The greater incidence of recurrence and reoperation after surgical treatment as well as the adverse effects of medical approaches predispose patients to potential limitations for their long-term usage. Consequently, it is essential to explore novel supplementary and alternative drugs to ameliorate the therapeutic outcomes of endometriotic patients. Resveratrol is a phenolic compound that has attracted increasing interest from many researchers due to its pleiotropic biological activities. Here, we review the possible therapeutic efficacies and molecular mechanisms of resveratrol against endometriosis based on in vitro, animal, and clinical studies. The potential mechanisms of resveratrol include anti-proliferative, pro-apoptotic, anti-angiogenic, anti-oxidative stress, anti-invasive and anti-adhesive effects, thereby suggesting that resveratrol is a promising candidate for endometriosis. Because most studies have investigated the effectiveness of resveratrol on endometriosis via in vitro trials and/or experimental animal models, further high-quality clinical trials should be undertaken to comprehensively estimate the clinical application feasibility of resveratrol on endometriosis.

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Invariant Natural Killer T-cells and their subtypes may play a role in the pathogenesis of endometriosis

Cited by 6 publications

References 38 publications

The role of CD8+ T cells in endometriosis: a systematic review

The role of CD8+ T cells in endometriosis: a systematic review

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Review of the Potential Therapeutic Effects and Molecular Mechanisms of Resveratrol on Endometriosis

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