Inv(4)(p14q27) in a Case with de novo Acute Nonlymphocytic Leukemia

Benasayag, S.; Arias, Eugenia; Baialardo, Edgardo; Reyes, Myriam; Sapia, Sandra; Bistmans, Alicia; Slavutsky, Irma

doi:10.1159/000063058

Acta Haematol

2002

DOI: 10.1159/000063058

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Inv(4)(p14q27) in a Case with de novo Acute Nonlymphocytic Leukemia

S. Benasayag

Eugenia Arias²,

Edgardo Baialardo³

et al.

Abstract: An inversion, inv(4)(p14q27), was found as the sole karyotypic anomaly at diagnosis in the bone marrow cells from a 65-year-old male patient with an M4 acute nonlymphocytic leukemia (ANLL). To our knowledge, the breakpoints observed in this case appear to be different from other inversions of chromosome 4 previously described in ANLL. The patient we described had a poor response to chemotherapy and had a short survival.

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Cited by 2 publications

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“…An inv(4)(p14q27) was described as the sole karyotypic anomaly at diagnosis in the bone marrow from an adult patient who responded poorly to chemotherapy and had a short survival time (Benasayag et al, 2002).…”

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Atypical chromosome abnormalities in acute myeloid leukemia type M4

Fett‐Conte

Estrela²,

Vendrame-Goloni

et al. 2007

Genet. Mol. Biol.

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This study reports an adult AML-M4 patient with atypical chromosomal aberrations present in all dividing bone marrow cell at diagnosis: t(1;8)(p32.1;q24.2), der(9)t(9;10)(q22;?), and ins(19;9)(p13.3;q22q34) that may have originated transcripts with leukemogenic potential. Acute non-lymphocytic or myelogenous leukemia (ANLL or AML) represents a hematopoietic malignancy characterized by abnormal cell proliferation and stalled differentiation leading to the accumulation of immature cells in the marrow itself, in peripheral blood and eventually in other tissues. Primary chromosomal abnormalities in AML are highly specific and considered to be associated with leukemic transformation, whereas secondary changes are less specific and probably contribute to disease progression. As reviewed by Chen and Sandberg. (2002), the common chromosomal abnormalities in the acute myelomonocytic leukemia FAB (French-American-British Cooperative Group) type M4 include monosomy 5 or del(5q), monosomy 7 or del(7q), trisomy 8, t(6;9) (p23;q34), and rearrangements involving the Mixed Lineage Leukemia (MLL) gene mapped at 11q23 [del(11) (q23); t(9;11)(p22;q23), t(11;19)(q23;p13)], and Core Binding Factor B (CBFβ) mapped at 16q22 [del(16)(q22), inv(16)(p13q22), t(16;16)(p13;q22)]. Less frequently, trisomy 4, trisomy 22, t(8;21)(q22;q22) and rearrangements with breakpoints in 3q21, 3q26, 8p11, 11p15 and 11q13 have also been reported in FAB M4 type patients

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mentioning

confidence: 99%

Atypical chromosome abnormalities in acute myeloid leukemia type M4

Fett‐Conte

Estrela²,

Vendrame-Goloni

et al. 2007

Genet. Mol. Biol.

View full text Add to dashboard Cite

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inv (4)(p13q13) in patient with essential thrombocythemia: A case report

Aydın

Salim

Yücel

et al. 2015

Hematology/Oncology and Stem Cell Therapy

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The inv (4)(p13q13) cytogenetic abnormality is uncommon in hematologic malignancies. So far, it has not been previously reported in patients with essential thrombocythemia (ET). We report a first case of ET with inv (4)(p13q13) karyotype in a 69-year-old female patient who developed myelofibrosis at follow up. Conventional cytogenetic analysis from a bone marrow sample showed 46, XX, inv (4)(p13q13) [3]/46, XX [4] at diagnosis and subsequent analysis revealed the same abnormal karyotype during the myelofibrosis phase (46, XX, inv (4)(p13q13) [13]/46, XX [26]). The prognostic significance of this chromosomal abnormality is unknown.

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Inv(4)(p14q27) in a Case with de novo Acute Nonlymphocytic Leukemia

Cited by 2 publications

References 17 publications

Atypical chromosome abnormalities in acute myeloid leukemia type M4

Atypical chromosome abnormalities in acute myeloid leukemia type M4

inv (4)(p13q13) in patient with essential thrombocythemia: A case report

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